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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells

11/3/2012

Researchers find method to target the cancer cell's metabolic process to destroy it. Read the story »

Neuroscientists propose a revolutionary DNA-based approach to map wiring of the whole brain

10/22/2012

Research propose a new and potentially revolutionary way of obtaining a neuronal connectivity map of the whole mouse brain. Read the story »

Biologists characterize enzymatic identity of key player in generating genome-protecting piRNAs

10/11/2012

Scientists work to understand the earliest steps in a process that protects animal genomes from potentially dangerous genetic elements Read the story »

Scientists reverse Alzheimer’s-like memory loss in animal models by blocking EGFR signaling

9/24/2012

EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss Read the story »

Research identifies protein that regulates key ‘fate’ decision in cortical progenitor cells

9/20/2012

DOCK7 expression determines if radial glial cells will proliferate or differentiate Read the story »

In massive genome analysis ENCODE data suggests ‘gene’ redefinition

8/31/2012

Potentially far-ranging implications for complex disease. Read the story »

An error-eliminating fix overcomes big problem in ‘3rd-gen’ genome sequencing

6/29/2012

The next “next-gen” technology in genome sequencing has gotten a major boost. Read the story »

‘Most comprehensive’ genetic analysis of maize plant will help raise yields, expand its range

6/1/2012

An international research team involving 17 institutions has published the most comprehensive analysis to date of the maize genome. Read the story »

CSHL researchers solve structure of human protein critical for silencing genes

5/25/2012

Scientists solve the three-dimensional atomic structure of the human Argonaute protein--a key player in the phenomenon known as RNA interference. Read the story »

Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers

5/7/2012

Such deletions could confer survival advantage on tumors, a challenge to ‘2-hit theory’ of tumor suppressor action. Read the story »

A striking link is found between the Fragile-X gene and mutations that cause autism

4/25/2012

Scientists found a striking association between genes disrupted in children with autism and genes that are targets of FMRP Read the story »

Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment

4/16/2012

Researchers use “live” microscopy to observe how treatments affect cancer cells in mouse tumors. Read the story »

Study shows rats match humans in decision-making that involves combining different sensory cues

3/13/2012

The next time you set a trap for that rat running around in your basement, here’s something to consider. Read the story »

CSHL team introduces automated imaging to greatly speed whole-brain mapping efforts

1/12/2012

New technology from Osten lab should greatly facilitate systematic study of mouse models of human brain disorders such as schizophrenia and autism. Read the story »

Study uncovers a molecular “maturation clock” that modulates branching architecture in tomato plants

12/22/2011

The secret to pushing tomato plants to produce more fruit might not lie in an extra dose of Miracle-Gro Read the story »

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