
The digital dark matter clouding AI
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Scientists have unknowingly encountered mysterious noise while using AI to decipher our genetic code. CSHL has found a way to cut through the fog. Read the story »
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Scientists have unknowingly encountered mysterious noise while using AI to decipher our genetic code. CSHL has found a way to cut through the fog. Read the story »
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Before it can change the world, AI must learn to walk. To help get it there, Professor Anthony Zador has proposed a new ‘embodied’ Turing test. Read the story »
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This Special Annual Report edition of CSHL’s magazine provides a look back at some of the Laboratory’s biggest stories from 2022. Read the story »
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CSHL President & CEO Bruce Stillman sees the Laboratory as a global hub for scientific expertise and a powerful launchpad for early-career scientists. Read the story »
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The conversation around autism has evolved over the past two decades. So has CSHL research. This retrospective shows how we’ve helped move the needle. Read the story »
CSHL scientists have studied the genetics of autism across hundreds of family trees. This animated video shows what they’ve found. Watch the video »
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CSHL study of more than 6,000 volunteer families overturns a long-held assumption about the genetic origins of autism spectrum disorder. Read the story »
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With access to premier technology and expertise, CSHL primes early-career scientists for breakthrough studies of autism spectrum disorder. Read the story »
Different structures and artworks around campus hint at a history of groundbreaking molecular science. Take the quiz »
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June 3: The Cinema Arts Centre in Huntington, NY presents a screening of sci-fi romance Her with a talk on AI by CSHL neuroscientist Anthony Zador. Read the story »
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Friends, family, and faculty applauded 11 Ph.D. recipients at the CSHL School of Biological Sciences’ 2023 commencement. Read the story »
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Cheadle was selected for his leadership in neuroscience research and advancing diversity, equity, and inclusion in science. Read the story »
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The School of Biological Sciences awarded 11 Ph.D. degrees this year. Here, the graduates reflect on their time and experiences at CSHL. Read the story »
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The CSHL School of Biological Sciences awarded honorary degrees to author Stephen S. Hall and educator Nouria Hernandez. Read the story »
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This basic rule of thumb is helping CSHL’s quantitative biologists train AI to get a better read of the human genome. Read the story »
In this video, CSHL Assistant Professor Semir Beyaz shows how what you eat continues to influence your health long after you’ve digested it. Watch the video »
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CSHL researchers have found that high levels of a protein called SRSF1 can cause pancreatitis and jumpstart tumor development. Read the story »
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The award will support Tollkuhn’s research on the role of sex hormones in brain development, behavior, and diseases like Alzheimer’s and Parkinson’s. Read the story »
April is National Autism Awareness Month. Test your knowledge of autism spectrum disorders with this short quiz. Take the quiz »
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CSHL hosts the first-ever Science Forward symposium, a two-day event for early-career researchers from historically marginalized groups. Read the story »
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He helped pioneer the field. It changed medicine. Now, he joins a group of renowned scientists and physicians aiming to take it to the next level. Read the story »
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CSHL Professor Adrian Krainer, the man behind the “miracle drug” known as Spinraza®, has found a way to fight a deadly pediatric brain cancer in mice. Read the story »
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The same genes can cause different subtypes of tumors. Now, CSHL can recreate them in the lab. The approach could lead to new cancer treatments. Read the story »
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CSHL neuroscientists discover that certain neurons in the brain’s central amygdala are key to helping us learn about threats and rewards. Read the story »
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CSHL researchers have created a powerful new molecule that combats antibiotic-resistant superbugs. Read the story »
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A new algorithm created by CSHL researchers can help predict the health effects of millions of genetic variants found within a single person’s genome. Read the story »
Watch as the famed Italian actress chats with neuroscientist Helen Hou about Charles Darwin, women in STEM, stage fright, and much more. Watch the video »
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This Malaysian jungle plant produces a chemical with remarkable anticancer properties. Now, CSHL scientists can synthesize that chemical in the lab. Read the story »
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This spring, CSHL will introduce an app-connected, wheelchair-accessible trolley bus at its campus in Cold Spring Harbor, New York. Read the story »
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Explore the history of CSHL’s Meetings & Courses programs, along with their legacy of pioneering research and science education, from 1890 to today. Read the story »
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Perennials may hold the key to sustainable farming. CSHL scientists are decoding the genes that let these plants withstand the test of time. Read the story »
Step inside the lab of CSHL Associate Professor Jeremy C. Borniger, where he and his team are rewiring the nervous system to combat cancer cells. Watch the video »
