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Anthony Zador

Anthony Zador

Professor
The Alle Davis and Maxine Harrison Professor of Neurosciences

M.D., Ph.D., Yale University, 1994

zador@cshl.edu | 516-367-6950

Zador Lab Website   Faculty Profile

My lab studies how circuitry in the brain gives rise to complex behaviors, one of nature’s great mysteries. We study how the auditory cortex processes sound, and how this is interrupted in autism. We also seek to obtain a wiring diagram of the mouse brain at the resolution of individual neurons. Our unusual approach exploits cheap and rapid “next-gen” gene sequencing technology.

Anthony Zador and colleagues study how brain circuitry gives rise to complex behavior. Work in the lab is focused on two main areas. First, they ask how the cortex processes sound, how that processing is modulated by attention, and how it is disrupted in neuropsychiatric disorders such as autism. Recently, the lab found that when a rat makes a decision about a sound, the information needed to make the decision is passed to a particular subset of neurons in the auditory cortex whose axons project to a structure called the striatum. In the second major line of work in the Zador lab, they are developing new methods for determining the complete wiring instructions of the mouse brain at single-neuron resolution, which they term the “Connectome.” In contrast to previous methods, which make use of microscopy, these methods exploit high-throughput DNA sequencing. Because the costs of DNA sequencing are plummeting so rapidly, these methods have the potential to yield the complete wiring diagram of an entire brain for just thousands of dollars.

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All Publications

Cellular anatomy of the mouse primary motor cortex.

Oct 2021 | Nature | 598(7879):159-166
Muñoz-Castañeda, Rodrigo, Zingg, Brian, Matho, Katherine, Chen, Xiaoyin, Wang, Quanxin, Foster, Nicholas, Li, Anan, Narasimhan, Arun, Hirokawa, Karla, Huo, Bingxing, Bannerjee, Samik, Korobkova, Laura, Park, Chris, Park, Young-Gyun, Bienkowski, Michael, Chon, Uree, Wheeler, Diek, Li, Xiangning, Wang, Yun, Naeemi, Maitham, Xie, Peng, Liu, Lijuan, Kelly, Kathleen, An, Xu, Attili, Sarojini, Bowman, Ian, Bludova, Anastasiia, Cetin, Ali, Ding, Liya, Drewes, Rhonda, D'Orazi, Florence, Elowsky, Corey, Fischer, Stephan, Galbavy, William, Gao, Lei, Gillis, Jesse, Groblewski, Peter, Gou, Lin, Hahn, Joel, Hatfield, Joshua, Hintiryan, Houri, Huang, Junxiang, Kondo, Hideki, Kuang, Xiuli, Lesnar, Philip, Li, Xu, Li, Yaoyao, Lin, Mengkuan, Lo, Darrick, Mizrachi, Judith, Mok, Stephanie, Nicovich, Philip, Palaniswamy, Ramesh, Palmer, Jason, Qi, Xiaoli, Shen, Elise, Sun, Yu-Chi, Tao, Huizhong, Wakemen, Wayne, Wang, Yimin, Yao, Shenqin, Yuan, Jing, Zhan, Huiqing, Zhu, Muye, Ng, Lydia, Zhang, Li, Lim, Byung, Hawrylycz, Michael, Gong, Hui, Gee, James, Kim, Yongsoo, Chung, Kwanghun, Yang, X, Peng, Hanchuan, Luo, Qingming, Mitra, Partha, Zador, Anthony, Zeng, Hongkui, Ascoli, Giorgio, Josh Huang, Z, Osten, Pavel, Harris, Julie, Dong, Hong-Wei

Assessing the replicability of spatial gene expression using atlas data from the adult mouse brain.

19 Jul 2021 | PLoS Biology | 19(7):e3001341
Lu, Shaina, Ortiz, Cantin, Fürth, Daniel, Fischer, Stephan, Meletis, Konstantinos, Zador, Anthony, Gillis, Jesse

Standardized and reproducible measurement of decision-making in mice.

