CSHL celebrates 20 years of graduate school at 2019 commencement
Institutional | News
The Watson School of Biological Sciences held its 16th commencement, with seven researchers graduating with doctoral degrees.
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CSHL Stories
Leading discovery
Institutional | Feature
Current discoveries about DNA and human genome position CSHL scientists to make life-changing breakthroughs that will improve the human condition.
Honorary degrees to former CSHL leaders
Education | News
From pioneering eukaryotic gene regulation to directing cancer research, here are the alumni being awarded honorary Doctor of Science degrees.
Watson School alumni spotlights
Education | News
This year, Watson School celebrates the 20th anniversary of its first entering class and looks back at some notable alumni from over the years.
Watson School 2019 Ph.D.s
Education | News
Seven students were awarded Ph.D. degrees from Watson School this May. Here, they reflect on their time at the Laboratory as they look to the future.
An essay from the President: Biology for the planet
Research | Feature
CSHL plant scientists are looking for solutions to the biggest questions in agriculture as environments are reshaped by climate change.
Enzyme PHLPP2 could be a viable drug target for treating prostate cancer
Research | News
Researchers have identified an enzyme called Phlpp2 as an attractive drug target for treating prostate cancer.
Remembering John Cairns, CSHL Director, 1963-1968
Institutional | News
CSHL celebrates the achievements of the late Dr. John Cairns, lab director from 1963 to 1968.
Profile: Doreen Ware champions the plant genome
Research | Feature
Molecular biologist Doreen Ware uses computer science to parse out the genetic roadmaps of plants.
Cryptic mutation is cautionary tale for crop gene editing
Research | Feature
Unexpected interactions between mutations can be a thorn in the side for plant breeders. Scientists unveil what drove one infamous “cryptic” mutation.
Andrea Schorn zooms in on small RNAs in the cell
Research | News
Dr. Andrea Schorn joins CSHL faculty as research assistant professor. Her focus is exploring transposable elements in the genome of mammalian cells.
DNA and pop culture quiz
Quiz
When artistic expression meets gene expression, how well does art imitate life? Take our five-question science IQ quiz to find out.
Cold Spring Harbor Laboratory announces exclusive license with plant breeding start-up Inari
Research | News
CSHL announced a licensing agreement with partner Inari, a company that is advancing plant breeding by tapping nature’s genetic diversity.
Rob Martienssen wins Martin Gibbs Medal for plant research
Institutional | News
CSHL Professor Rob Martienssen wins the 2019 Martin Gibbs Medal for his contributions to plant biology.
To protect stem cells, plants have diverse genetic backup plans
Research | News
Experts discover how an essential genetic circuit found in all flowering plants, regardless of species, is protected in startlingly different ways.
NIH grant awarded for interneuron research
Institutional | News
CSHL postdoc Maggie Crow will use her NIH grant to pursue the quantification and analysis of specific types of neurons in the brain.
President Bruce Stillman wins prestigious Gairdner Award
Institutional | News
Dr. Bruce Stillman, President & CEO of CSHL, has been awarded the 2019 Canada Gairdner International Award for his work on eukaryotic DNA replication.
Crop yield in maize influenced by unexpected gene ‘moonlighting’
Research | News
Yield of the maize plant is tied to activity of a gene called RAMOSA3, but new evidence suggests the gene performs other unexpected functions
Hannah Meyer joins CSHL Quantitative Biology faculty
Institutional | News
Hannah Meyer is the newest Quantitative Biology Fellow at CSHL, studying how our immune system learns to identify and fight pathogens.
CSHL President elected as AACR Academy Fellow
Institutional | News
CSHL President and CEO Dr. Bruce Stillman has been elected to the AACR Academy as part of the 2019 Fellows class.
One experiment: Observing cancer’s progress in a mouse prostate
Research | Feature
Using a technique originally designed for mapping brains, two CSHL labs have worked together to image cancer progression in a mouse prostate.
Banbury meeting addresses neurotechnology concerns
Institutional | News
A white paper written after an important Banbury Center meeting discusses the lack of oversight in direct-to-consumer neurotechnologies.
New cell subtypes classified in mouse brain
Research | News
To map a brain, an intuitive system for classifying neuron types is necessary. Now, a promising approach reveals new cell subtypes in the mouse brain.
Adrian Krainer wins RNA Society’s Lifetime Achievement Award
Institutional | News
Professor Adrian Krainer was awarded the RNA Society’s Lifetime Achievement Award for his life-saving research.
Congressman Suozzi congratulates CSHL Partner for the Future
Education | News
Partner for the Future Pragati Muthukumar received a special commendation from Congressman Tom Suozzi.
Genetic ‘usual suspects’ identified in researchers’ new list
Research | News
An exhaustive ranked list of “usual suspect” genes involved in disease may prove invaluable for future research and drug discovery.
Chandelier neuron requires ‘Velcro-like’ molecule to form connections
Research | News
How do brain cells network? Researchers have discovered an essential ingredient that facilitates one type of neuron’s many neighborly connections.
Detailed new primate brain atlas could lead to disease insights
Research | News
An international effort has mapped the marmoset brain at an unprecedented level of detail, which brings us closer to understanding the human brain.
David McCandlish named Sloan Research Fellow
Institutional | News
Assistant Professor David McCandlish has been named a 2019 Sloan Research Fellow for his promising work in the field of quantitative biology.
bioRxiv surpasses one million monthly downloads
Institutional | News
A recent study illustrates the success of bioRxiv, CSHL’s biology preprint server.
Christina Renna Foundation gives $35k for pediatric cancer research
Institutional | News
The Christina Renna Foundation donated $35,000 to CSHL for continued work on Sarcoma Research Project and research into RMS.
CSHL Scientific Advisory Council member wins Vilcek Prize
Institutional | News
Dr. Angelika Amon, a member of the CSHL Scientific Advisory Council, wins the Vilcek Foundation Prize for her important work in cell biology.
How does math help us understand the brain?
Research | Feature
An exploration of how computational neuroscientist Tatiana Engel uses math to understand how the brain makes decisions.
CSHL Fellow Jason Sheltzer wins innovation award
Institutional | News
CSHL Fellow Jason Sheltzer wins the Damon Runyon-Rachleff Innovation Award for his work on cancer.
