Signal Transduction
The Signal Transduction Program explores the molecular signals within and between cells that drive cancer. These researchers are developing innovative new models for human tumors and advanced imaging technology with a goal of identifying potential “druggable” targets and mechanisms of drug resistance in cancer. Current research is focused on identifying and targeting the signaling mechanisms and tumor-host interactions that drive cancer.
Program Co-leaders
The Signal Transduction Program has two major overarching themes: 1) Identifying and targeting signaling in cancer; and 2) Characterizing and attacking tumor-host interactions driving cancer. In addition, the Signal Transduction Program is working to develop improved models of cancer. Program members include experts who bring an in-depth understanding of different families of signaling proteins, integrated with investigators who have expertise in cutting-edge technologies and systems. As such, the program generates basic discoveries that can drive the development of new cancer therapies.
Extensive collaborations among Signal Transduction Program members and other CSHL Cancer Center Programs have combined novel model systems of cancer, RNA interference, CRISPR, and state-of-the-art molecular/cellular and biochemical/proteomics approaches. Most Signal Transduction Program members also have clinical collaborators, predominately with investigators at Northwell Health. This highly collaborative and innovative environment has led to breakthroughs in our understanding of the signaling networks and immune interactions that drive cancer.
Turning off the immune system is hard. Turning it on against cancer is easier.
January 10, 2018
How Professor Doug Fearon’s experiences with autoimmune disease patients contributed to the discovery of a new potential immunotherapy for cancer.
Three Strohm Sisters Family Foundation donates $5,000 for research on lung cancer recurrence
January 8, 2018
A representative of the Three Strohm Sisters Family Foundation gave $5,000 for lung cancer recurrence research in Mikala Egeblad's lab.
One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells
October 19, 2017
Associate Professor Mikala Egeblad discovers that neutrophil extracellular traps (NETs) help cancer by creating holes in the tissue.
Halfway around the world, a reunion of friends opens door to a cancer discovery
August 31, 2017
After interviewing for a position in a pancreatic cancer lab at Cold Spring Harbor Laboratory, 7,000 miles from his hometown in South Korea, Chang-il.
Long-sought mechanism of metastasis is discovered in pancreatic cancer
July 27, 2017
An epigenetic factor reprograms gene enhancers, enabling cancer cells to “remember” an earlier developmental state and causing metastasis.
Newly discovered mutations impair key cell pathways in pancreatic cancer
May 8, 2017
Researchers have found important new clues to the development of pancreatic cancer.
Pershing Square Sohn cancer research prize awarded to CSHL’s Dr. Mikala Egeblad
May 8, 2017
Cold Spring Harbor Laboratory (CSHL) Associate Professor Mikala Egeblad, Ph.D., has been awarded the Pershing Square Sohn Prize.
Alexa DeAngelis didn’t see a place for herself in science, so she’s making one
April 28, 2017
For Alexa DeAngelis, who was recently awarded a Fulbright scholarship, combining a desire to help people with a passion for biochemistry means design.
New research explains why even targeted therapies eventually fail in lung cancer
March 29, 2017
Dr. Sordella and her team propose a novel theory of how some cancers circumvent the killing power of targeted therapies.
Discovery of distinct cell subtypes around tumors helps explain why pancreatic cancer is so hard to treat
February 23, 2017
Researchers finds that stroma,“wound”-like tissue that surrounds the tumors, helps explain why pancreatic cancer is so resistant to treatment.
Researchers identify “Achilles’ heel” of PTEN that helps drive prostate cancer progression
February 13, 2017
Researchers at CSHL have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it.
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
December 9, 2016
Truncated p53 proteins, presumed unimportant, now point to new drug targets for some of "the hardest cancers"
When antioxidants are pro-cancer
November 15, 2016
For Pancreatic Cancer Awareness Month, Base Pairs looks at the science of antioxidants and cancer.
No (real) moustache required to join the “Movember” party
November 15, 2016
Members of Trotman don fake moustaches in order to raise money for prostate cancer research during Movember.
Pancreas and colon tumors reprogram the liver, causing wasting and short-circuiting body’s immune response
November 8, 2016
Research reveals a mechanism that causes wasting in cancer and tests a way to reverse it.
Our most common infection-fighting white blood cells can be hijacked to support cancer spread
October 19, 2016
Neutrophils, the most common type of white blood cell, can be taken over by cancer cells and used as an aid in metastasis.
What’s the connection between antioxidants and cancer?
October 14, 2016
David Tuveson discusses the relationship between antioxidants and cancer, and how the former doesn't necessarily prevent the latter.
Novel drug therapy kills pancreatic cancer cells by reducing levels of antioxidants
July 28, 2016
Researchers demonstrate that in the specific context of pancreatic cells leading to cancer, raisin antioxidant levels should not be raised.
Discovery of new ovarian cancer signaling hub points to target for limiting metastasis
July 10, 2016
A team of researchers at Cold Spring Harbor Laboratory discovers new insights into signaling events that underlie metastasis in ovarian cancer cells.
How healthy cells might help cancer survive
February 4, 2016
A story on Mikala Egeblad's breast cancer research and the importance of the tumor microenvironment.
Masthead Cove Yacht Club raises over $7000 for CSHL cancer research at annual race
November 25, 2015
Members of the Masthead Cove Yacht Club (MCYC) raised $7,124 from their annual Masthead Race.
Joni Gladowsky Breast Cancer Foundation donates $80,000 to Cold Spring Harbor Laboratory
July 24, 2015
These proceeds will support breast cancer research in the laboratory of CSHL Professor Nicholas Tonks.
