CSHL Cancer Center - Signal Transduction
The Signal Transduction Program is exploring the molecular signals within and between cells that drive cancer. These researchers are developing innovative new models for human tumors and advanced imaging technology with a goal of identifying potential “druggable” targets and mechanisms of drug resistance in cancer. Current research is focused on identifying and targeting the signaling mechanisms and tumor-host interactions that drive cancer.
Krishnan, N. and Krishnan, K. and Connors, C. R. and Choy, M. S. and Page, R. and Peti, W. and Van Aelst, L. and Shea, S. D. and Tonks, N. K. (2015) PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest 125(8) pp. 3163-3177.
Palm, W. and Park, Y. and Wright, K. and Pavlova, N. N. and Tuveson, D. A. and Thompson, C. B. (2015) The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell 162(2) pp. 259-270.
Roe, Jae-Seok and Mercan, Fatih and Rivera, Keith and Pappin, Darryl J and Vakoc, Christopher R (2015) BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia. Molecular Cell 58(6) pp. 1028-1036.
Akerman, M. and Fregoso, O. I. and Das, S. and Ruse, C. and Jensen, M. A. and Pappin, D. J. and Zhang, M. Q. and Krainer, A. R. (2015) Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol 16(1) pp. 119.
Saiyin, H. and Ardito-Abraham, C. M. and Wu, Y. and Wei, Y. and Fang, Y. and Han, X. and Li, J. and Zhou, P. and Yi, Q. and Maitra, A. and Liu, J. O. and Tuveson, D. A. and Lou, W. and Yu, L. (2015) Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma. J Pathol 236(2) pp. 142-154.
Trotman, L. C. and Nowak, D. G. and Cho, H. and Herzka, T. and Watrud, K. and DeMarco, D. V. and Wang, V. M. and Senturk, S. and Fellmann, C. and Ding, D. and Beinortas, T. and Kleinman, D. and Chen, M. and Sordella, R. and Wilkinson, J. E. and Castillo-Martin, M. and Cordon-Cardo, C. and Robinson, B. D. (2015) Myc drives Pten/trp53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2. Cancer Discovery 5(6) pp. 636-651.
Fan, G. and Aleem, S. and Yang, M. and Miller, W. T. and Tonks, N. K. (2015) Protein Tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and BRK. Journal of Biological Chemistry 290(26) pp. 15934-15947.
Klingler, S. and Guo, B. and Yao, J. and Yan, H. and Zhang, L. and Vaseva, A. V. and Chen, S. and Canoll, P. and Horner, J. W. and Wang, Y. A. and Paik, J. H. and Ying, H. and Zheng, H. (2015) Development of resistance to EGFR targeted therapy in malignant glioma can occur through EGFR dependent and independent mechanisms. Cancer Research 75(10) pp. 2109-2119.
Park, Jae-Hyun and Rasch, Morten Grønbech and Qiu, Jing and Lund, Ida Katrine and Egeblad, Mikala (2015) Presence of Insulin-Like Growth Factor Binding Proteins Correlates With Tumor-Promoting Effects of Matrix Metalloproteinase 9 in Breast Cancer. Neoplasia 17(5) pp. 421-433.
Ramesh, M. and Krishnan, N. and Muthuswamy, S. K. and Tonks, N. K. (2015) A Novel Phosphatidic Acid-Protein Tyrosine Phosphatase D2 Axis is Essential for ERBB2 Signaling in Mammary Epithelial Cells. Journal of Biological Chemistry 290(15) pp. 9646-9659.
Naguib, Adam and Bencze, Gyula and Cho, Hyejin and Zheng, Wu and Tocilj, Ante and Elkayam, Elad and Faehnle, Christopher R and Jaber, Nadia and Pratt, Christopher P and Chen, Muhan and Zong, Wei-Xing and Marks, Michael S and Joshua-Tor, Leemor and Pappin, Darryl J and Trotman, Lloyd C (2015) PTEN Functions by Recruitment to Cytoplasmic Vesicles. Molecular Cell 58(2) pp. 255-268.