CSHL Scientific Advisory Council member wins NAS honor
Institutional | News
Dr. Eve Marder of the CSHL Scientific Advisory Council wins the National Academy of Sciences Award in the Neurosciences.
CSHL donates sheets to veterans in need
Institutional | News
CSHL donated 75 bags of sheets to the United Veterans Beacon House, with the aid of the Lindenhurst Rotary Club and the Christina Renna Foundation.
Targeting ‘hidden pocket’ for treatment of stroke and seizure
Research | News
Researchers have identified a hidden molecular “pocket” in a special neuron receptor, which could lead to better treatments for stroke and seizures.
Austin’s Purpose donates $10k to neuroscience research
Institutional | News
Epilepsy research-supporting organization Austin’s Purpose makes a donation to continue key neuroscience research in Professor Hiro Furukawa’s lab.
Statement by Cold Spring Harbor Laboratory addressing remarks by Dr. James D. Watson in “American Masters: Decoding Watson”
Institutional | News
Statement by Cold Spring Harbor Laboratory addressing remarks by Dr. James D. Watson in “American Masters: Decoding Watson.”
The year of CRISPR
Research | Feature
A look at the various labs across CSHL that utilize CRISPR in their research, and the groundbreaking discoveries they help uncover.
How much are we learning? Natural selection is science’s best critic
Research | News
Researchers determine that natural selection and our evolutionary history may be the best guides for future research.
Taking uncertainty out of cancer prognosis
Research | News
CSHL Fellow Jason Sheltzer has analyzed nearly 20,000 cancer patient histories and genetic data to take the guesswork out of prognosis.
National Academy of Inventors Fellow, Adrian Krainer
Institutional | News
Professor Adrian Krainer has been named a NAI 2018 Fellow for his work on the first FDA-approved treatment for spinal muscular atrophy.
Big bold dreamers
Institutional | Feature
Dreamers drive discoveries. CSHL honors its many scientists making big impacts in their respective fields.
Marilyn Simons elected Cold Spring Harbor Laboratory chair
Institutional | News
Dr. Marilyn Simons becomes the chair of the CSHL Board of Trustees, new officers are elected, and three new trustees join the board.
Breakthrough Prize laureates meet at CSHL
Institutional | News
Breakthrough Prize winner Adrian Krainer & C. Frank Bennett reunite for the first time since their award ceremony at CSHL to discuss further project.
Molly Hammell wins CZI award for ALS study
Institutional | News
Associate Professor Molly Hammell wins award for proposed study to find transposable elements that are implicated in ALS.
How the brain hears and fears
Research | News
Researchers are studying how the brain reacts to sounds that it associates with fear, and how easy it is for the brain to learn and unlearn.
Inconspicuous protein key to deadly blood cancer
Research | News
Associate Professor Chris Vakoc and his team find that an aggressive type of leukemia is heavily-dependent on a common protein.
AAAS names two CSHL faculty as 2018 Fellows
Institutional | News
David Jackson and Jan A. Witkowski were both named 2018 AAAS Fellows for their work in the fields of agriculture and biology.
Pancreatic cancer’s addiction could be its end
Research | News
Researchers may have found a link between improper protein production and the spread of pancreatic cancer.
13th Double Helix Medals dinner raises over $4 million
Institutional | News
Dr. Priscilla Chan, Mark Zuckerberg, and Dr. Larry Norton were honored for their contributions to basic research at the Double Helix Medals dinner.
A great place to work!
Institutional | News
CSHL is named a 2018 Top Long Island Workplace by Newsday through the use of employee surveys.
From many mice, unexpected genius
Research | News
Researchers find that some individual mice are smarter than their fellow rodents, which can provide insights into decision-making.
Thanks, National Grid Foundation for hands-on science!
Education | News
The DNA Learning Center has completed the National Grid Advanced Genetics Program (NGAGP) in the Central Islip school district.
Turning cells against pancreatic cancer
Research | News
Researchers have found a way to turn cancer-supporting cells into cells that restrict the cancerous growth in the pancreas.
New regulators of nitrogen use in plants identified
Research | News
A team of CSHL plant biologists identify gene regulators that may help plants utilize nitrogen better and prevent excess nitrogen in soil.
The big problem of small data: A new approach
Research | News
You’ve heard of “big data” but what about small? Researches have crafted a modern approach that could solve a decades-old problem in statistics.
Breakthrough Prize to CSHL professor for SMA research
Research | News
Professor Adrian Krainer has received a Breakthrough Prize in Life Sciences for his work on the first FDA-approved treatment of SMA.
Cancer research from a different perspective
Research | News
CSHL Assistant Professor Tobias Janowitz discusses his patient-centric approach to studying cancer
What’s that smell? Neuroscientists are figuring it out
Research | News
Neuroscientists Florin Albeanu and Alexei Koulakov win the NIH Director’s Transformative Research Award for their project on the olfactory system
CRISPR could bring groundcherries to market
Research | News
CSHL Professor Zachary Lippman uses CRISPR to make the groundcherry more suitable for large-scale farming
Computational neuroscientist wins BRAIN grant
Institutional | News
Assistant Professor Tatiana Engel earns grant to build tools that will help build better models of the brain
CSHL podcast wins prestigious PR News award
Institutional | News
CSHL’s Base Pairs podcast wins the Platinum PR Award for Best Podcast from PR News
How a sleeping cancer awakens and metastasizes
Research | News
Chronic inflammation can reawaken dormant cancer cells and spur metastasis. It may be preventable
Future scientists take to the bench
Education | News
The latest class of the Partners for the Future program visit the Lab and meet their mentors as they get to work
Genomes, justice, and the journey here
Research | Feature
CSHL Professor W. Richard McCombie discusses genomic privacy and sequencing technology in this episode of Base Pairs.
Path to cancer in the brain set by protein CHD5
Research | News
Researchers find that protein keeps neural stem cells from activating too soon and hindering brain development
Predicting how splicing errors impact disease risk
Research | News
New research helps correlate genetic mutations with errors in RNA splicing that can cause serious illness
CSHL team wins scientific case competition
Institutional | News
Five CSHL postdocs and graduate students won first place at the fifth annual Tufts New England Case Competition (TUNECC).
