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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

Scientists discover how a promising anti-leukemia drug harms cancer cells

5/14/2015

Inhibiting a protein called BRD4 critical to the survival of acute myeloid leukemia (AML) cells has shown to be an effective therapeutic strategy. Read the story »

Using CRISPR, biologists find a way to comprehensively identify anti-cancer drug targets

5/11/2015

Researchers use CRISPR to find binding pockets inside cancer cells, that when blocked, prevent the cells from proliferating and cause them to die. Read the story »

Scientists show the mammary gland ‘remembers’ prior pregnancy, spurring milk production

5/7/2015

Anecdotal reports of nursing mothers have long suggested that giving milk is a lot easier in second and subsequent pregnancies. Read the story »

New signaling pathway discovered in HER2-positive breast cancer, and two potentially powerful drug targets

4/20/2015

Rsearchers discovered a new pathway, which contains at least two potentially powerful drug targets Read the story »

Study revises standard theory of how PTEN, a critical tumor suppressor, shuts off growth signals

4/9/2015

Scientists discover new evidence explaining precisely how the protein encoded by PTEN (called PTEN) works Read the story »

Tumor cells that mimic blood vessels could help breast cancer spread to other sites

4/8/2015

“Vascular mimicry” observed in mice could be helping tumors evade anti-angiogenesis drugs Read the story »

Scientists discover important communication mechanism between two brain areas implicated in schizophrenia

4/7/2015

Researchers discover an inhibitory connection between certain brain areas that can control the timing of information flow to the prefrontal cortex Read the story »

When thinking about numbers, people estimate a range rather than a single value

3/30/2015

Representing numbers as a range of possible values allows people to utilize multiple streams of information, leading to improved decisions Read the story »

A new brain circuit that controls fear is identified

1/19/2015

Researchers discover a pathway in that mouse brain that regulates fear memory and behavior Read the story »

3D culture system for pancreatic cancer has potential to change therapeutic approaches

1/15/2015

Organoid technology with human tissue provides a model for full progression of the disease Read the story »

A novel biomarker for mutant p53 could help pathologists assessing tumors during surgery

1/5/2015

New discovery may make it easy for cancer surgeons to determine if a patient has a potentially lethal mutation. Read the story »

New study casts sharpest light yet on genetic mysteries of autism

10/29/2014

Our picture of how genetic errors contribute to autism has just gotten sharper. Read the story »

How a molecular Superman protects the genome from damage

10/16/2014

Scientists find a new role for RNAi protein Dicer in preventing collisions during DNA replication. Read the story »

Gambling with confidence: Are you sure about that?

9/18/2014

Scientists uncover the neural basis of confidence in the rat brain Read the story »

New understanding of a mechanism by which cells try to arrest oncogene action

8/28/2014

What happens inside cells when they detect the activation of a cancer-inducing gene? Read the story »

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