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Imagine an electronic device that can eliminate tumors. In our exclusive interview, Jeremy Borniger offers an inside look at this exciting new field. Read the story »
This weekend, the worlds of art and science are one at CSHL as Rossellini presents her new play, Darwin’s Smile. Get your sneak peek here. Watch the video »
Take this 8-bit trip along the brain’s olfactory circuits to see what happens up there when you smell something. Watch the video »
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A shape-shifter with a protruding arm and an appetite for unwanted RNA! CSHL biochemists identify the hidden talents of a mysterious molecule. Read the story »
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Elementary, middle, and high school students on break can get real-life lab experience through a new series of science workshops at the DNALC. Read the story »
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The Cold Spring Harbor Laboratory School of Biological Sciences is now accredited by the New England Commission of Higher Education. Read the story »
The relationship between a mother and child is special. This video shows how moms’ brains are wired to reward motherly care. Watch the video »
Think you’re plugged into the latest artificial intelligence advancements? Test your tech knowledge with this quiz on AI and computational biology. Take the quiz »
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The generous gift supports CSHL’s Sarcoma Research Project and Professor Christopher Vakoc’s ongoing rhabdomyosarcoma research. Read the story »
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CSHL Partners for the Future student Sean Krivitsky is a semifinalist in one the nation's most prestigious high school science competitions. Read the story »
Test your knowledge of evolution with this quiz, inspired by the March 2023 performances of Isabella Rossellini’s play, Darwin’s Smile, at CSHL. Take the quiz »
Take an up-close look at what CSHL Professor Zachary Lippman describes as “one of the coolest evolutionary novelties to emerge in plants.” Watch the video »
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CSHL scientists have discovered that shutting down the ETV6 protein in Ewing sarcoma cells can dramatically slow their growth. Read the story »
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The DNALC Saturday DNA! sessions offer fun, interactive science workshops for students curious about genetics and how it affects everyday life. Read the story »
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Deerfield commits up to $130 million over 10 years to support drug development efforts. Read the story »
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Moms know best, but how do they learn it? A new study offers insights into the mental reward system that nurtures maternal instinct. Read the story »
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The money will help the Laboratory purchase new supercomputers and artificial intelligence equipment used in cancer research. Read the story »
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CSHL has effectively responded to the pandemic’s many challenges and is now better prepared for whatever the future may hold. Read the story »
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Inside the research to get neurons back in a healthy conversation with one another. Read the story »
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New software may help reveal the complete connections between ancestry and cancer, which could lead to better, more personalized treatments. Read the story »
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Scientists solve the mystery of how glioblastoma turns off cancer defenses without the usual cancer-inducing mutations. Read the story »
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New York Lieutenant Governor Antonio Delgado announced a $30 million investment to help fund the new construction project. Read the story »
CSHL continues to lead in biomedical sciences by fostering a collaborative, innovative, and high-risk, high-reward research community. Watch the video »
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Graduate student turned director of graduate studies, Zachary Lippman shares his vision for the CSHL School of Biological Sciences. Read the story »
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The humble aquatic duckweed plant has enormous potential as a new source of healthy protein, low-carbon biofuels, and other bioproducts. Read the story »
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AI’s popularity has reached a point where there are too many options. How do you know which AI is right for you? CSHL scientists have a solution. Read the story »
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Isabella Rossellini’s new one-woman show unpacks the origins of emotions, a place where the art of acting and the science of evolution come together. Read the story »
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Two separate studies from the Spector lab at CSHL suggest that certain genes can lead to cardiac problems. Read the story »
Pfizer Chairman and CEO Dr. Albert Bourla’s transformative leadership drove the development of the first FDA-approved COVID-19 vaccine. Watch the video »
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Four CSHL researchers were ranked among the world’s most cited in 2022. Read the story »
Dr. Jennifer A. Doudna won the 2020 Nobel Prize in Chemistry for developing the revolutionary gene-editing tool CRISPR-Cas9. Watch the video »
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The award, presented on World Pancreatic Cancer Day, honors Tuveson for his efforts to find a cure and improve patients’ lives. Read the story »
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CSHL President and CEO Bruce Stillman introduces a special issue of Nautilus magazine now online, featuring the Lab’s latest groundbreaking research Read the story »
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The new, modern seawall will protect the Laboratory and inner Cold Spring Harbor from climate change while preserving the wall’s historic character. Read the story »
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The gala, honoring Pfizer Chairman & CEO Albert Bourla and 2020 Nobel laureate Dr. Jennifer Doudna, raised $5.8 million for biological research. Read the story »