CSHL helps ring opening bell at Nasdaq
Institutional | News
CSHL Professor Adrian Krainer and his team join the Spinal Muscular Atrophy (SMA) Foundation in ringing the Nasdaq opening bell
Undergrad symposium highlights lessons in the lab
Education Research | News
The 2018 Undergraduate Research Program class presents their projects after working for ten weeks in various labs across campus.
The miracle of brain development
Research | Feature
In a series of 8 stunning images, CSHL scientists enable us to share the miracle of a brain as it self-assembles
One experiment: Building a brain
Research | Feature
A genetic program precisely guides development of a part of the brain
Dr. Zador wins Transformative Investigator award
Institutional | News
CSHL professor Anthony Zador wins Gill Symposium prize for his innovative work on MAPseq
Seeding citizen science with DNA barcoding
Education | News
Teachers trained in DNA barcoding can mentor students as they become citizen scientists investigating what interests them most
Big plans for a tiny plant
Research | Feature
On this episode of Base Pairs, Rob Martienssen discusses how duckweed could be the next biofuel and help combat climate change
Massive genome havoc in breast cancer is revealed
Research | News
Researchers have made a highly detailed map of 20,000 structural variations in a cancer cell’s genome
CSHL Fellow Semir Beyaz wins three awards
Institutional | News
Semir Beyaz has won three awards for his research on the impact of dietary choices on the body’s immunity against cancer
Nicholas Tonks wins prestigious ASBMB award
Institutional | News
Professor Nicholas Tonks wins Earl and Thressa Stadtman Distinguished Scientist Award from the American Society for Biochemistry and Molecular Biology
CSHL spinoff wins investment prize
Research | News
CSHL spinoff company MapNeuro Inc., which uses tech developed in Zador lab, wins 2018 Seed Capital Prize from Alexandria LaunchLabs
Progress toward improved Wilson’s disease drug
Research | News
Encouraging early results in a potential new treatment for Wilson's disease
Researchers discover new type of lung cancer
Research | News
Researchers have discovered a new form of lung cancer.
Postdoc wins Indian National Science Academy prize
Institutional | News
Dhananjay Huilgol, a postdoc in Professor Joshua Huang’s lab, wins one of India’s highest honors for young investigators
The case for open and inclusive science
Institutional | Feature
America must continue to a place where the most talented people in the world want to live, study and work
Nation’s cancer centers endorse HPV vaccination
Research | News
Dr. Stillman and Dr. Tuveson joined with the leaders of other institutions nationwide in endorsing a statement regarding the HPV vaccine
Alexander Dobin dives into genomic data
Research | News
Alexander Dobin joins the faculty as its newest assistant professor, working on the computational side of genomics research
Suffrage Science award to Mikala Egeblad
Institutional | News
Egeblad and 10 other female scientists from around the world were presented with heirloom jewelry at the Suffrage Science awards ceremony
A better way to trace neuronal pathways
Research | News
Researchers have improved a key method used to map circuits in the brain
Microbial masterpieces win ASM Agar Art Contest
Education | News
Science-inspired artworks created at CSHL’s DNA Learning Center win in the 2018 American Society for Microbiology Agar Art Contest
Organoid profiling personalizes treatments for pancreatic cancer
Research | News
Pancreatic organoids grown from patients' tumors make precision medicine possible
Prof. Zachary Lippman named Blavatnik Award finalist
Institutional | News
Professor Zachary Lippman was chosen as a Finalist in Life Sciences for the 2018 Blavatnik National Awards
Scientists show how brain circuit generates anxiety
Research | News
Researchers have identified a circuit in the brain that drives anxiety
CSHL’s Zachary Lippman named HHMI Investigator
Institutional | News
CSHL Professor Zach Lippman is selected as an HHMI investigator, in recognition of his innovative work in the field of plant genetics
Pershing Square Sohn prize to Camila dos Santos
Institutional | News
Assistant Professor Camila dos Santos, Ph.D., has been awarded the Pershing Square Sohn Prize for Young Investigators in Cancer Research.
How pancreatic cancer spreads after surgery
Research | News
Researchers have solved a mystery about how pancreatic cancer spreads
The immune system, unleashed
Research | Feature
Cancer immunotherapy has a long and storied history, one that begins with a young woman suffering from a pain in her hand
High schoolers reveal fraudulent herbal medicines
Education | News
Some herbal products are not what they claim to be. These high school students and their mentor used DNA to investigate
Nature’s masterpiece: the brain
Institutional | Feature
A message from President and CEO Dr. Bruce Stillman from the Spring 2018 Harbor Transcript on the innovative research happening at CSHL
How key brain receptor works in hostile conditions
Research | News
A structural variation enables a key brain receptor to function in a hostile environment
Bringing immune cells back into the cancer fight
Research | Feature
Doug Fearon used a mouse model to discover how pancreatic cancer hides from the immune system
Cold Spring Harbor Laboratory celebrates its 15th commencement
Education | News
Five students from the Watson School of Biological Sciences graduate, with special keynote speeches from Drs. David and Leon Botstein
Therapeutic RNA corrects splicing defect that causes familial dysautonomia
Research | News
A team provides proof of concept for an RNA drug correcting an error in RNA splicing that causes familial dysautonomia (FD)
Portrait of a Neuroscience Powerhouse
Research | Feature
A relatively small neuroscience group at CSHL is having an outsized impact on a dynamic and highly competitive field
Watson School 2018 Ph.D.s
Education | News
CSHL celebrates its 15th commencement, with five promising Ph.D. students graduating and honorary degrees presented to David and Leon Botstein
David Tuveson elected to the AACR Board of Directors
Institutional Research | News
CSHL Professor David Tuveson was elected to the Board of Directors of the American Association for Cancer Research for the 2018 - 2021 term
Newly identified genetic mutation results in intellectual disability and developmental delay
Research | News
Scientists have identified a new illness caused by a genetic mutation that gives rise to a wide range of symptoms including intellectual disability
CSHL’s Base Pairs is a finalist for the 2018 Webby Awards
Institutional | News
CSHL's podcast Base Pairs was nominated for a prestigious Webby award for best Science and Education podcast
Andrew Whiteley appointed VP of Business Development and Technology Transfer at CSHL
Institutional | News
Life science business leader Andrew Whiteley becomes the Vice President of CSHL's Business Development and Technology Transfer department.
