Lloyd Trotman

Lloyd Trotman

Cancer Center Deputy Director of Education

Ph.D., University of Zurich, 2001

trotman@cshl.edu | 516-367-5054

Trotman Lab Website   Faculty Profile

We have recently developed the first genetic mouse model for therapy and analysis of metastatic prostate cancer. Now we can test if and how modern concepts of cancer evolution can outperform the 80-year-old standard of care- hormone deprivation therapy-and turn lethal prostate cancer into a curable disease.

Lloyd Trotman’s recent research path begins at his discovery some years ago that the loss of a single copy of a master tumor suppressing gene called PTEN is sufficient to permit tumors to develop in animal models of prostate cancer. His team later found that complete loss of PTEN paradoxically triggers senescence, an arrested state that delays or blocks cancer development in affected cells. These findings explained why many patients only display partial loss of this tumor suppressor when diagnosed with prostate cancer. Now the team is researching ways to restore the PTEN protein levels in these patients. This therapeutic approach could slow disease progression and thus greatly reduce the need for surgical removal of the prostate or similar drastic interventions that carry the risks of incontinence and impotence. Their second approach to combat prostate cancer is to model the lethal metastatic disease in genetically engineered mice. They are developing a novel approach that allows for quick generation and visualization of metastatic disease. The efficacy of existing and novel late-stage therapies, such as antihormonal therapy, can then be tested and optimized in these animals. At the same time, the Trotman lab is exploring the genome alterations associated with metastatic disease and with resistance to therapy. To this end, they use single- and multicell genome sequencing techniques developed at CSHL by Drs. Wigler and Hicks.

2022 Member, AACR Science Education and Career Advancement Committee
2021 Editorial Board member, The Journal of Cell Biology, Rockefeller Press, NY
2020 Editorial Advisory Board member, The EMBO Journal
2014 Pershing Square Sohn Prize
2014 American Cancer Society Scholar
2008 V Foundation Scholar
2007 Rita Allen Foundation Scholar
2006 ASCB Merton R. Bernfield Memorial Award

See all Trotman news

All Publications

FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer

2024 | Cancers | 16(1):60
M. Swamynathan, Manojit, Mathew, Grinu, Aziz, Andrei, Gordon, Chris, Hillowe, Andrew, Wang, Hehe, Jhaveri, Aashna, Kendall, Jude, Cox, Hilary, Giarrizzo, Michael, Azabdaftari, Gissou, Rizzo, Robert, Diermeier, Sarah, Ojima, Iwao, Bialkowska, Agnieszka, Kaczocha, Martin, Trotman, Lloyd

Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells

2023 | PLoS ONE | 18(10):e0292483
Hillowe, Andrew, Gordon, Chris, Wang, Liqun, Rizzo, Robert, Trotman, Lloyd, Ojima, Iwao, Bialkowska, Agnieszka, Kaczocha, Martin, Pizzo, Salvatore

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Aug 2023 | Nature Cancer | 4(8):1102-1121
Brina, Daniela, Ponzoni, Adele, Troiani, Martina, Calì, Bianca, Pasquini, Emiliano, Attanasio, Giuseppe, Mosole, Simone, Mirenda, Michela, D'Ambrosio, Mariantonietta, Colucci, Manuel, Guccini, Ilaria, Revandkar, Ajinkya, Alajati, Abdullah, Tebaldi, Toma, Donzel, Deborah, Lauria, Fabio, Parhizgari, Nahjme, Valdata, Aurora, Maddalena, Martino, Calcinotto, Arianna, Bolis, Marco, Rinaldi, Andrea, Barry, Simon, Rüschoff, Jan, Sabbadin, Marianna, Sumanasuriya, Semini, Crespo, Mateus, Sharp, Adam, Yuan, Wei, Grinu, Mathew, Boyle, Alexandra, Miller, Cynthia, Trotman, Lloyd, Delaleu, Nicolas, Fassan, Matteo, Moch, Holger, Viero, Gabriella, de Bono, Johann, Alimonti, Andrea

Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology

4 Apr 2023 | Analytical Chemistry | 95(13):5661-5670
Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit, Froeling, Fieke, Trotman, Lloyd, Tuveson, David, Lyons, Scott

PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers

3 Dec 2022 | Molecular Oncology
Aakula, Anna, Isomursu, Aleksi, Rupp, Christian, Erickson, Andrew, Gupta, Nikhil, Kauko, Otto, Shah, Pragya, Padzik, Artur, Pokharel, Yuba, Kaur, Amanpreet, Li, Song-Ping, Trotman, Lloyd, Taimen, Pekka, Rannikko, Antti, Lammerding, Jan, Paatero, Ilkka, Mirtti, Tuomas, Ivaska, Johanna, Westermarck, Jukka

Internally-controlled and dynamic optical measures of functional tumor biology

31 May 2022 | bioRxiv
Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit, Froeling, Fieke, Trotman, Lloyd, Tuveson, David, Lyons, Scott

Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases

16 Nov 2021 | Cell Reports | 37(7):110027
Taranda, Julian, Mathew, Grinu, Watrud, Kaitlin, El-Amine, Nour, Lee, Matthew, Elowsky, Corey, Bludova, Anastasiia, Escobar Avelar, Sintia, Nowak, Dawid, Wee, Tse-Luen, Wilkinson, John, Trotman, Lloyd, Osten, Pavel

Advances in preclinical evaluation of experimental antibody-drug conjugates

4 Jul 2021 | Cancer Drug Resistance | 4:745-754
Lyons, Scott, Plenker, Dennis, Trotman, Lloyd

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

7 Jul 2020 | Journal of Experimental Medicine (JEM) | 217(9)
Oni, T, Biffi, G, Baker, L, Hao, Y, Tonelli, C, Somerville, T, Deschênes, A, Belleau, P, Hwang, C, Sánchez-Rivera, F, Cox, H, Brosnan, E, Doshi, A, Lumia, R, Khaledi, K, Park, Y, Trotman, L, Lowe, S, Krasnitz, A, Vakoc, C, Tuveson, D

Competence against insufficiency: Why are men mostly safe from a rare and deadly prostate cancer?

Jun 2020 | Journal of Experimental Medicine (JEM) | 217(6):e20200087
Mathew, G, Trotman, L

See more publications