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Multimillion-dollar grants from the Chan Zuckerberg Initiative will support the Laboratory in sharing scientific breakthroughs worldwide Read the story »
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Biden’s Cancer Moonshot aims to cut annual deaths in half. CSHL scientists have the goal in their sights. Read the story »
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CSHL scientists’ new 3D models of NMDA brain receptor variants could lead to better treatments for schizophrenia, stroke, depression, and Alzheimer’s. Read the story »
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New genetic blueprints for two types of groundcherry may help strengthen food supplies and reveal how plants evolve. Read the story »
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A former student and faculty member at the School of Biological Sciences, Lippman takes on the new role effective December 1, 2022. Read the story »
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Smell remains the most mysterious of our five senses, but CSHL neuroscientists are now closer than ever to understanding it. Read the story »
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Fruit flies know if they’ve smelled an odor once, twice, many times, or never before. Read the story »
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CSHL scientists discovered a group of neurons in mouse brains that drive overeating. The findings could help develop better obesity treatments. Read the story »
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Collaboration and camaraderie inspire Breast cancer researcher Camila dos Santos’ team, Breast Friends, to succeed both in the lab and on the courts. Read the story »
The 31st season of CSHL volleyball once again fostered camaraderie and competition between friends and colleagues at the laboratory. Watch the video »
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Tuveson was recognized for his pioneering cancer organoid research that led to the development of the first mouse models for pancreatic cancer. Read the story »
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A medicine that disrupts the DNA replication of cancer cells may be within reach. Read the story »
Four teams braved the waters of Cold Spring Harbor in DIY rafts for glory and bragging rights in the seventh annual CSHL Raft Race. Watch the video »
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The high school team competed against universities and private labs to build a computer program for predicting gene expression in yeast. Read the story »
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The 2022 award, given to only 14 investigators, will support her pioneering research on the aging process. Read the story »
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Cheadle is CSHL’s first recipient of the NIH Director’s New Innovator Award. It supports his new work on inflammation and autism spectrum disorders. Read the story »
CSHL researchers and local donors came together for the first annual tree lighting ceremony to commemorate Pediatric Cancer Research Awareness Month. Watch the video »
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CSHL neuroscientists have discovered neurons in the brain, called tufted cells, are more powerful in recognizing odors than historically thought. Read the story »
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CSHL scientists discover cells called OPCs help shape developing brains by eliminating unnecessary connections. Read the story »
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The Cowley group creates computer models to study how the brain processes information gathered by the senses. Read the story »
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CSHL researchers found a drug that prevents lethal lung inflammation in mice, which may lead to better treatments for severe inflammatory conditions. Read the story »
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Researchers built a computer program that tracks harmful mutations throughout human evolution. It may help uncover the origins of genetic diseases. Read the story »
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The Westcott lab explores how the immune system shapes tumor evolution, with the goal of developing new cancer immunotherapies. Read the story »
The cheers, tears, thrills, and spills of the annual Meetings & Courses Plate Race returned to CSHL after two years away due to the COVID-19 pandemic. Watch the video »
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John R. Inglis was named an American Society for Cell Biology Fellow. He founded the CSHL Press and cofounded preprint servers bioRxiv and medRxiv. Read the story »
CSHL horticulturalists discuss how they design and foster the Laboratory’s beautiful landscapes to promote scientific inspiration and exchange. Watch the video »
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Tumors recruit the nervous system to help them spread. Scientists are looking for ways to stop it. Read the story »
CSHL Professor Michael Wigler discusses 20 years of research to paint a complete picture of the genetic causes of autism. Watch the video »
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One geneticist is determined to piece together the causes of autism. Read the story »
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CSHL scientists identified, for the first time, the RNA in humans used to train T cells to attack dangerous or foreign proteins in the body. Read the story »
Dive into the 3D atomic structure of the NMDA receptor, important in several brain disorders, and see how it interacts with drugs that inhibit it. Watch the video »
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CSHL researchers have found mini-versions of patient tumors, called organoids, can help optimize chemotherapy before tumor-removal surgery. Read the story »
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The DNALC is transforming how science is taught, using hands-on research programs to keep students from historically excluded communities in STEM. Read the story »
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Molecules called antisense oligonucleotides may help lung cells make a protein missing in people with cystic fibrosis. Read the story »
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Pairing Spinraza® with a second FDA-approved drug may be a new way to improve the drug’s therapeutic effects in spinal muscular atrophy patients. Read the story »