Study reveals a way to make prostate cancer cells run out of energy and die
Research | News
In lethal prostate cancer, the gene PTEN is often missing. In such cases, one effective treatment may be to administer drugs that inhibit mitochondria
Research profile: Robert Maki
Research | Feature
Straddling CSHL and Northwell Health gives Dr. Maki the perspective he needs to bring cancer research closer to the practice of treating patients
The course to science stardom
Education | Feature
At least 10 CSHL Courses alumni have gone on to win a Nobel Prize, while others have become leaders of major scientific institutions
Revolutionary brain-mapping technique provides new blueprint for cortical connections
Research | News
Researchers used MAPseq, a revolutionary brain mapping method, to make a discovery that will force neuroscientists to rethink how areas of the cortex
Evans Foundation MDS Young Investigator Award to Lingbo Zhang
Research | News
CSHL Fellow Lingbo Zhang received a Young Investigator Award from the Edward P. Evans Foundation
One experiment: Twice the tomatoes
Research | Feature
Zachary Lippman’s team found a way to boost tomato yield by digging into the plant’s genome and fine-tuning its branching patterns.
Unique communication strategy discovered in pathway controlling plant growth
Research | News
Scientists have identified a receptor on plant stem cells that can issue different instructions about how the plant will grow.
The cancer answer that wasn’t
Research | Feature
We look at the "reproducibility crisis" in science, with a cancer researcher discovering something he didn't expect while experimenting with MELK
Ratner and Weisbrod join Cold Spring Harbor Laboratory Board of Trustees
Institutional | News
Bruce Ratner and Stuart Weisbrod were elected to the Cold Spring Harbor Laboratory Board of Trustees
CRISPR-based system identifies important new drug targets in a deadly leukemia
Research | News
CRISPR was used to find 2 new druggable targets in a deadly leukemia
New method identifies splicing biomarkers for liver cancer
Research | News
Researchers have developed a method for identifying splicing-based biomarkers for liver cancer
New CSHL Fellow studies nexus of diet, metabolism, and cancer
Research | News
CSHL Fellow Semir Beyaz works on the effects of what we eat and how it affect the incidence of colorectal cancers.
One experiment: When cancer is hiding in plain sight
Research | Feature
Douglas Fearon's team is figuring out how to get immune cells to recognize—and kill—pancreatic cancer cells
The secret to tripling the number of grains in sorghum and perhaps other staple crops
Research | News
A simple genetic modification can triple grain production in sorghum, a drought-tolerant plant that is an important source of food and animal feed.
Science self-corrects: cancer gene does not pass reproducibility test
Research | News
CSHL Fellow Jason Sheltzer and his research team use CRISPR to discover that MELK is not actually involved in cancer.
Autism genetics study calls attention to impaired motor skills, general cognitive impairment
Research | News
New research on the genetic causes of autism calls attention to diminished motor skills and suggests the importance of broad cognitive impairment
PLOS and CSHL enter agreement to enable preprint posting on bioRxiv
Institutional | News
The Public Library of Science (PLOS) will now be automatically posting papers submitted to its journal on bioRxiv, CSHL's preprint server
Dr. Leemor Joshua-Tor honored with Mildred Cohn Award from ASBMB
Institutional | News
Professor Leemor Joshua-Tor receives the American Society for Biochemistry and Molecular Biology’s 2018 Mildred Cohn Award in Biological Chemistry.
More rice, please: 13 rice genomes reveal ways to keep up with ever-growing population
Research | News
Rice provides 20% of calories consumed. As the population grows toward 9 billion and the climate shifts, we'll need to grow more rice in more places.
At CSHL, Congressman Suozzi celebrates scientific achievements of local HS students
Education | News
Congressman Suozzi hosts congratulatory event at CSHL for high school science competition winners, including two Partners for the Future participants
Evolving sets of gene regulators explain some of our differences from other primates
Research | News
What makes us different from our primate relatives? Gene regulation is one important evolutionary factor
New method can more precisely determine when a cell has ‘cashed’ RNA ‘checks’ written by active genes
Research | News
CSHL scientists have designed software that enables biologists to determine with unprecedented accuracy how much protein a given cell is making
Christina Renna Foundation raises $30,000 for continuing pediatric cancer research at CSHL
Institutional | News
The Christina Renna Foundation donates over $30,000 for rhabdomyosarcoma research, and honors Associate Professor Chris Vakoc with its research award
CSHL’s Rob Martienssen honored with prestigious Barbara McClintock Prize
Institutional | News
Plant geneticist Rob Martienssen awarded prestigious McClintock Prize
Counting chromosomes: Plant scientists solve a century-old mystery about reproduction
Research | News
Geneticists have solved a century-old mystery by discovering a remarkable mechanism that enables plants to count their chromosomes
YouTube videos earned her school a new lab from CSHL. Here’s how.
Education | News
Student wins back-to-back prizes from Silicon Valley. One such prize, a lab designed by CSHL’s DNA Learning Center, was awarded to her high school.
Molecular decoy helps researchers halt and reverse acute leukemia in mice
Research | News
By throwing a molecular wrench into the gears of a machine that sets genes into motion, researchers were able to get leukemias to 'melt away.'
A Cure Within documents the human stories behind cancer immunotherapy
Institutional | News
Immunotherapy as a cancer treatment may be cutting-edge, but it has a history. It’s the result of years of work by many dedicated researchers, some
CSHL’s Bo Li receives BRAIN Initiative funding
Research | News
CSHL Professor Bo Li and two collaborators at Oregon Health & Science University (OHSU) have been awarded a new grant under the BRAIN Initiative
A lesson in class
Research | Feature
In this episode of Base Pairs, we discuss how genetic information is changing how we define important categories.
