Dinu Florin Albeanu

Dinu Florin Albeanu


Ph.D., Harvard University, 2008

albeanu@cshl.edu | 516-367-8822

Albeanu Lab Website   Faculty Profile

How does the brain encode stimuli from the outside world to give rise to perceptions? What does a smell look like in the brain? The focus of my group is to understand how neural circuits compute sensory-motor transformations across different contexts, senses, and brain states to generate meaningful behaviors.

How does the brain encode stimuli from the outside world, within and across sensory modalities, to generate specific perceptions that trigger complex behaviors? How is the brain shaped by sensory experience, and what modifications occur in neuronal circuits that allow us to learn and remember? These are the questions guiding the work of Florin Albeanu, who is using the olfactory bulb and olfactory cortex of mice as the subject of his current studies. Airborne chemicals, translated into neuronal signals by specific receptors in the nose, are sent directly to the olfactory bulb. Advances in optical imaging and optogenetics combined with electrophysiological recordings enable Albeanu and colleagues to monitor and/or alter patterns of activity at unprecedented synaptic and millisecond resolution, in real time, as animals are engaged in various behaviors. For survival, rodents need to identify the smells of objects of interest such as food, mates, and predators, across their recurring appearances in the surroundings, despite apparent variations in their features. Furthermore, animals aptly extract relevant information about environment across different sensory modalities, combining olfactory, visual, or auditory cues. By recording neuronal activity in the input and output layers of the olfactory bulb, as well as feedback from olfactory cortical areas and neuromodulatory signals, Albeanu and his team aim to understand computations the bulb performs and how this information is decoded deeper in the brain. They have recently published evidence suggesting that the mouse olfactory bulb is not merely a relay station between the nose and cortex, as many have supposed. Using optogenetic tools and a novel patterned illumination technique, they discovered that there are many more information output channels leaving the olfactory bulb for the cortex than there are inputs received from the nose. They are currently investigating how this diversity of bulb outputs is generated, as well as how downstream areas, such as the piriform and parietal cortex, make use of such information during behaviors.

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Selected Publications

A non-canonical feedforward pathway for computing odor identity

30 Sep 2020 | bioRxiv
Banerjee, Arkarup, Chae, Honggoo, Albeanu, D

Mosaic representations of odors in the input and output layers of the mouse olfactory bulb

Aug 2019 | Nature Neuroscience | 22(8):1306-1317.
Chae, H, Kepple, D, Bast, W, Murthy, V, Koulakov, A, Albeanu, D

Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map

29 Nov 2018 | Nature Communications | 9(1):5073
Albeanu, D, Provost, A, Agarwal, P, Soucy, E, Zak, J, Murthy, V

Olfactory marker protein (OMP) regulates refinement of the olfactory glomerular map

May 2018 | bioRxiv
Albeanu, Dinu, Provost, Allison, Agarwal, Prateek, Soucy, Edward, Murthy, Venkatesh

All Publications

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

23 Nov 2022 | eLife | 11:e78815
Szadai, Zoltán, Pi, Hyun-Jae, Chevy, Quentin, Ócsai, Katalin, Albeanu, Dinu, Chiovini, Balázs, Szalay, Gergely, Katona, Gergely, Kepecs, Adam, Rózsa, Balázs

High-throughput sequencing of single neuron projections reveals spatial organization in the olfactory cortex

27 Oct 2022 | Cell | 185(22):4117-4134.e28
Chen, Yushu, Chen, Xiaoyin, Baserdem, Batuhan, Zhan, Huiqing, Li, Yan, Davis, Martin, Kebschull, Justus, Zador, Anthony, Koulakov, Alexei, Albeanu, Dinu

Long-range functional loops in the mouse olfactory system and their roles in computing odor identity

26 Sep 2022 | Neuron | :S0896-6273(22)00810
Chae, Honggoo, Banerjee, Arkarup, Dussauze, Marie, Albeanu, Dinu

Mapping odorant receptors to their glomeruli

21 Mar 2022 | Nature Neuroscience
Bast, Walter, Albeanu, Dinu

Wiring logic of the early rodent olfactory system revealed by high-throughput sequencing of single neuron projections

2021 | bioRxiv
Chen, Yushu, Chen, Xiaoyin, Baserdem, Batuhan, Zhan, Huiqing, Li, Yan, Davis, Martin, Kebschull, Justus, Zador, Anthony, Koulakov, Alexei, Albeanu, Dinu

Long-range interactions between short axon cells and external tufted cells gate glomerular output in the mouse olfactory bulb.

1 Jul 2017 | Neuron | 87(1):193-207
Banerjee, Arkarup, Marbach, F, Anselmi, Francesca, Koh, Matthew, Davis, Martin, Garcia da Silva, P, Delevich, K, Oyibo, Hassana, Gupta, Priyanka, Li, Bo, Albeanu, Dinu

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