How does the brain encode stimuli from the outside world to give rise to perceptions? What does a smell look like in the brain? The focus of my group is to understand how neural circuits compute sensory-motor transformations across different contexts, senses, and brain states to generate meaningful behaviors.
How does the brain encode stimuli from the outside world, within and across sensory modalities, to generate specific perceptions that trigger complex behaviors? How is the brain shaped by sensory experience, and what modifications occur in neuronal circuits that allow us to learn and remember? These are the questions guiding the work of Florin Albeanu, who is using the olfactory bulb and olfactory cortex of mice as the subject of his current studies. Airborne chemicals, translated into neuronal signals by specific receptors in the nose, are sent directly to the olfactory bulb. Advances in optical imaging and optogenetics combined with electrophysiological recordings enable Albeanu and colleagues to monitor and/or alter patterns of activity at unprecedented synaptic and millisecond resolution, in real time, as animals are engaged in various behaviors. For survival, rodents need to identify the smells of objects of interest such as food, mates, and predators, across their recurring appearances in the surroundings, despite apparent variations in their features. Furthermore, animals aptly extract relevant information about environment across different sensory modalities, combining olfactory, visual, or auditory cues. By recording neuronal activity in the input and output layers of the olfactory bulb, as well as feedback from olfactory cortical areas and neuromodulatory signals, Albeanu and his team aim to understand computations the bulb performs and how this information is decoded deeper in the brain. They have recently published evidence suggesting that the mouse olfactory bulb is not merely a relay station between the nose and cortex, as many have supposed. Using optogenetic tools and a novel patterned illumination technique, they discovered that there are many more information output channels leaving the olfactory bulb for the cortex than there are inputs received from the nose. They are currently investigating how this diversity of bulb outputs is generated, as well as how downstream areas, such as the piriform and parietal cortex, make use of such information during behaviors.
Kebschull, Justus M and Garcia da Silva, Pedro and Reid, Ashlan P and Peikon, Ian D and Albeanu, Dinu F and Zador, Anthony M (2016) High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA. Neuron, 91(5) pp. 975-987.
Yu, K. and Garcia da Silva, P. and Albeanu, D. F. and Li, B. (2016) Central Amygdala Somatostatin Neurons Gate Passive and Active Defensive Behaviors. J Neurosci, 36(24) pp. 6488-96.
Banerjee, A. and Marbach, F. and Anselmi, F. and Koh, M. S. and Davis, M. B. and Garcia da Silva, P. and Delevich, K. and Oyibo, H. K. and Gupta, P. and Li, B. and Albeanu, D. F. (2015) An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb. Neuron, 87(1) pp. 193-207.
Otazu, Gonzalo H and Chae, Honggoo and Davis, Martin B and Albeanu, Dinu F (2015) Cortical Feedback Decorrelates Olfactory Bulb Output in Awake Mice. Neuron, 86(6) pp. 1461-1477.
Gupta, P. and Albeanu, D. F. and Bhalla, U. S. (2015) Olfactory bulb coding of odors, mixtures and sniffs is a linear sum of odor time profiles. Nature Neuroscience, 18 pp. 272-281.
Anselmi, Francesca and Banerjee, Arkarup and Albeanu, Dinu F. (2015) Patterned Photostimulation in the Brain. In: New Techniques in Systems Neuroscience. Douglass, Adam D. (Ed.). pp. 235-270. Cham: Springer International Publishing.
Spors, H. and Albeanu, D. F. and Murthy, V. N. and Rinberg, D. and Uchida, N. and Wachowiak, M. and Friedrich, R. W. (2012) Illuminating Vertebrate Olfactory Processing. Journal of Neuroscience, 32(41) pp. 14102-14108.
Dhawale, A. K. and Hagiwara, A. and Bhalla, U. S. and Murthy, V. N. and Albeanu, D. F. (2010) Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse. Nature Neuroscience, 13 pp. 1404-12.
Soucy, E. R. and Albeanu, D. F. and Fantana, A. L. and Murthy, V. N. and Meister, M. (2009) Precision and diversity in an odor map on the olfactory bulb. Nature Neuroscience, 12(2) pp. 210-220.Additional materials of the author at
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