David Spector is named ASCB Fellow
Institutional | News
David L. Spector was named a fellow of The American Society for Cell Biology
Dr. Anne Churchland honored with Marshall Award for promoting women in science
Institutional | News
Associate Professor Anne Churchland was honored with The Louise Hanson Marshall Special Recognition Award
Next Generation Lyme disease tests found efficacious and ready for clinical arena
Research | News
Experts find that current protocols for Lyme disease lacks the accuracy and sensitivity that next-generation testing can provide.
New method to determine before surgery which prostate tumors pose a lethal threat
Research | News
The news about prostate cancer can be confusing. It’s the third most common cancer type among Americans
Research profile: Leemor Joshua-Tor
Research | Feature
A CSHL faculty member since 1995, a professor since 2005, Joshua-Tor is among the most distinguished members of the Laboratory community.
Next-gen cancer test
Research | Feature
Knowing that cancers become lethal when they spread, investigators at Cold Spring Harbor Laboratory seek a way of detecting tumors much earlier
One experiment: A beautiful brain, neuron by neuron
Research | Feature
Associate Professor Pavel Osten and colleagues discovered using their qBrain method is discerned by probing hidden relations among the dots.
A transformative partnership
Institutional | News
New York Governor Andrew M. Cuomo visited Cold Spring Harbor Laboratory to break ground on the new $75 million Center for Therapeutics Research.
“Hi, my name is Brian”…“and I’m Andrea”
Research | News
We’re the hosts of Base Pairs, a podcast from Cold Spring Harbor Laboratory that tells stories about the power of genetic information—past, present an
Hungry for science
Institutional | News
The 12th annual Women’s Partnership for Science luncheon celebrated honorary director of the CSHL Association Freddie Staller.
Double Helix Medals dinner
Institutional | Feature
The 2017 Double Helix Medals were presented to Tom Brokaw and Helen Ann and Charles Dolan.
Welcome back, Dr. Myat
Education | News
Monn Monn Myat, Ph.D., is the new Associate Dean of the Watson School of Biological Sciences.
Additional brain power
Research | News
For neuroscientists, the brain presents an almost endless number of mysteries to be solved.
Toasting serendipity
Research | News
Four decades ago, scientists made a discovery that “completely transformed all of biology,” according to Nobelist James Watson.
Light, cryptochromes, action…
Research | News
Assistant Professor Ullas Pedmale has received the National Institutes of Health "Outstanding Investigator Award."
Hannon named director of Cancer Research UK Cambridge Institute
Education | News
Dr. Greg Hannon has been named the new director of the Cancer Research UK Cambridge Institute, effective February 1, 2018.
12th Double Helix Medals dinner raises $4.5 million for research & education at Cold Spring Harbor Laboratory
Institutional | News
More than $4.5 million was raised last night at Cold Spring Harbor Laboratory’s (CSHL) 12th Double Helix Medals dinner (DHMD).
Big decisions
Research | Feature
David Micklos of the DNA Learning Center, and Miriam Rich, a research scholar, talk about the big issues of eugenics.
Friends of T.J. present $50,000 gift for ongoing rhabdomyosarcoma research
Institutional | News
The Friends of T.J. Foundation presented CSHL Associate Professor Chris Vakoc with a check for $50,000 for his ongoing rhabdomysarcoma research
Fantastic journey: how newborn neurons find their proper place in the brain
Research | News
Neuroscientists have clarified the mechanism used by newly born neurons in mice to migrate to very specific areas.
New leadership roles in BRAIN Initiative and International Brain Lab reflect CSHL’s excellence in neuroscience
Research | News
The BRAIN Initiative Cell Census Network establishes a Center and a Collaboratory for the Mouse Brain Cell Atlas at Cold Spring Harbor Laboratory
Cryo-EM imaging suggests how the double helix separates during replication
Research | News
Special cryo-EM imaging helps figure out how the double helix of DNA separates when it replicates
Research revises our knowledge of how the brain learns to fear
Research | News
A team at Cold Spring Harbor Laboratory led by Professor Bo Li found evidence indicating the central amygdala is key to to aversive learning.
One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells
Research | Feature
Associate Professor Mikala Egeblad discovers that neutrophil extracellular traps (NETs) help cancer by creating holes in the tissue.
Masthead Cove Yacht Club raises over $6000 for CSHL research at annual race
Institutional | News
Members of the Masthead Cove Yacht Club (MCYC) raised $6,700 from their annual Masthead Race on August 13.
Good genes, bad science
Research | Feature
On this episode, Base Pairs looks into the eugenics movement, including the record kept in CSHL.
Governor Cuomo breaks ground on $75 million Cold Spring Harbor Laboratory Center for Therapeutics Research
Institutional | News
NY Governor Andrew M. Cuomo visited Cold Spring Harbor Laboratory (CSHL) this morning to break ground on the new $75 million Center for Therapeutics.
First cell-type census of mouse brains: surprises about structure, male-female differences
Research | News
A multiyear project in the Brain Initiative, qBrain is already revealing the brain as never before.
Do neuroscientists need to switch gears to understand how brains make choices?
Research | Feature
Associate Professor Anne Churchland, co-founder the IBL along with Professor Tony Zador, explains how it could help solve a problem in neuroscience.
16th Women’s Partnership for Science raises over $200,000 for disease research at Cold Spring Harbor Laboratory
Institutional | News
Cold Spring Harbor Laboratory held the 16th annual Women's Partnership for Science luncheon, a summer staple among New York's female philanthropists.
Neuron types in the brain are defined by gene activity that shapes their communication patterns
Research | News
Neurons are defined by determining which cells they connect with and how they communicate across synapses
What Silicon Valley and biology research share
Research | Feature
Further discussion with Associate Professor Gurinder "Mickey" Atwal about the need for more math and physics in biology.
Plant geneticists develop a new application of CRISPR to break yield barriers in crops
Research | News
Mutating regulatory regions varies yield traits the way a dimmer switch controls a light bulb
Research reveals “exquisite selectivity” of neuronal wiring in the cerebral cortex
Research | News
Inhibitory chandelier cells receive and transmit information from different ensembles of excitatory cells in their cortical neighborhood
2nd Annual WiSE Summer Party provides needed networking opportunity
Institutional | News
CSHL Women in Science and Engineering and the Postdoctoral Liaison Committee co-hosted the 2nd annual Greater NYC WiSE Summer Beach Party
Biology, behind the screens
Research | Feature
Associate Professor Gurinder "Mickey" Atwal talks about the essential mystery at the center of quantitative biology.
