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Neuroscience

neuroscience qBrain mappingCSHL neuroscientists focus on understanding how neural connections in the brain translate into behavior. Their research provides insights into the circuitry underlying complex cognitive processes such as decision-making and attention, as well as developing tools to map circuit disruptions associated with neurological disorders, like Alzheimer’s disease, autism, schizophrenia and depression.

Neuroscience research at CSHL is centered on three broad themes: sensory processing, cognition, and mental disorders. Sensory processing research explores how sensory experiences, like sound, smell, and sight, are integrated with decision-making. The cognition group uses the tools of modern neuroscience (genetic, molecular, physiology and imaging) to study the neural circuitry that underlies attention, memory, and decision-making. Researchers also study cognitive disorders, defining the genetic basis of diseases like autism and schizophrenia and identifying the neural circuits that are disrupted in these disorders. In addition, there is an effort to develop new anatomical methods to improve our understanding of brain circuits, connectivity, and function.

Much of the work is highly collaborative and interdisciplinary. Many neuroscientists apply physics, math, and engineering principles to the study of cognition, including research funded by the Swartz Foundation.

Dinu Florin Albeanu

Dinu Florin Albeanu

How does the brain encode stimuli from the outside world to give rise to perceptions? What does a smell look like in the brain? The focus of my group is to understand how neural circuits compute sensory-motor transformations across different contexts, senses, and brain states to generate meaningful behaviors.

Arkarup Banerjee

Arkarup Banerjee

During a conversation, our brain must interpret what we hear and control our vocal response. How does the brain transform these auditory sensations into action? My laboratory uses singing mice as a model system to investigate the neural circuits in the brain that underlie vocal communication in mammals.

Jeremy C. Borniger

Jeremy C. Borniger

Patients with cancer frequently experience debilitating symptoms that can impair quality of life and reduce odds of survival. These include drastic changes in appetite, sleep/wake cycles, cognitive function, and pain, among others. Our lab aims to uncover mechanistic interactions between the brain and cancer that drive these phenomena. Reciprocally, we investigate how manipulation of specific brain circuits influences cancer processes in the body.

Lucas Cheadle

Lucas Cheadle

The trillions of connections between brain cells enable complex thought and behavior. These connections are wired with great precision through both genetics and in response to an organism’s experiences. Our lab seeks to understand how experiences engage specialized immune cells called microglia to shape the connectivity and function of the brain. We are further interested in how impairments in these processes can contribute to neurodevelopmental disorders such as autism.

Tatiana Engel

Tatiana Engel

My lab investigates how perception and cognition arise from changes in neural activity. We develop and apply computational methods to discover dynamic patterns in large-scale neural activity recordings. We then create mathematical models to explain how these activity changes emerge from signaling between neurons, ultimately driving behavior.

Hiro Furukawa

Hiro Furukawa

The nervous system transmits information by passing chemical signals from one nerve cell to the others. This signal transmission relies on a variety of proteins to receive and transmit the chemical signals. My group studies the structure and function of neurotransmitter receptors and ion channels that regulate fundamental neuronal activities.

Helen Hou

Helen Hou

The brain-body interaction is a two-sided coin: The brain can control movement of the body to fulfill behaviors, and behavior itself can affect brain function. We study how the brain orchestrates motor and physiological control in natural and innate behaviors, focusing on facial expression.

Alexei Koulakov

Alexei Koulakov

The complexity of the mammalian brain challenges our ability to explain it. My group applies methods from mathematics and theoretical physics to understand the brain. We are generating novel ideas about neural computation and brain development, including how neurons process information, how brain networks assemble during development, and how brain architecture evolved to facilitate its function.

Bo Li

Bo Li

My group studies the neural circuits underlying cognitive function and dysfunction as they relate to anxiety, depression, schizophrenia and autism. We use sophisticated technologies to manipulate specific neural circuits in the rodent brain to determine their role in behavior. We are interested in changes in synaptic strength that may underlie mental disorders.

Partha Mitra

Partha Mitra

A theoretical physicist by training, my research is centered around intelligent machines. I do both theoretical and experimental work. The theoretical work is focussed on analyzing distributed/networked algorithms in the context of control theory and machine learning, using tools from statistical physics. My lab is involved in brain-wide mesoscale circuit mapping in the Mouse as well as in the Marmoset. An organizing idea behind my research is that there may be common underlying mathematical principles that constrain evolved biological systems and human-engineered systems.

Gabrielle Pouchelon

Gabrielle Pouchelon

Perception and comprehension of the outside world are rooted in our neocortex. How do neurons specialize during development to form complex and very specific circuits to integrating sensory-motor information in adults? My group is interested in the interplay between environmental cues and molecular programs in the assembly of neural circuits.

Stephen Shea

Stephen Shea

When confronted with another individual, social animals use multiple sensory inputs ­ smells, sounds, sights, tastes, touches ­ to choose an appropriate behavioral response. My group studies how specific brain circuits support these natural communication behaviors and how disruptions in these circuits can lead to inappropriate use of social information, as in Autism Spectrum Disorders.

Jessica Tollkuhn

Jessica Tollkuhn

My lab studies how estrogen and testosterone regulate gene expression in the brain. The receptors for these steroid hormones directly bind DNA to turn genes on or off. We have found that sex differences in gene expression are a dynamic readout of hormone actions across the lifespan. We aim to understand how these hormone-regulated genes contribute to sex-variable biology, behavior, and disease risk.

Linda Van Aelst

Linda Van Aelst

Normal cell function relies on coordinated communication between all the different parts of the cell. These communication signals control what a cell does, what shape it takes, and how it interacts with other cells. I study these signaling networks to understand how they guard against cancer and neurological disorders.

Anthony Zador

Anthony Zador

My lab studies how circuitry in the brain gives rise to complex behaviors, one of nature’s great mysteries. We study how the auditory cortex processes sound, and how this is interrupted in autism. We also seek to obtain a wiring diagram of the mouse brain at the resolution of individual neurons. Our unusual approach exploits cheap and rapid “next-gen” gene sequencing technology.