Dos Santos, L. I. and Galvao-Filho, B. and de Faria, P. C. and Junqueira, C. and Dutra, M. S. and Teixeira, S. M. and Rodrigues, M. M. and Ritter, G. and Bannard, O. and Fearon, D. T. and Antonelli, L. R. and Gazzinelli, R. T. (2015) Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother 64(3) pp. 311-23.
Yu, J. R. and Tai, Y. and Jin, Y. and Hammell, M. C. and Wilkinson, J. E. and Roe, J. S. and Vakoc, C. R. and Van Aelst, L. (2015) TGF-beta/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev 29(3) pp. 250-61.
Fan, G. and Wrzeszczynski, K. O. and Fu, C. and Su, G. and Pappin, D. J. and Lucito, R. and Tonks, N. K. (2015) A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines. Biochem J 465(3) pp. 433-42.
Perna, D. and Karreth, F. A. and Rust, A. G. and Perez-Mancera, P. A. and Rashid, M. and Iorio, F. and Alifrangis, C. and Arends, M. J. and Bosenberg, M. W. and Bollag, G. and Tuveson, D. A. and Adams, D. J. (2015) BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proceedings of the National Academy of Sciences of the United States of America 112(6) pp. E536-E545.
Crompton, J. G. and Sukumar, M. and Roychoudhuri, R. and Clever, D. and Gros, A. and Eil, R. L. and Tran, E. and Hanada, K. and Yu, Z. and Palmer, D. C. and Kerkar, S. P. and Michalek, R. D. and Upham, T. and Leonardi, A. and Acquavella, N. and Wang, E. and Marincola, F. M. and Gattinoni, L. and Muranski, P. and Sundrud, M. S. and Klebanoff, C. A. and Rosenberg, S. A. and Fearon, D. T. and Restifo, N. P. (2015) Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. Cancer Res 75(2) pp. 296-305.
Gampe, K. and Stefani, J. and Hammer, K. and Brendel, P. and Potzsch, A. and Enikolopov, G. and Enjyoji, K. and Acker-Palmer, A. and Robson, S. C. and Zimmermann, H. (2015) NTPDase2 and Purinergic Signaling Control Progenitor Cell Proliferation in Neurogenic Niches of the Adult Mouse Brain. Stem Cells 33(1) pp. 253-64.
Boj, Sylvia F and Hwang, Chang-Il and Baker, Lindsey A and Chio, Iok In Christine and Engle, Dannielle D and Corbo, Vincenzo and Jager, Myrthe and Ponz-Sarvise, Mariano and Tiriac, Hervé and Spector, Mona S and Gracanin, Ana and Oni, Tobiloba and Yu, Kenneth H and van Boxtel, Ruben and Huch, Meritxell and Rivera, Keith D and Wilson, John P and Feigin, Michael E and Öhlund, Daniel and Handly-Santana, Abram and Ardito-Abraham, Christine M and Ludwig, Michael and Elyada, Ela and Alagesan, Brinda and Biffi, Giulia and Yordanov, Georgi N and Delcuze, Bethany and Creighton, Brianna and Wright, Kevin and Park, Youngkyu and Morsink, Folkert H M. and Molenaar, I. Quintus and Borel Rinkes, Inne H and Cuppen, Edwin and Hao, Yuan and Jin, Ying and Nijman, Isaac J and Iacobuzio-Donahue, Christine and Leach, Steven D and Pappin, Darryl J and Hammell, Molly and Klimstra, David S and Basturk, Olca and Hruban, Ralph H and Offerhaus, George Johan and Vries, Robert G J. and Clevers, Hans and Tuveson, David A (2015) Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell 160(1-2) pp. 324-338.
Schlomann, U. and Koller, G. and Conrad, C. and Ferdous, T. and Golfi, P. and Garcia, A. M. and Hofling, S. and Parsons, M. and Costa, P. and Soper, R. and Bossard, M. and Hagemann, T. and Roshani, R. and Sewald, N. and Ketchem, R. R. and Moss, M. L. and Rasmussen, F. H. and Miller, M. A. and Lauffenburger, D. A. and Tuveson, D. A. and Nimsky, C. and Bartsch, J. W. (2015) ADAM8 as a drug target in pancreatic cancer. Nature Communications 6pp. 6175.Additional materials of the author at
CSHL Institutional Repository
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