Structural view suggests RNAi machinery multiplies its efficiency in repressing gene expression
Research | News
Leemor Joshua-Tor publishes atomic-resolution pictures and an analysis of RNAi machinery
CSHL’s Kepecs receives BRAIN Initiative grant to develop tools to guide behavioral research
Institutional | News
Dr. Adam Kepecs receives grant to develop conceptual infrastructure for behavioral neuroscience research
Long-sought mechanism of metastasis is discovered in pancreatic cancer
Research | News
An epigenetic factor reprograms gene enhancers, enabling cancer cells to “remember” an earlier developmental state and causing metastasis.
Team traces masculinization in mice to estrogen receptor in inhibitory neurons
Research | News
CSHL researchers discover when ERα receptors are deleted in the brains of male mice, they do not exhibit typical "masculine" behaviors during puberty.
Library of CRISPR targeting sequences increases power and accuracy of the gene-editing method
Research | News
New library of RNA sequences that can be used by researchers to direct the CRISPR-cas9 complex to cut DNA with unprecedented precision.
Tomato baby and its family
Research | Feature
This episode of Base Pairs talks to Associate Professor Zachary Lippman about all the weird mutations that naturally occur in plants.
Freeze-frames of enzymes in action have implications for a new cancer treatment concept
Research | News
TUTase enzymes interact with let-7, a regulator of development; targeting them could help control certain cancers.
Newly identified small RNA fragments defend the genome when it’s ‘naked’
Research | News
Fragments snipped from tRNAs protect embryonic stem cells while they’re being epigenetically reprogrammed.
Over $300,000 raised for research and education at 24th annual golf outing
Institutional | News
Over 180 golfers took to the greens at Piping Rock Club at Cold Spring Harbor Laboratory’s 24th annual golf tournament.
Latest advances in malaria research in free eBook by Cold Spring Harbor Laboratory Press
Institutional | News
J.C. Flowers Foundation grant gives practitioners in malaria-endemic areas access to a critical resource
New statistical method finds shared ancestral gene variants involved in autism’s cause
Research | News
Researchers find children with autism are genetically more like other autistic children than their unaffected siblings.
CRISPR vs. climate change
Research | Feature
This episode of Base Pairs looks at the issues climate change may bring to agriculture and how CRISPR can help overcome them.
Open House brings 500+ new friends to Cold Spring Harbor Laboratory campus
Education Institutional | News
Cold Spring Harbor Laboratory (CSHL) welcomed 500+ new friends on June 10, 2017 to share the thrill of scientific discovery.
Detailed new ‘reference’ genome for maize shows the plant has deep resources for continued adaptation
Research | News
A new, much more detailed reference genome for maize, or corn, as it is called in the U.S., provides new insight into the crop.
A protein that stem cells require could be a target in killing breast cancer cells
Research | News
Cancer cells, like stem cells, have the ability to multiply indefinitely but epigenetic factor BPTF may be a shared weakness.
Fine-tuning dosage of mutant genes unleashes long-trapped yield potential in tomato plants
Research | News
Understanding gene interactions can enable breeders to break existing productivity barriers in agriculture.
Redefining biologists, redefining genes
Research | Feature
Drs. Molly Hammell and Thomas Gingeras talk about redefining what a biologist is and what genes are.
CSHL to lead international team developing next-generation organoid cancer research
Research | News
Cold Spring Harbor Laboratory (CSHL) has been awarded a research subcontract by Leidos Biomedical Research to lead a Cancer Model Development Center (CMDC) for pancreatic, breast, colorectal, lung, liver and other upper-gastrointestinal cancers.
Nobel laureate Dr. Carol Greider gives keynote at Cold Spring Harbor Laboratory graduation
Education | News
Eight new Ph.D.s join 90 alumni who have earned a degree from the Watson School of Biological Sciences in the 18 years since its accreditation.
Newly discovered mutations impair key cell pathways in pancreatic cancer
Research | News
Researchers have found important new clues to the development of pancreatic cancer.
Pershing Square Sohn cancer research prize awarded to CSHL’s Dr. Mikala Egeblad
Research | News
Cold Spring Harbor Laboratory (CSHL) Associate Professor Mikala Egeblad, Ph.D., has been awarded the Pershing Square Sohn Prize.
CSHL’s Dr. Leemor Joshua-Tor is elected to The National Academy of Sciences
Research | News
Professor Leemor Joshua-Tor has been elected to The National Academy of Sciences (NAS).
Cold Spring Harbor Laboratory to boost sharing of global scientific research in collaboration with the Chan Zuckerberg Initiative
Institutional Research | News
To accelerate the pace of scientific discovery, the bioRxiv preprint service will advance free distribution of research manuscript drafts.
Dark matter of the genome, part 2
Research | Feature
This episode of Base Pairs deals with the myth of "junk DNA" and why scientists are interested in non-coding portions of the genome.
CSHL’s Dr. Leemor Joshua-Tor Elected to American Academy of Arts and Sciences
Research | News
Professor Leemor Joshua-Tor is among 228 newly elected members of The American Academy of Arts and Sciences
New research explains why even targeted therapies eventually fail in lung cancer
Research | News
Dr. Sordella and her team propose a novel theory of how some cancers circumvent the killing power of targeted therapies.
Research suggests a possible role for a storm of ‘jumping genes’ in ALS
Research | News
New research demonstrates that some transposons are no longer effectively inhibited, resulting in a storm of jumping genes, leading to DNA damage.
Trinity College President Joins Board of Cold Spring Harbor Laboratory
Institutional | News
Dr. Joanne Berger-Sweeney, president of Trinity College, was elected to the CSHL Board of Trustees.
Protein complex that takes first steps in human DNA replication dance is captured at high atomic resolution
Research | News
Human ORC complex captured in action in x-ray crystallography and cryo-EM
Dark matter of the genome, part 1
Research | Feature
This episode of Base Pairs digs into "dark matter" a type of genetic information that could help scientists better understand diseases like
Dopamine neurons factor ambiguity into predictions that enable us to “win big and win often”
Research | News
Researchers describe how dopamine-releasing neurons weigh the ambiguity of sensory information, indicating that neurons are highly sophisticated.
