Corina Amor Vegas
Assistant Professor
Cancer Center Program Co-Leader
M.D., Ph.D., Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 2021
amor@cshl.edu | 516-367-5504
As we age our body accumulates damaged “senescent” cells that our immune system is no longer able to effectively eliminate. Senescent cells are responsible for the development of aging and age-related diseases like cancer or fibrosis. My group studies how senescent cells evade the immune system thereby identifying new therapeutic approaches.
Our lab studies cellular senescence. Senescence is a stress response program that is triggered in damaged cells and leads to their elimination by the immune system. If uncleared, the accumulation of senescent cells generates a chronic pro-inflammatory microenvironment that conduces to aging and tumor development. We seek to understand how the immune system recognizes and targets these cells in physiological conditions and how senescent cells evade immune clearance in disease. We aim to leverage our findings to develop immune-based therapeutic approaches to target senescent cells in cancer, aging and age-related pathologies. In our studies we develop and combine novel somatic mouse models of cancer and cell-based therapeutics such as our recently developed senolytic CAR T cells.
The 2024 CSHL Raft Race
November 12, 2024
Ten teams brave cool harbor waters, the hot August sun, and new boat-building rules in the 9th annual CSHL Raft Race.
CSHL’s oldest haunts
October 31, 2024
These buildings have weathered oceans of time to be here. Pull back the veil and cross over into CSHL’s storied past for a closer look.
23rd Annual Women’s Partnership for Science raises over $360,000
October 10, 2024
CSHL's 23rd annual Women’s Partnership for Science Lecture and Luncheon raised over $360,000 for scientific research.
Making headlines
September 11, 2024
Several Cold Spring Harbor Laboratory faculty members received national mainstream media attention in 2024.
Cocktails & Chromosomes: Why do we age?
July 18, 2024
Humans have asked this question since the dawn of civilization. Today, we have the answer. Find out about this and more from CSHL’s Corina Amor Vegas.
From novel discovery to anti-aging therapy
February 8, 2024
Former CSHL Fellow Carol Greider’s Nobel-winning research has led to new cancer treatments. Now, it’s helping us unravel the mysteries of aging.
A quiz for the ages
January 29, 2024
Want to know the secret to a long life? So do CSHL scientists. Take this short quiz to see what they’ve found out about aging and longevity.
The fountain of youth is … a T cell?
January 24, 2024
CSHL's Corina Amor Vegas discovers that CAR T cells can act as a “living” drug, causing young mice to age more slowly and old mice to rejuvenate.
Inside a Nobelist’s notebooks
December 13, 2023
Carol Greider’s lab writings offer a firsthand look at her Nobel Prize-winning research—work that continues today in CSHL’s Amor Vegas lab.
CSHL celebrates 50th anniversary of McClintock Laboratory
November 20, 2023
Fifty years ago, CSHL honored Barbara McClintock by dedicating a building in her name. Today, it is home to four innovative cancer labs.
All Publications
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
28 Sep 2024 | Cell Death and Disease | 15(9):694
Murga, Matilde; Lopez-Pernas, Gema; Soliva, Robert; Fueyo-Marcos, Elena; Amor, Corina; Faustino, Ignacio; Serna, Marina; Serrano, Alicia; Díaz, Lucía; Martínez, Sonia; Blanco-Aparicio, Carmen; Antón, Marta; Seashore-Ludlow, Brinton; Pastor, Joaquín; Jafari, Rozbeh; Lafarga, Miguel; Llorca, Oscar; Orozco, Modesto; Fernández-Capetillo, Oscar;
A brain-body feedback loop driving HPA-axis dysfunction in breast cancer
14 Sep 2024 | bioRxiv
Gomez, Adrian; Wu, Yue; Zhang, Chao; Boyd, Leah; Wee, Tse-Luen; Gewolb, Joseph; Amor, Corina; Cheadle, Lucas; Borniger, Jeremy;
SGLT2 regulates immune-mediated senolysis
10 Jun 2024 | Nature Aging
Guo, Guangran; Amor, Corina;
eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer
11 May 2024 | bioRxiv
Boyer, Jacob; Sharma, Malvika; Dorso, Madeline; Mai, Nicholas; Amor, Corina; Reiter, Jason; Kannan, Ram; Gadal, Sunyana; Xu, Jianing; Miele, Matthew; Zhuoning, Li; Chen, Xiaoping; Chang, Qing; Pareja, Fresia; Worland, Stephan; Warner, Douglas; Sperry, Sam; Chiang, Gary; Thompson, Peggy; Yang, Guangli; Ouerfelli, Ouathek; De Stanchina, Elisa; Wendel, Hans; Rosen, Ezra; Chandarlapaty, Sarat; Rosen, Neal;
Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness
22 Mar 2024 | bioRxiv
Eskiocak, Onur; Chowdhury, Saria; Shah, Vyom; Nnuji-John, Emmanuella; Chung, Charlie; Boyer, Jacob; Harris, Alexander; Habel, Jill; Sadelain, Michel; Beyaz, Semir; Amor, Corina;
Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies.
Mar 2024 | Nature | 627(8004):E9
Amor, Corina; Feucht, Judith; Leibold, Josef; Ho, Yu-Jui; Zhu, Changyu; Alonso-Curbelo, Direna; Mansilla-Soto, Jorge; Boyer, Jacob; Li, Xiang; Giavridis, Theodoros; Kulick, Amanda; Houlihan, Shauna; Peerschke, Ellinor; Friedman, Scott; Ponomarev, Vladimir; Piersigilli, Alessandra; Sadelain, Michel; Lowe, Scott;
Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease
18 Mar 2024 | Journal of Hepatology | :S0168-8278(24)00197
Yashaswini, Chittampalli; Qin, Tianyue; Bhattacharya, Dipankar; Amor, Corina; Lowe, Scott; Lujambio, Amaia; Wang, Shuang; Friedman, Scott;
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
24 Jan 2024 | Nature Aging
Amor, Corina; Fernández-Maestre, Inés; Chowdhury, Saria; Ho, Yu-Jui; Nadella, Sandeep; Graham, Courtenay; Carrasco, Sebastian; Nnuji-John, Emmanuella; Feucht, Judith; Hinterleitner, Clemens; Barthet, Valentin; Boyer, Jacob; Mezzadra, Riccardo; Wereski, Matthew; Tuveson, David; Levine, Ross; Jones, Lee; Sadelain, Michel; Lowe, Scott;
Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
4 Jan 2024 | Nature Cancer
Leibold, Josef; Tsanov, Kaloyan; Amor, Corina; Ho, Yu-Jui; Sánchez-Rivera, Francisco; Feucht, Judith; Baslan, Timour; Chen, Hsuan-An; Tian, Sha; Simon, Janelle; Wuest, Alexandra; Wilkinson, John; Lowe, Scott;
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
26 Sep 2023
Amor, Corina; Fernández-Maestre, Inés; Chowdhury, Saria; Ho, Yu-Jui; Nadella, Sandeep; Graham, Courtenay; Carrasco, Sebastian; Nnuji-John, Emmanuella; Feucht, Judith; Hinterleitner, Clemens; Barthet, Valentin; Boyer, Jacob; Mezzadra, Riccardo; Wereski, Matthew; Tuveson, David; Levine, Ross; Jones, Lee; Sadelain, Michel; Lowe, Scott;