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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

Study shows how “bookmarking” genes before cell division accelerates their subsequent reactivation

10/11/2011

Researchers discover how "bookmarking" a gene pre-split accelerates its reactivation after the division. Read the story »

CSHL team finds evidence for the genetic basis of autism

10/3/2011

Scientists find evidence that inheriting fewer copies of these genes leads to features resembling those used to diagnose children with autism. Read the story »

Nicholas Tonks Chasm of Doom active site

Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity

9/29/2011

Novel drugs find ways around obstacles of the pathway within cells that regulates the response to insulin. Read the story »

Relationship between two mutated genes can dictate prostate cancer outcome, aid treatment decisions

8/15/2011

Research have discovered a way to distinguish between two types of prostate cancer. Read the story »

Unconventional hunt for new cancer targets leads to a powerful drug candidate for leukemia

8/3/2011

Researchers find an unconventional RNAi-based approach to pinpoint a new therapeutic target and drug candidate for acute myeloid leukemia (AML). Read the story »

Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge

8/1/2011

What can an immobile corn plant do to escape encroaching shade? Activate genes to change its shape, research reveals. Read the story »

CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit

6/16/2011

Researchers create detailed blueprint of the allosteric site where phenylethanolamines bind to the receptor for future neurological treatments Read the story »

Autism study validates importance of spontaneous causal mutations and sheds new light on gender skew

6/8/2011

A clinically extensive study of 1000 families with one autistic child and one unaffected sibling has validated a controversial theory. Read the story »

Study identifies stem cell-related changes that may contribute to age-related cognitive decline

5/5/2011

Age-related drop in new neurons may be due to “single use” or “disposable” nature of adult stem cells in the brain. Read the story »

Researchers identify therapeutic target for liver cancer and a predictive biomarker of response

3/14/2011

The research points to a clear strategy for identifying the subset of liver cancer patients who might benefit from treatment with a therapeutic monocl Read the story »

With new method, CSHL team is able to infer how tumors evolve and spread

3/11/2011

Researchers find that cancerous tumors evolve in short, sudden bursts, rather than gradually. Read the story »

Neuroscientists find overlooked brain area is an important locus of depression

2/24/2011

The lateral habenula is hyperactive in rat models of human depression Read the story »

New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered

8/18/2010

Researchers uncover how tumor cells can develop resistance to targeted therapies. Read the story »

Researchers discover that one type of stem cell creates a niche for another type within bone marrow

8/12/2010

Understanding how blood stem cells are maintained within the niche offers new opportunities to exploit them therapeutically. Read the story »

CSHL researchers demonstrate efficacy of antisense therapy for spinal muscular atrophy

7/12/2010

Researchers look into the use of chemically-modified pieces of RNA called antisense oligonucleotides to treat SMA. Read the story »

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