The Children’s Heart Foundation awards $50,000 to CSHL researcher
Institutional | News
The New York Chapter of The Children’s Heart Foundation (CHF) presented Dr. Michael Ronemus of Cold Spring Harbor Laboratory (CSHL) a $50,000 grant.
Discovery of distinct cell subtypes around tumors helps explain why pancreatic cancer is so hard to treat
Research | News
Researchers finds that stroma,“wound”-like tissue that surrounds the tumors, helps explain why pancreatic cancer is so resistant to treatment.
Researchers identify “Achilles’ heel” of PTEN that helps drive prostate cancer progression
Research | News
Researchers at CSHL have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it.
CSHL statement regarding Executive Order on border security and immigration
Institutional | News
CSHL statement regarding Executive Order on border security and immigration
Molecules and a mission
Research | Feature
A special bonus episode of Base Pairs offering an explanation of why the name "Base Pairs" was chosen
In mouse model of Rett syndrome, research reveals how adult learning is impaired in females
Research | News
Researchers found that the failure of the Mecp2 gene, which leads to Rett syndrome, has biological consequences later in life.
Cancer research biobank formed by Northwell Health and Indivumed will enhance CSHL-Northwell alliance
Institutional | News
Northwell Health and Indivumed collaborate to greatly expand cancer biobanking activities within Northwell Health to develop medical approaches.
Relationship between incorrect chromosome number and cancer is reassessed after surprising experiments
Research | News
Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number, CSHL researchers found.
CSHL joins NCI-designated cancer centers in endorsing updated HPV vaccination recommendations
Institutional | News
Dr. Stillman and Dr. Tuveson joined with the leaders of other institutions nationwide in endorsing a statement regarding the HPV vaccine.
Plus-sized fly: a model to understand the mechanisms underlying human obesity
Research | News
The fly sheds light on how the brain acts to signal “fullness” and the possibility of conferring resilience against the impact of high-fat diets
FDA approval of life-saving SMA drug is hailed by its researcher-inventor at CSHL
Research | News
Nusinersen (Spinraza) will be used to treat young children with a severe and potentially fatal illness called spinal muscular atrophy (SMA).
The brain atlas
Research | Feature
This episode of BasePairs looks at the problems of neuropsychiatric drug discovery, and the method by which they may soon be resolved.
Dr. Robert Maki joins Northwell Health Cancer Institute and CSHL to direct Center for New Cancer Therapies
Research | News
Dr. Robert G. Maki an internationally-renowned sarcoma cancer physician and researcher, joins the leadership of the Northwell Health Cancer Institute.
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
Research | News
Truncated p53 proteins, presumed unimportant, now point to new drug targets for some of "the hardest cancers"
Gene editing yields tomatoes that flower and ripen weeks earlier
Research | News
Researchers use CRISPR to expand the geographical range of important food crops.
11th Double Helix Medals raises $4.3 million for biomedical research and education at Cold Spring Harbor Laboratory
Institutional | News
More than $4.3 million was raised last night at Cold Spring Harbor Laboratory’s 11th Double Helix Medals dinner, honoring Alan Alda and P. Roy Vagelos
One experiment: A drug for SMA visibly repairs defective cells
Research | Feature
Professor Adrian Krainer develops a treatment for spinal muscular atrophy, the leading genetic cause of infant death.
Detailed images of NMDA receptor show how zinc and a potential drug affect its function
Research | News
Drugs precisely targeting portions of the NMDA receptor may have applications in Alzheimer’s, depression and schizophrenia.
Dr. David Tuveson named Director, NCI-Designated Cancer Center at Cold Spring Harbor Laboratory
Institutional | News
Dr. David Tuveson, M.D., Ph.D., succeeds Dr. Bruce Stillman as Director of the Cold Spring Harbor Laboratory (CSHL) Cancer Center.
When antioxidants are pro-cancer
Research | Feature
For Pancreatic Cancer Awareness Month, Base Pairs looks at the science of antioxidants and cancer.
Focus on quiescent cells brings to light the essential role of RNA interference in transcription control
Research | News
RNAi and other epigenetic processes induce changes in where and when specific genes are expressed without altering their genetic code.
Pancreas and colon tumors reprogram the liver, causing wasting and short-circuiting body’s immune response
Research | News
Research reveals a mechanism that causes wasting in cancer and tests a way to reverse it.
Gene network controls how many flowers and fruits plants will produce during critical growth window
Research | News
Researchers use RNA sequencing to identify a network of genes that work together to determine the duration of a critical window for growth.
Our most common infection-fighting white blood cells can be hijacked to support cancer spread
Research | News
Neutrophils, the most common type of white blood cell, can be taken over by cancer cells and used as an aid in metastasis.
Masthead Cove Yacht Club raises over $7000 for CSHL research at annual race
Institutional | News
Members of the Masthead Cove Yacht Club (MCYC) raised $7,007 from their annual Masthead Race on August 14, 2016.
“Sink or swim”
Research | Feature
This episode of Base Pairs follows Professor Adrian Krainer and his experience as the first CSHL fellow.
Non-coding portions of genome are found to play role in cancer
Research | News
CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers.
Was it better or worse than you expected? Your basal ganglia know – so you can act accordingly
Research | News
Researchers have uncovered a neural circuit that processes evaluations and have succeeded in identifying its sources.
Innovative tools will shed clarifying light on inhibitory neurons
Research | News
Researchers at Cold Spring Harbor Laboratory created a set of tools that combine genetic markers and virus particles to target GABA cell types.
15th Women’s Partnership for Science luncheon features Lasker Prize winner Evelyn Witkin
Institutional | News
15th Annual Women's Partnership raises over $200,000 for disease research at Cold Spring Harbor Laboratory
The people problem
Research | Feature
This episode of Base Pairs looks at the rising population, plant biology, and the future of food.
Preprint server bioRxiv receives additional major funding
Institutional | News
Increased support will fuel continued growth and technical development of the increasingly prominent biomedical preprint service.
