Johannes Yeh
Research Assistant Professor & Director, CSHL Antibody and Phage Display Shared Resource
Cancer Center Member
Ph.D., Cambridge University, 2006
jyeh@cshl.edu | 516-367-8812
Cells orchestrate proteins to conduct cell-cell communications and environment sensing in order to execute physiological functions. My lab investigates the mechanisms by which dysregulated signals cause diseases such as cancer, and we are developing therapeutics based on these mechanisms.
Cell signaling plays a central role in executing physiological functions such as cell growth, proliferation and differentiation. Dysregulated cell signaling cause diseases like cancers, diabetes or neurodegeneration. The Yeh lab studies the function of proteins involved in cell signaling and their roles in pathophysiology with the goal of developing therapeutics to abrogate pathological cellular behavior. To this end, we employ biomolecular engineering approaches to dissect signal transduction pathways and to target protein functions. These approaches have led to the development of several therapeutic inhibitors to target oncogenic receptors, transcription factors and extracellular matrix proteins. Most recently, the Yeh lab has been focused on developing therapeutic biologics to modulate the interplay between cancer cells and tumor microenvironment.
All Publications
Detection of incipient pancreatic cancer with novel tumor-specific antibodies in mouse models
10 Sep 2020 | bioRxiv
Oni, Tobiloba, Bautista, Carmelita, Merrill, Joseph, Goos, Jeroen, Rivera, Keith, Miyabayashi, Koji, Biffi, Giulia, Garcia, Libia, Plenker, Dennis, Patel, Hardik, Elyada, Ela, Samaritano, Maria, Yu, Kenneth, Pappin, Darryl, Goggins, Michael, Hruban, Ralph, Lewis, Jason, Lyons, Scott, Yeh, Johannes, Tuveson, David
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
28 Sep 2018 | Science | 361(6409)
Albrengues, J, Shields, M, Ng, D, Park, C, Ambrico, A, Poindexter, M, Upadhyay, P, Uyeminami, D, Pommier, A, Kuttner, V, Bruzas, E, Maiorino, L, Bautista, C, Carmona, E, Gimotty, P, Fearon, D, Chang, K, Lyons, S, Pinkerton, K, Trotman, L, Goldberg, M, Yeh, J, Egeblad, M
Amino-Acid-Catalyzed Direct Aldol Bioconjugation
20 Aug 2018 | Organic Letters
Howard, T, Cohen, R, Nwajiobi, O, Muneeswaran, Z, Sim, Y, Lahankar, N, Yeh, J, Raj, M
eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells.
8 Feb 2017 | Scientific Reports | 7:41619
Yeh, Johannes, Nam, Kwangho, Yeh, Joshua, Perrimon, Norbert
Towards understanding cell penetration by stapled peptides
2015 | MedChemComm | 6(1):111-119
Chu, Qian, Moellering, Raymond, Hilinski, Gerard, Kim, Young-Woo, Grossmann, Tom, Yeh, Johannes, Verdine, Gregory
Protein-templated peptide ligation.
22 Apr 2014 | Angewandte Chemie International Edition | 53(17):4337-4340
Brauckhoff, Nicolas, Hahne, Gernot, Yeh, Johannes, Grossmann, Tom
PAPTi: a peptide aptamer interference toolkit for perturbation of protein-protein interaction networks.
2013 | Scientific Reports | 3:1156
Yeh, Johannes, Binari, Richard, Gocha, Tenzin, Dasgupta, Ramanuj, Perrimon, Norbert
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.
30 Oct 2012 | Proceedings of the National Academy of Sciences of USA | 109(44):17942-17947
Grossmann, Tom, Yeh, Johannes, Bowman, Brian, Chu, Qian, Moellering, Raymond, Verdine, Gregory
Design and validation of a neutral protein scaffold for the presentation of peptide aptamers.
7 Oct 2005 | Journal of Molecular Biology | 352(5):1118-1133
Woodman, Robbie, Yeh, Johannes, Laurenson, Sophie, Ko Ferrigno, Paul