20 May 2021 | eLife | 10
International Brain Laboratory, Aguillon-Rodriguez, Valeria, Angelaki, Dora, Bayer, Hannah, Bonacchi, Niccolo, Carandini, Matteo, Cazettes, Fanny, Chapuis, Gaelle, Churchland, Anne, Dan, Yang, Dewitt, Eric, Faulkner, Mayo, Forrest, Hamish, Haetzel, Laura, Häusser, Michael, Hofer, Sonja, Hu, Fei, Khanal, Anup, Krasniak, Christopher, Laranjeira, Ines, Mainen, Zachary, Meijer, Guido, Miska, Nathaniel, Mrsic-Flogel, Thomas, Murakami, Masayoshi, Noel, Jean-Paul, Pan-Vazquez, Alejandro, Rossant, Cyrille, Sanders, Joshua, Socha, Karolina, Terry, Rebecca, Urai, Anne, Vergara, Hernando, Wells, Miles, Wilson, Christian, Witten, Ilana, Wool, Lauren, Zador, Anthony

Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections.

10 May 2021 | Nature Neuroscience
Sun, Yu-Chi, Chen, Xiaoyin, Fischer, Stephan, Lu, Shaina, Zhan, Huiqing, Gillis, Jesse, Zador, Anthony

BARcode DEmixing through Non-negative Spatial Regression (BarDensr).

Mar 2021 | PLoS Computational Biology | 17(3):e1008256
Chen, Shuonan, Loper, Jackson, Chen, Xiaoyin, Vaughan, Alex, Zador, Anthony, Paninski, Liam

Corticostriatal Plasticity Established by Initial Learning Persists after Behavioral Reversal.

Mar 2021 | eNeuro | 8(2):1-10
Ghosh, Sanchari, Zador, Anthony

BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.

23 Dec 2020 | Cell | 183(7):2040
Huang, Longwen, Kebschull, Justus, Fürth, Daniel, Musall, Simon, Kaufman, Matthew, Churchland, Anne, Zador, Anthony

Identification of a brainstem locus that inhibits tumor necrosis factor

24 Nov 2020 | Proceedings of the National Academy of Sciences of USA | 117(47):29803-29810
Kressel, A, Tsaava, T, Levine, Y, Chang, E, Addorisio, M, Chang, Q, Burbach, B, Carnevale, D, Lembo, G, Zador, A, Andersson, U, Pavlov, V, Chavan, S, Tracey, K

Replicability of spatial gene expression atlas data from the adult mouse brain

17 Oct 2020 | BioRxiv
Lu, Shaina, Ortiz, Cantin, Fürth, Daniel, Fischer, Stephan, Meletis, Konstantinos, Zador, Anthony, Gillis, Jesse

Cellular Anatomy of the Mouse Primary Motor Cortex

2 Oct 2020 | BioRxiv
Muñoz-Castañeda, Rodrigo, Zingg, Brian, Matho, Katherine, Wang, Quanxin, Chen, Xiaoyin, Foster, Nicholas, Narasimhan, Arun, Li, Anan, Hirokawa, Karla, Huo, Bingxing, Bannerjee, Samik, Korobkova, Laura, Park, Chris, Park, Young-Gyun, Bienkowski, Michael, Chon, Uree, Wheeler, Diek, Li, Xiangning, Wang, Yun, Kelly, Kathleen, An, Xu, Attili, Sarojini, Bowman, Ian, Bludova, Anastasiia, Cetin, Ali, Ding, Liya, Drewes, Rhonda, D’Orazi, Florence, Elowsky, Corey, Fischer, Stephan, Galbavy, William, Gao, Lei, Gillis, Jesse, Groblewski, Peter, Gou, Lin, Hahn, Joel, Hatfield, Joshua, Hintiryan, Houri, Huang, Jason, Kondo, Hideki, Kuang, Xiuli, Lesnar, Philip, Li, Xu, Li, Yaoyao, Lin, Mengkuan, Liu, Lijuan, Lo, Darrick, Mizrachi, Judith, Mok, Stephanie, Naeemi, Maitham, Nicovich, Philip, Palaniswamy, Ramesh, Palmer, Jason, Qi, Xiaoli, Shen, Elise, Sun, Yu-Chi, Tao, Huizhong, Wakemen, Wayne, Wang, Yimin, Xie, Peng, Yao, Shenqin, Yuan, Jin, Zhu, Muye, Ng, Lydia, Zhang, Li, Lim, Byung, Hawrylycz, Michael, Gong, Hui, Gee, James, Kim, Yongsoo, Peng, Hanchuan, Chuang, Kwanghun, Yang, William, Luo, Qingming, Mitra, Partha, Zador, Anthony, Zeng, Hongkui, Ascoli, Giorgio, Huang, Josh, Osten, Pavel, Harris, Julie, Dong, Hong-Wei

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