I provide collaborative research support to CSHL researchers in the area of preclinical in vivo imaging. This includes access to a comprehensive range of imaging modalities, as well as provision of experimental guidance, training and imaging reagents. In addition, my lab develops new and impactful ways to image aspects of in vivo tumor biology that are broadly relevant to the development of new therapeutics and the research interests of the CSHL Cancer Center.
The ability to measure cancer biology non-invasively in vivo has revolutionized preclinical research. It enables the researcher to make repeated measurements of the same tumor over time and to dynamically visualize aspects of its development or response to treatment. This greatly enhances the quality of experimental data and reduces the number of animals needed per study. In addition to providing general imaging support, we also develop new and innovative ways to image tumors, such as their cellular proliferation or metastatic spread, with the ultimate goal of discovering effective treatments and better understanding their mechanism of action.
Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection.
8 Feb 2022 | JCI Insight
Adrover, Jose, Carrau, Lucia, Daßler-Plenker, Juliane, Bram, Yaron, Chandar, Vasuretha, Houghton, Sean, Redmond, David, Merrill, Joseph, Shevik, Margaret, tenOever, Benjamin, Lyons, Scott, Schwartz, Robert, Egeblad, Mikala
Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma
26 Nov 2021 | Laboratory Investigation
Safaric Tepes, Polona, Segovia, Danilo, Jevtic, Sania, Ramirez, Daniel, Lyons, Scott, Sordella, Raffaella
6 Aug 2021 | eLife | 10
Kweon, Hyae, Lee, Mi-Ni, Dorfel, Max, Seo, Seungwoon, Gottlieb, Leah, PaPazyan, Thomas, McTiernan, Nina, Ree, Rasmus, Bolton, David, Garcia, Andrew, Flory, Michael, Crain, Jonathan, Sebold, Alison, Lyons, Scott, Ismail, Ahmed, Marchi, Elaine, Sonn, Seong-Keun, Jeong, Se-Jin, Jeon, Sejin, Ju, Shinyeong, Conway, Simon, Kim, Taesoo, Kim, Hyun-Seok, Lee, Cheolju, Roh, Tae-Young, Arnesen, Thomas, Marmorstein, Ronen, Oh, Gootaeg, Lyon, Gholson
4 Jul 2021 | Cancer Drug Resistance | 4:745-754
Lyons, Scott, Plenker, Dennis, Trotman, Lloyd
10 Sep 2020 | bioRxiv
Oni, Tobiloba, Bautista, Carmelita, Merrill, Joseph, Goos, Jeroen, Rivera, Keith, Miyabayashi, Koji, Biffi, Giulia, Garcia, Libia, Plenker, Dennis, Patel, Hardik, Elyada, Ela, Samaritano, Maria, Yu, Kenneth, Pappin, Darryl, Goggins, Michael, Hruban, Ralph, Lewis, Jason, Lyons, Scott, Yeh, Johannes, Tuveson, David
A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue
16 Aug 2019 | Nature Protocols | 14(9):2648-2671
Lenos, K, Lodestijn, S, Lyons, S, Bijlsma, M, Miedema, D, Vermeulen, L
28 Sep 2018 | Science | 361(6409)
Albrengues, J, Shields, M, Ng, D, Park, C, Ambrico, A, Poindexter, M, Upadhyay, P, Uyeminami, D, Pommier, A, Kuttner, V, Bruzas, E, Maiorino, L, Bautista, C, Carmona, E, Gimotty, P, Fearon, D, Chang, K, Lyons, S, Pinkerton, K, Trotman, L, Goldberg, M, Yeh, J, Egeblad, M
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
3 Sep 2018 | Nature Cell Biology | 20(10):1193-1202
Lenos, K, Miedema, D, Lodestijn, S, Nijman, L, van den Bosch, T, Romero Ros, X, Lourenco, F, Lecca, M, van der Heijden, M, van Neerven, S, van Oort, A, Leveille, N, Adam, R, de Sousa, E, Otten, J, Veerman, P, Hypolite, G, Koens, L, Lyons, S, Stassi, G, Winton, D, Medema, J, Morrissey, E, Bijlsma, M, Vermeulen, L
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
17 May 2018 | Science | 360(394)
Pommier, A, Anaparthy, N, Memos, N, Kelley, Z, Gouronnec, A, Yan, R, Auffray, C, Albrengues, J, Egeblad, M, Iacobuzio-Donahue, C, Lyons, S, Fearon, D
[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.
2018 | Theranostics | 8(14):3991-4002
Lewis, David, Mair, Richard, Wright, Alan, Allinson, Kieren, Lyons, Scott, Booth, Tom, Jones, Julia, Bielik, Robert, Soloviev, Dmitry, Brindle, Kevin