Cancer	Neuroscience	Plant Biology	Quantitative Biology	Bioinformatics & Genomics
Researchers at CSHL are devoted to understanding the fundamental biology of human cancer and the development of new diagnostics and therapeutics for specific cancer types. Topics of interest include cancer genetics, tumor biology, mouse models for human cancer, chromosome dynamics, epigenetics, gene expression, DNA replication and cell signaling. CSHL neuroscientists focus on understanding how neural activity and neural circuitry underlie behavior as well as how disruptions in these circuits lead to dysfunction and neurological disorders such as Alzheimer’s disease, autism, schizophrenia and depression. Plant Biologists at CSHL focus on plant development and gene expression, using Arabidopsis, maize and tomato as model systems. In addition to leading to a better understanding of these basic processes, this research also works to improve agricultural yield and biofuel production. CSHL scientists apply their expertise in applied mathematics, statistics, physics, engineering and computer science to approach challenging biological questions. Areas of research include population genetics, signal and imaging processing, evolutionary biology and genomic analysis. Much of the research at CSHL involves genetic and genomic information and approaches. CSHL scientists are developing new technologies to sequence, analyze and annotate genomes, as well as new tools to study and manipulate gene expression to better understand basic biological mechanisms, cancer and neurological disorders.

Cold Spring Harbor Laboratory is a world-renowned, private research and education institution with research programs in Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Bioinformatics & Genomics. The research environment is highly collaborative, allowing CSHL scientists to work together across disciplines to solve biology’s most challenging problems. The ultimate goal is to apply this research on basic biological mechanisms to improve the diagnosis and treatment of cancer, neurological disorders and other diseases.

Research at the Laboratory is enriched by collaborations with scientists at other universities, hospitals, and in the biotech and pharmaceutical sectors. In addition, the Meeting and Courses program attracts over 12,000 scientists from around the world each year to the Laboratory, providing additional opportunities for scientific interactions and the exchange and development of new ideas.

The innovative spirit, vision, and talent of the Laboratory’s scientists continue to place CSHL among the top 1% of life science institutions most cited in published research. The dynamic, collaborative environment at CSHL also fosters a superb educational experience for an outstanding group graduate students and postdoctoral researchers.