
When confronted with another individual, social animals use multiple sensory inputs smells, sounds, sights, tastes, touches to choose an appropriate behavioral response. My group studies how specific brain circuits support these natural communication behaviors and how disruptions in these circuits can lead to inappropriate use of social information, as in Autism Spectrum Disorders.
Stephen Shea’s lab studies the neural circuitry underlying social communication and decisions. He uses natural social communication behavior in mice as a model to understand circuits and processes that are evolutionarily conserved and therefore shared broadly across species, likely contributing to disorders such as autism. Shea and colleagues have examined how emotion and arousal enable mice, via their olfactory systems, to store memories of other individuals and of related social signals. The team has exploited the intimate relationship between memory and emotion to effectively create memories in anesthetized mice, allowing them unprecedented access to neurobiological processes that typically only occur during behavior. The lab has been making a detailed analysis of the changes in neural connections that underlie odor memory. The team is particularly focused on an enigmatic cell type (granule cells or GCs) that has long been hypothesized to be crucial for memories, but has resisted direct study. They have developed methods for recording, giving them the first glimpse of the dynamics of these cells while the animal is learning an odor. The results show unexpectedly complex population dynamics among the GCs that were independently predicted by a model of odor learning developed in Alexei Koulakov’s lab. The two labs are collaborating to discern how GC population activity gets integrated by olfactory bulb output neurons and to pinpoint the synaptic circuit that underlies this form of learning. In parallel, another member of the lab is using imaging techniques to determine how memories are stored among broad neuronal ensembles, at a different level of the system. Recently, the lab made a key breakthrough, developing the ability to record from GCs in awake animals and discovering that their activity is dramatically modulated by state of consciousness. Finally, the Shea lab completed a series of studies of a different form of social recognition: auditory recognition of pup vocalizations by their mothers. Through this research, they have shown that a mouse model of Rett syndrome exhibits deficits in communication and learning not unlike those in human patients. Grants from the Simons and Whitehall Foundations are allowing the lab to extend this work by directly linking these deficits to the action of the gene MeCP2 in the auditory cortex.
Cold Spring Harbor Laboratory 2022 Ph.D.’s
May 1, 2022
The School of Biological Sciences awarded Ph.D. degrees to ten students this year. Here are some stories and memories from their time at CSHL.
Mom’s protective behaviors run deep
March 24, 2022
Neuroscientists found an ancient part of the mouse brain may coordinate maternal protective behaviors.
CSHL Ph.D. program: Graduating class of 2021
August 22, 2021
The CSHL School of Biological Sciences awarded Ph.D. degrees to seven students this year, who describe some of their experiences.
Abnormal neuron activity manifests as parental neglect
January 8, 2020
Without the gene Mecp2, mice can’t learn to care for crying pups. Knowing when the brain is able to learn may help treat developmental disorders.
CSHL postdocs receive NARSAD Young Investigator Grants
October 30, 2019
Two CSHL neuroscience postdocs conducting neurobiological and psychiatric research received the 2019 NARSAD Young Investigators grant.
Portrait of a Neuroscience Powerhouse
April 27, 2018
A relatively small neuroscience group at CSHL is having an outsized impact on a dynamic and highly competitive field
In mouse model of Rett syndrome, research reveals how adult learning is impaired in females
January 18, 2017
Researchers found that the failure of the Mecp2 gene, which leads to Rett syndrome, has biological consequences later in life.
A new way to fear: Lady lab rats raise important questions for behavioral research
January 12, 2016
A discussion of female rats as research subjects and how their hormonal cycle comes into play.
Connecting the dots in Rett Syndrome
July 13, 2015
Stephen Shea speaks about 'Connecting the Dots in Rett Syndrome' at Cold Spring Harbor Laboratory's 125th Anniversary Open House.
Research reveals first glimpse of a brain circuit that helps experience to shape perception
March 2, 2014
For the first time, scientists monitor inhibitory neurons that link sense of smell with memory and cognition in mice
All Publications
Precise and pervasive phasic bursting in locus coeruleus during maternal behavior in mice
22 Feb 2022 | The Journal of Neuroscience
Dvorkin, Roman, Shea, Stephen
Multisensory integration of social signals by a pathway from the basal amygdala to the auditory cortex in maternal mice
17 Feb 2022 | bioRxiv
Nowlan, Alexandra, Kelahan, Clancy, Shea, Stephen
Neurotensin neurons in the central extended amygdala control energy balance
4 Aug 2021 | bioRxiv
Furlan, Alessandro, Corona, Alberto, Boyle, Sara, Sharma, Radhashree, Rubino, Rachel, Habel, Jill, Gablenz, Eva, Giovanniello, Jacqueline, Beyaz, Semir, Janowitz, Tobias, Shea, Stephen, Li, Bo
Precise and pervasive phasic bursting in locus coeruleus during maternal behavior
1 Apr 2021 | bioRxiv
Dvorkin, Roman, Shea, Stephen
Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires MECP2
6 Jan 2020 | The Journal of Neuroscience | 40(7):1514-1526
Lau, B, Krishnan, K, Huang, Z, Shea, S
Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires MECP2
30 May 2019 | BioRxiv
Lau, Billy, Krishnan, Keerthi, Huang, Josh, Shea, Stephen
Computational algorithms and neural circuitry for compressed sensing in the mammalian main olfactory bulb
5 Jun 2018 | BioRxiv
Kepple, Daniel, Cazakoff, Brittany, Demmer, Heike, Eckmeier, Dennis, Shea, Stephen, Koulakov, Alexei
MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
18 Jan 2017 | Nature Communications | 8:14077
Krishnan, K, Lau, B, Ewall, G, Huang, Z, Shea, S
MECP2 regulates cortical plasticity underlying a learned behavior in adult female mice
28 Feb 2016 | BioRxiv
Krishnan, Keerthi, Lau, Billy, Ewall, Gabrielle, Huang, Josh, Shea, Stephen
Whole-Brain Mapping of Neuronal Activity in the Learned Helplessness Model of Depression
3 Feb 2016 | Frontiers in Neural Circuits | 10
Kim, Y, Perova, Z, Mirrione, M, Pradhan, K, Henn, F, Shea, S, Osten, P, Li, B