Pancreatic cancer is an extremely lethal malignancy. On average, patients who are diagnosed with pancreatic cancer succumb to the disease within 6 months. Research is the only way to defeat pancreatic cancer. My lab is making progress toward finding a cure by detecting the disease earlier and designing novel therapeutic approaches.
David Tuveson’s laboratory uses murine and human models of pancreatic cancer to explore the fundamental biology of malignancy and thereby identify new diagnostic and treatment strategies. The lab’s approaches run the gamut from designing new model systems of disease to developing new therapeutic and diagnostic approaches for rapid evaluation in preclinical and clinical settings. The lab’s studies make use of organoid cultures—three-dimensional cultures of normal or cancerous epithelia—as ex vivo models to probe cancer biology. Current projects in the lab explore changes in redox metabolism associated with pancreatic cancer tumorigenesis, dissect signaling by the Ras oncogene, discover new biomarkers of early pancreas cancer, and identify mechanisms of cross-talk between pancreatic cancer cells and the tumor stroma. Novel treatment approaches suggested by these studies are then tested by performing therapeutic experiments in mouse models. To dissect molecular changes associated with pancreatic tumorigenesis, the Tuveson lab has generated a large collection of human patient-derived organoid models. By measuring the therapeutic sensitivities of patient-derived organoids, the lab is working to identify novel strategies to treat patients as well as markers of therapeutic response. The Tuveson Laboratory maintains strong links to clinical research, and the ultimate goal is confirmation of preclinical findings in early-phase trials. Collectively, the lab’s bench-to-bedside approach is codified as the “Cancer Therapeutics Initiative,” and this initiative will provide these same approaches to the entire CSHL cancer community.
Dr. Tuveson serves as Director of the Cold Spring Harbor Laboratory Cancer Center and the Chief Scientist for the Lustgarten Foundation.
Live @ the Lab with David Tuveson: Studying pancreatic cancer
July 29, 2020
Cold Spring Harbor Laboratory Cancer Center Director Dave Tuveson presents an exciting new model for studying pancreatic cancer.
Cancer researchers discuss COVID-19’s effect on the field
July 27, 2020
Dr. David Tuveson and Dr. Tobias Janowitz discuss in Cancer Discovery how the COVID-19 pandemic has changed cancer research.
The first mouse model of human pancreas cancer subtypes
July 23, 2020
CSHL researchers discovered how slow-growing pancreatic tumors can switch into a more deadly sub-type.
Blocking cholesterol storage could stop growth of pancreatic tumors
July 7, 2020
Interfering with the way pancreatic cancer cells process and store cholesterol can stop a tumor from growing.
Applying symptom tracking to COVID-19 outpatient care using famotidine
June 4, 2020
Researchers from CSHL and Northwell Health are developing a way to test promising COVID-19 drugs, like famotidine, by tracking outpatient symptoms.
Tuveson and Wigler elected AACR Academy Fellows
May 12, 2020
CSHL Cancer Center Director David Tuveson and Professor Michael Wigler were chosen as 2020 Fellows of the AACR Academy.
David Tuveson named President-Elect of AACR
April 21, 2020
CSHL Cancer Center Director David Tuveson has been elected President-Elect of the American Association for Cancer Research.
CSHL Cancer Center joins the AACI
January 10, 2020
The CSHL Cancer Center becomes the 100th member of the Association of American Cancer Institutes.
CSHL investigators rank among world’s most highly cited
December 11, 2019
Seven researchers affiliated with CSHL are among the scientists producing the top 1 percent of the most highly-cited research in the world.
CSHL wins TD Ready Challenge grant for organoid facility
December 3, 2019
CSHL is one of the recipients of the TD Ready Challenge grant to help support the upcoming organoid facility.