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Scott Lyons

Scott Lyons

Research Associate Professor/Director Animal Imaging
Cancer Center Member

Ph.D., University of Edinburgh, 1999

slyons@cshl.edu | 516-367-5053

Faculty Profile

I provide collaborative research support to CSHL researchers in the area of preclinical in vivo imaging. This includes access to a comprehensive range of imaging modalities, as well as provision of experimental guidance, training and imaging reagents. In addition, my lab develops new and impactful ways to image aspects of in vivo tumor biology that are broadly relevant to the development of new therapeutics and the research interests of the CSHL Cancer Center.

The ability to measure cancer biology non-invasively in vivo has revolutionized preclinical research. It enables the researcher to make repeated measurements of the same tumor over time and to dynamically visualize aspects of its development or response to treatment. This greatly enhances the quality of experimental data and reduces the number of animals needed per study. In addition to providing general imaging support, we also develop new and innovative ways to image tumors, such as their cellular proliferation or metastatic spread, with the ultimate goal of discovering effective treatments and better understanding their mechanism of action.

All Publications

Evaluating possible maternal effect lethality of Naa10 knockout mice, and modulation of phenotypes for embryonic and neonatal lethality by genetic background and environment

27 Apr 2023 | Cold Spring Harbor Laboratory
Lyon, Gholson, Longo, Joseph, Garcia, Andrew, Inusa, Fatima, Marchi, Elaine, Shi, Daniel, Dörfel, Max, Arnesen, Thomas, Aldabe, Rafael, Lyons, Scott, Nashat, Melissa, Bolton, David

Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells.

26 Apr 2023 | MedChemComm | 14(4):710-714
Gialelis, Timothy, Wang, Zifei, Homer, Joshua, Yang, Wen-Hsuan, Chung, Taemoon, Hu, Qingting, Smedley, Christopher, Pawar, Nitin, Upadhyay, Nitinkumar, Tuveson, David, Lyons, Scott, Lukey, Michael, Moses, John

Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology.

4 Apr 2023 | Analytical Chemistry | 95(13):5661-5670
Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit, Froeling, Fieke, Trotman, Lloyd, Tuveson, David, Lyons, Scott

BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network

21 Dec 2022 | Nature
Sun, Xueqin, Klingbeil, Olaf, Lu, Bin, Wu, Caizhi, Ballon, Carlos, Ouyang, Meng, Wu, Xiaoli, Jin, Ying, Hwangbo, Yon, Huang, Yu-Han, Somerville, Tim, Chang, Kenneth, Park, Jung, Chung, Taemoon, Lyons, Scott, Shi, Junwei, Vogel, Hannes, Schulder, Michael, Vakoc, Christopher, Mills, Alea

Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment

7 Nov 2022 | Developmental Cell | 57(21):2450-2468.e7
Hazra, Rasmani, Brine, Lily, Garcia, Libia, Benz, Brian, Chirathivat, Napon, Shen, Michael, Wilkinson, John, Lyons, Scott, Spector, David

Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma.

Sep 2022 | Laboratory Investigation | 102(9):1038-1049
Safaric Tepes, Polona, Segovia, Danilo, Jevtic, Sania, Ramirez, Daniel, Lyons, Scott, Sordella, Raffaella

PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils

22 Jul 2022 | JCI Insight | 7(14):e158199
Song, Dongyan, Adrover, Jose, Felice, Christy, Christensen, Lisa, He, Xue-Yan, Merrill, Joseph, Wilkinson, John, Janowitz, Tobias, Lyons, Scott, Egeblad, Mikala, Tonks, Nicholas

Internally-controlled and dynamic optical measures of functional tumor biology

31 May 2022 | bioRxiv
Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit, Froeling, Fieke, Trotman, Lloyd, Tuveson, David, Lyons, Scott

Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection.

8 Feb 2022 | JCI Insight
Adrover, Jose, Carrau, Lucia, Daßler-Plenker, Juliane, Bram, Yaron, Chandar, Vasuretha, Houghton, Sean, Redmond, David, Merrill, Joseph, Shevik, Margaret, tenOever, Benjamin, Lyons, Scott, Schwartz, Robert, Egeblad, Mikala

Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma

26 Nov 2021 | Laboratory Investigation
Safaric Tepes, Polona, Segovia, Danilo, Jevtic, Sania, Ramirez, Daniel, Lyons, Scott, Sordella, Raffaella

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