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Anthony Zador

Anthony Zador

Professor
The Alle Davis and Maxine Harrison Professor of Neurosciences

M.D., Ph.D., Yale University, 1994

zador@cshl.edu | (516) 367-6950

Zador Lab

My lab studies how circuitry in the brain gives rise to complex behaviors, one of nature’s great mysteries. We study how the auditory cortex processes sound, and how this is interrupted in autism. We also seek to obtain a wiring diagram of the mouse brain at the resolution of individual neurons. Our unusual approach exploits cheap and rapid “next-gen” gene sequencing technology.

Anthony Zador and colleagues study how brain circuitry gives rise to complex behavior. Work in the lab is focused on two main areas. First, they ask how the cortex processes sound, how that processing is modulated by attention, and how it is disrupted in neuropsychiatric disorders such as autism. Recently, the lab found that when a rat makes a decision about a sound, the information needed to make the decision is passed to a particular subset of neurons in the auditory cortex whose axons project to a structure called the striatum. In the second major line of work in the Zador lab, they are developing new methods for determining the complete wiring instructions of the mouse brain at single-neuron resolution, which they term the “Connectome.” In contrast to previous methods, which make use of microscopy, these methods exploit high-throughput DNA sequencing. Because the costs of DNA sequencing are plummeting so rapidly, these methods have the potential to yield the complete wiring diagram of an entire brain for just thousands of dollars.

    Watson School alumni spotlights

    Watson School alumni spotlights

    May 19, 2019

    This year, the Watson School of Biological Sciences celebrates the 20th anniversary of its first entering class of six Ph.D. candidates in September 1999. At CSHL, students are introduced to a broad and multi-disciplinary way to study biological sciences, and think critically to solve problems in their research. The school’s mission has remained the same...


    Watson School 2019 Ph.D.s

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    May 19, 2019

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    December 26, 2018

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    Dr. Zador wins Transformative Investigator award

    Dr. Zador wins Transformative Investigator award

    August 8, 2018

    Anthony Zador, a Cold Spring Harbor Laboratory (CSHL) professor and the Alle Davis and Maxine Harrison Endowed Chair of Neurosciences, has been named a Gill Symposium Transformative Investigator for his work on MAPseq. The prize honors researchers who have made exceptional contributions to cellular or molecular neuroscience. MAPseq (Multiplexed Analysis of Projections by Sequencing) is...


    Portrait of a Neuroscience Powerhouse

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    April 27, 2018

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    Revolutionary brain-mapping technique provides new blueprint for cortical connections

    Revolutionary brain-mapping technique provides new blueprint for cortical connections

    March 28, 2018

    Cold Spring Harbor, NY — Using a revolutionary new brain-mapping technology recently developed at Cold Spring Harbor Laboratory (CSHL), an international team of scientists led by Professor Anthony Zador have made a discovery that will force neuroscientists to rethink how areas of the cortex communicate with one another. The new technology, called MAPseq, allowed the...


    New leadership roles in BRAIN Initiative and International Brain Lab reflect CSHL’s excellence in neuroscience

    New leadership roles in BRAIN Initiative and International Brain Lab reflect CSHL’s excellence in neuroscience

    October 24, 2017

    Cold Spring Harbor, NY — The National Institute of Mental Health (NIMH) yesterday announced multiple grant awards totaling $50 million per year for five years to fund cutting-edge research on the brain. The project, part of the BRAIN Initiative Cell Census Network (BICCN) of the National Institutes of Health (NIH), establishes a Center and a...


    The brain atlas

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    December 14, 2016

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    Revolutionary method to map the brain at single-neuron resolution is successfully demonstrated

    Revolutionary method to map the brain at single-neuron resolution is successfully demonstrated

    August 19, 2016

    MAPseq uses RNA sequencing to rapidly and inexpensively find the diverse destinations of thousands of neurons in a single experiment in a single animal Cold Spring Harbor, NY — Neuroscientists today publish in Neuron details of a revolutionary new way of mapping the brain at the resolution of individual neurons, which they have successfully demonstrated...


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    If you thought all neuroscientists work with neurons, you’re wrong

    February 25, 2016

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Znamenskiy, P. and Zador, A. M. (2013) Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination. Nature, 497 pp. 482-485.

Zador, A. M. and Dubnau, J. and Oyibo, H. K. and Zhan, H. and Cao, G. and Peikon, I. D. (2012) Sequencing the Connectome. PLoS Biology, 10(10)

Jaramillo, E. S. and Zador, A. M. (2010) The auditory cortex mediates the perceptual effects of acoustic temporal expectation. Nat Neurosci, 14(2) pp. 246-51.

Otazu, G. H. and Tai, L. H. and Yang, Y. and Zador, A. M. (2009) Engaging in an auditory task suppresses responses in auditory cortex. Nature Neuroscience, 12(5) pp. 646 - 654 .

Wehr, M. and Zador, A. M. (2003) Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex. Nature, 426(6965) pp. 442-6.

Additional materials of the author at
CSHL Institutional Repository