Revolutionary method to map the brain at single-neuron resolution is successfully demonstrated
Research | News
MAPseq can trace the long-range projections of large numbers of individual neurons from a specific region to wherever they lead in the brain.
Non-modern family
Education Research | Feature
This episode on Base Pairs explores how genetic information to better understand human history.
Candidate drug for spinal muscular atrophy, with roots in CSHL research, passes major hurdle
Research | News
Biotechnology firms Biogen and Ionis Pharmaceuticals cut short a phase-3 clinical trial for the investigational drug nusinersen as it met endpoint.
Novel drug therapy kills pancreatic cancer cells by reducing levels of antioxidants
Research | News
Researchers demonstrate that in the specific context of pancreatic cells leading to cancer, raisin antioxidant levels should not be raised.
To divide or not: a cellular feedback loop that enables new cells to make a fateful decision
Research | News
Team explains a key mechanism to prevent aberrant cell proliferation
Corn controversy
Research | Feature
This episode of Base Pairs covers the contentious genetics and history of America’s corn production.
Discovery of new ovarian cancer signaling hub points to target for limiting metastasis
Research | News
A team of researchers at Cold Spring Harbor Laboratory discovers new insights into signaling events that underlie metastasis in ovarian cancer cells.
Academic-industry collaboration generates elegant way of pinpointing how a new drug exerts beneficial effects
Research | News
Researchers identify a new drug target in leukemia and creation of a candidate drug that hits the target.
One experiment: How the breast “remembers” a first pregnancy
Research | Feature
Professor Greg Hannon and his team, including Assistant Professor Camila dos Santos, learn more about breast cells and tissue.
Cancer researcher Camila dos Santos of CSHL is named a Rita Allen Foundation Scholar
Institutional | News
Assistant Professor Camila dos Santos of Cold Spring Harbor Laboratory (CSHL) has been selected as one of seven 2016 Rita Allen Foundation Scholars.
“Amazing protein diversity” is discovered in the maize plant
Research | News
The genome of the corn plant “is a lot more exciting” than scientists have previously believed.
From phages to faces
Research | Feature
In the pilot episode of Base Pairs, two stories of DNA research that show how far the field has come
Pew Trusts name CSHL’s Daniel Rodríguez-Leal a Latin American Fellow in Biomedical Sciences
Institutional | News
Daniel Rodríguez-Leal, Ph.D., a postdoctoral investigator was selected for the Pew Latin American Fellows in the Biomedical Sciences
Pershing Square Sohn Cancer Research Alliance awards prize to CSHL’s Christopher Vakoc
Institutional | News
Associate Professor Christopher Vakoc of Cold Spring Harbor Laboratory is among seven winners of the third annual Pershing Square Sohn Prize
ALS Ride for Life comes to Cold Spring Harbor Laboratory
Institutional | News
CSHL gathered to welcome Chris Pendergast and his ALS Ride for Life team to campus on Monday, May 16.
Discovery of new stem cell pathway indicates route to much higher yields in maize, staple crops
Research | News
Researchers discover a new regulatory pathway that channels signals emanating from a plant's extremities to the stem cell niche.
Our brain uses statistics to calculate confidence, make decisions
Research | News
The brain produces feelings of confidence that inform decisions the same way statistics pulls patterns out of noisy data.
Cold Spring Harbor Laboratory confers 90th Ph.D.
Education | News
On May 1, proud friends and family mingled with distinguished scientists at the 13th commencement ceremony of the Watson School of Biological Sciences
First structural views of the NMDA receptor in action will aid drug development
Research | News
Structural biologists obtained snapshots of the activation of an important type of brain-cell receptor.
Cold Spring Harbor Laboratory launches $75 million Center for Therapeutics Research to develop new drugs
Institutional | News
CSHL announced the Center for Therapeutics Research project, applying biomedical expertise towards advancing therapeutics for genetic diseases.
Adrian Krainer of Cold Spring Harbor Laboratory elected to American Academy of Arts and Sciences
Institutional | News
Adrian Krainer was elected to the American Academy of Arts and Sciences.
Executive in Residence to mentor scientific entrepreneurs at Cold Spring Harbor Laboratory
Institutional | News
Andrew Whiteley joined the Cold Spring Harbor Laboratory Office of Technology Transfer as the first Executive in Residence.
CSHL scientists Bo Li and Je Lee win HFSP Research Grant awards
Research | News
Associate Professor Bo Li and Assistant Professor Je Lee, are among 25 teams that have won Human Frontier Science Program Research Program Grants
U.S. Patent Office denies all 4 petitions filed by Benitec Biopharma against CSHL’s shRNA patents
Institutional | News
U.S. Patent & Trademark Office has denied all 4 petitions filed by Benitec Biopharma Ltd seeking to invalidate CSHL's patents directed to shRNA.
Neanderthals mated with modern humans much earlier than previously thought, study finds
Research | News
Using several different methods of DNA analysis, an international research team has found what they consider to be strong evidence of interbreeding.
Ancient gene network helps plants adapt to their environments
Research | News
Reseachers discovered the purpose of a tool present in both mosses and flowering plants, organisms whose common ancestor dates back 450 million years.
A consortium to map the brain is launched
Research | News
The Wyss Institute for Biologically Inspired Engineering announced a cross-institutional consortium to map the brain's neural circuits.
Christina Renna Foundation Raises $35,000 for pediatric cancer research at CSHL
Institutional | News
The Christina Renna Foundation presented $35,000 to Cold Spring Harbor Laboratory (CSHL) at its 9th annual Angel's Wish Gala.
CSHL joins nation’s cancer centers in endorsement of HPV vaccination for cancer prevention
Institutional | News
Cold Spring Harbor Laboratory joined 68 other top cancer centers in issuing a statement urging increased HPV vaccination for the prevention of cancer
The iPlant Collaborative is now called CyVerse
Institutional | News
The enhanced NSF project will now provide data management and computation across scientific disciplines
bioRxiv preprints can now be submitted directly to leading research journals
Research | News
Cold Spring Harbor Laboratory announced that authors of manuscripts posted on its preprint server can now submit papers directly to leading journals.
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