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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

A shift in the code: New method reveals hidden genetic landscape

8/18/2014

Scientists develop algorithm to uncover genomic insertions and deletions involved in autism, OCD Read the story »

Research may explain how the body’s foremost anti-cancer ‘guardian’ protein learned to switch sides

7/29/2014

Researchers have discovered a new function of the body’s most important tumor-suppressing protein. Read the story »

In development, it’s all about the timing

7/17/2014

Closely related organisms share most of their genes, but these similarities belie major differences in behavior, intelligence, and physical appearance Read the story »

Neuroscientists explain how mutated X-linked mental retardation protein impairs neuronal function

6/24/2014

There are new clues about malfunctions in brain cells that contribute to intellectual disability and possibly other developmental brain disorders. Read the story »

GluN1a/GluN2B NMDA receptors calcium-binding

Unprecedented detail of intact neuronal receptor offers blueprint for drug developers

5/29/2014

NMDA receptor malfunction is implicated in Alzheimer’s, Parkinson’s, depression, schizophrenia, autism, and stroke Read the story »

Dealing with stress—to cope or to quit?

5/27/2014

Researchers identify neurons that determine whether an individual will be depressed or resilient Read the story »

Team reports validation of potentially powerful new way to treat HER2-positive breast cancer

5/21/2014

Researchers report a discovery that they hope will lead to the development of a powerful new way of treating an aggressive form of breast cancer. Read the story »

Unravelling a mystery in the ‘histone code’ shows how gene activity is inherited

3/13/2014

Why is histone H3.3 associated with active genes, but histone H3.1 is not? Read the story »

Researchers propose new way to make sense of ‘Big Data’

2/15/2014

New application of a classic concept challenges the latest statistical tools. Read the story »

Scientists discover how leukemia cells exploit ‘enhancer’ DNA elements to cause lethal disease

11/27/2013

Discovery reveals how a drug, now in multiple human trials, halts production of Myc protein and stops progression of AML. Read the story »

CSHL neuroscientists identify class of cortical inhibitory neurons that specialize in disinhibition

10/6/2013

An inhibitory neuron type is found to specifically suppress the activation of other inhibitory neurons in cerebral cortex. Read the story »

Study provides big-picture view of how cancer cells are supported by normal cells in and near tumors

9/19/2013

Study highlights therapeutic importance of targeting a broad set of signals between cancer cells and normal cells that support them. Read the story »

First animal model of adult-onset SMA sheds light on disease progression and treatment

9/9/2013

Another proof of principle for TSUNAMI method in modeling spinal muscular atrophy and other splicing-related illnesses Read the story »

Key step in molecular dance that duplicates DNA is deciphered

7/14/2013

Scientists identify new details of biochemical interactions necessary for cell division Read the story »

Cancer research brief: Targeting pancreatic cancer drug resistance

7/8/2013

Knocking down cancer cell survival signals increases the effectiveness of chemotherapy Read the story »

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