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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

In massive genome analysis ENCODE data suggests ‘gene’ redefinition

8/31/2012

Potentially far-ranging implications for complex disease. Read the story »

An error-eliminating fix overcomes big problem in ‘3rd-gen’ genome sequencing

6/29/2012

The next “next-gen” technology in genome sequencing has gotten a major boost. Read the story »

‘Most comprehensive’ genetic analysis of maize plant will help raise yields, expand its range

6/1/2012

An international research team involving 17 institutions has published the most comprehensive analysis to date of the maize genome. Read the story »

CSHL researchers solve structure of human protein critical for silencing genes

5/25/2012

Scientists solve the three-dimensional atomic structure of the human Argonaute protein--a key player in the phenomenon known as RNA interference. Read the story »

Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers

5/7/2012

Such deletions could confer survival advantage on tumors, a challenge to ‘2-hit theory’ of tumor suppressor action. Read the story »

A striking link is found between the Fragile-X gene and mutations that cause autism

4/25/2012

Scientists found a striking association between genes disrupted in children with autism and genes that are targets of FMRP Read the story »

Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment

4/16/2012

Researchers use “live” microscopy to observe how treatments affect cancer cells in mouse tumors. Read the story »

Study shows rats match humans in decision-making that involves combining different sensory cues

3/13/2012

The next time you set a trap for that rat running around in your basement, here’s something to consider. Read the story »

CSHL team introduces automated imaging to greatly speed whole-brain mapping efforts

1/12/2012

New technology from Osten lab should greatly facilitate systematic study of mouse models of human brain disorders such as schizophrenia and autism. Read the story »

Study uncovers a molecular “maturation clock” that modulates branching architecture in tomato plants

12/22/2011

The secret to pushing tomato plants to produce more fruit might not lie in an extra dose of Miracle-Gro Read the story »

First comprehensive DNA study of mast cell leukemia uncovers clues that could improve therapy

12/16/2011

Sequencing a cancer patient’s “exome” reveals mutations critical for improving diagnostic power and targeted therapy. Read the story »

Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding

12/13/2011

Hydrogen sulfide plays an important role in the regulation of a signaling pathway implicated in biological malfunctions linked to Alzheimer’s. Read the story »

CSHL team solves a protein complex’s molecular structure to explain its role in gene silencing

11/14/2011

Researchers discover new details of how the RNA-Induced Initiation of Transcriptional gene Silencing (RITS) complex contributes to gene silencing Read the story »

Study reveals details of alternative splicing circuitry that promotes cancer’s Warburg effect

11/2/2011

Dr. Krainer and his team discovered details of the molecular events that trigger the production of the enzyme that drives the Warburg effect. Read the story »

Study reveals new role for RNA interference during chromosomal replication

10/17/2011

A new study in Nature by CSHL Professor Rob Martienssen and his group describes a new role for RNAi during chromosomal replication, one that allows th Read the story »

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