An immune system marker for therapy-resistant prostate cancer
June 4, 2015
Research shows how signaling by an immune system component appears to play an important role in driving particularly aggressive prostate cancer
Tumor surroundings are shown to affect progression of different cancer subtypes
May 27, 2015
Researchers discover that cancer progress differently based on characteristics of the tumor microenvironment.
Scientists show the mammary gland ‘remembers’ prior pregnancy, spurring milk production
May 7, 2015
Anecdotal reports of nursing mothers have long suggested that giving milk is a lot easier in second and subsequent pregnancies.
New signaling pathway discovered in HER2-positive breast cancer, and two potentially powerful drug targets
April 20, 2015
Rsearchers discovered a new pathway, which contains at least two potentially powerful drug targets
Study revises standard theory of how PTEN, a critical tumor suppressor, shuts off growth signals
April 9, 2015
Scientists discover new evidence explaining precisely how the protein encoded by PTEN (called PTEN) works
One experiment: Cellular highways carry anti-cancer cargoes
April 9, 2015
The gene called PTEN is one of the most important of the body’s natural tumor suppressors.
3D culture system for pancreatic cancer has potential to change therapeutic approaches
January 15, 2015
Organoid technology with human tissue provides a model for full progression of the disease
A novel biomarker for mutant p53 could help pathologists assessing tumors during surgery
January 5, 2015
New discovery may make it easy for cancer surgeons to determine if a patient has a potentially lethal mutation.
Building publication list.
Semir Beyaz
Are you really what you eat? Our goal is to uncover the precise mechanisms that link nutrition to organismal health and disease states at the cellular and molecular level. A particular focus in our lab is to understand how dietary perturbations affect the immune system and contribute to the risk of diseases that are associated with immune dysfunction such as cancer.
Mikala Egeblad
Cancer cells are surrounded by immune cells, blood vessels, chemical signals and a support matrix—collectively, the tumor microenvironment. Most microenvironments help tumors grow and metastasize, but some can restrict tumors. My lab studies how to target the bad microenvironments and support the good ones to combat cancer.
Douglas Fearon
I’m studying how to harness the power of the immune system to fight cancer. Our underlying premise is that the microenvironment within a tumor suppresses the immune system. We have found a way to eliminate this suppression in the mouse model of pancreatic cancer, which has led to development of a drug for human pancreatic cancer that will enter phase 1 clinical trials in 2015.
Tobias Janowitz
Cancer is a systemic disease. Using both laboratory and clinical research, my group investigates the connections between metabolism, endocrinology, and immunology to discover how the body’s response to a tumor can be used to improve treatment for patients with cancer.
Robert Maki
With joint appointments at CSHL and Northwell Health, I am working to expand clinical cancer research at our institutions to provide new treatments for patients as well as greater insight into the biology of this complex set of diseases. In my own research, I am collaborating on research in soft-tissue and bone sarcomas to better understand the cancer microenvironment and epigenetics, targeting molecular weaknesses to halt cancer growth.
Darryl Pappin
Our genome can encode hundreds of thousands of different proteins, the molecular machines that do the work that is the basis of life. I use proteomics, a combination of protein chemistry, mass spectrometry and informatics, to identify precisely which proteins are present in cells - cells from different tissues, developmental stages, and disease states.
Ullas Pedmale
Unlike animals, plants neither have specific organs that see or hear various stimuli, yet, plants are sensitive to their surrounding environment and modify their development according to various external signals. My lab studies how the environment of a plant modulates its growth and development. Understanding environmental control of growth will have far-reaching implications for agriculture, energy production, and many other human activities.
Raffaella Sordella
Two challenges in cancer biology guide my work: first, how do tumors become addicted to certain gene products, and second, how do tumors develop resistance to anti-cancer drugs. I focus on the epidermal growth factor receptor (EGFR), which is both addictive when mutated and a common source of drug resistance. We are also identifying new targets for the treatment of lung cancer.
Nicholas Tonks
Cells must constantly react to what is happening around them, adapting to changes in neighboring cells or the environment. I study the signals that cells use to exchange information with their surroundings. Our group is finding drugs that target these signals and thus can treat diabetes, obesity, cancer, and autism spectrum disorders.
Lloyd Trotman
We have recently developed the first genetic mouse model for therapy and analysis of metastatic prostate cancer. Now we can test if and how modern concepts of cancer evolution can outperform the 80-year-old standard of care - hormone deprivation therapy - and turn lethal prostate cancer into a curable disease.
David Tuveson
Pancreatic cancer is an extremely lethal malignancy. On average, patients who are diagnosed with pancreatic cancer succumb to the disease within 6 months. Research is the only way to defeat pancreatic cancer. My lab is making progress toward finding a cure by detecting the disease earlier and designing novel therapeutic approaches.
Linda Van Aelst
Normal cell function relies on coordinated communication between all the different parts of the cell. These communication signals control what a cell does, what shape it takes, and how it interacts with other cells. I study these signaling networks to understand how they guard against cancer and neurological disorders.
Johannes Yeh
Studies the creation of engineered biologics such as antibodies, proteins and peptides, for therapeutics and translational medicine. The lab employs protein engineering and chemical biology approaches to develop therapeutic biologics acting on cell signaling machineries in order to abrogate pathological cellular behavior. He is currently the Director of CSHL Cancer Center Antibody Shared Resource- a collaborative resource for high quality antibody development.