A recorded webinar featuring CSHL Professor Anthony Zador on how lessons from the brain can help build better artificial intelligence programs. Watch the video »
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The Hou Lab will explore how the brain controls movement and behavior, including how it makes facial expressions and conveys emotion. Read the story »
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The Long Island Herald recognized CSHL President and CEO Bruce Stillman for his leadership and impact in the biomedical field. Read the story »
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Tuft cells in the lungs can turn into cancer. CSHL scientists have found a way to get in the way of tuft cell development. Read the story »
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Maternal care offers a window on our social behaviors. Read the story »
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Businessman Mark L. Claster joins the CSHL Board of Trustees. Read the story »
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Indiana University School of Medicine honored Krainer for his pioneering work on RNA splicing, which led to the first FDA-approved SMA therapeutic. Read the story »
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Janowitz received a $25 million grant to take on cachexia. This debilitating condition is responsible for up to 30% of cancer-related deaths. Read the story »
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CSHL Professor Anthony Zador has developed mapping and barcoding technologies that identify brain cell connections. Read the story »
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CSHL researchers have found a new way to control plant growth by manipulating proteins involved in the process of detecting light. Read the story »
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CSHL scientists explore new angles to improve brain disorder therapies with 3D maps of the NMDA receptor, a key player in Alzheimer's and epilepsy. Read the story »
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Artificial Intelligence (AI) experts at CSHL are creating better AI by deciphering brain circuits. Read the story »
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CSHL postdoc Simón(e) Sun was selected as a 2022 Leading Edge Fellow for her work on the protein estrogen receptor beta and its role in the nervous system. Read the story »
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The Argonaute protein is a workhorse for cell regulation and CSHL researchers discovered what helps it commute from job to job. Read the story »
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Strategically designed to spark scientific exchange and inspiration, CSHL is a unique research and education environment for advancing science. Read the story »
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Assistant Professor Arkarup Banerjee receives a $300,000 award to study brain circuits involved in vocalization. Read the story »
Researchers have designed an antibody that may help treat brain disorders. See how it prevents neurons from malfunctioning. Watch the video »
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CSHL scientists leveraged lessons from the corn genome to improve another global staple crop, rice. Read the story »
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Corina Amor, a CSHL Fellow and Cancer Center member, has been named a top entrepreneur and scientist in Forbes 30 Under 30 Europe list. Read the story »
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CSHL’s head of Diversity, Equity & Inclusion Charla Lambert helps scientists apply their unique identities and perspectives from all walks of life. Read the story »
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Plant researchers and breeders are now using a website created by CSHL to get the latest intel on sorghum crop research. Read the story »
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Researchers have mapped the genes estrogen uses to establish male and female neural circuits during brain development in mice. Read the story »
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In May 2022, the CSHL School of Biological Sciences awarded 10 Doctor of Philosophy degrees and two honorary degrees. Read the story »
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CSHL Press Executive Director John R. Inglis and Assistant Director Richard Sever were recognized with honorary Doctor of Science degrees. Read the story »
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The School of Biological Sciences awarded Ph.D. degrees to ten students this year. Here are some stories and memories from their time at CSHL. Read the story »
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CSHL Professor and HHMI Investigator Rob Martienssen joins the American Academy of Arts and Sciences. Read the story »
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CSHL Professor John E. Moses was awarded over $325,000 from the New York State Biodefense Commercialization Fund to study a new type of antibiotic. Read the story »
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Breeding a variety that can withstand disease and taste better too Read the story »
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Tumors grow when cells lose their biological identity. A promising therapeutic might restore their sense of self. Read the story »
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Online or on-campus, the CSHL bookstore has you covered. Shop this small oasis below Grace Auditorium for science books, toys, clothes, and souvenirs. Read the story »
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See how the Laboratory adapted its education and live programming during the pandemic. Read the story »
New research is constantly sprouting. Take this quiz and test your plant knowledge. Take the quiz »
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Researchers collected a biobank of triple-negative breast cancer mini-tissues to search for new and potentially patient-specific treatments. Read the story »
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It pays to check whether genetic tweaks that improve one kind of crop could get foiled by backup genes in a different crop. Read the story »
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She studies the genetic and environmental factors that steer brain development. Read the story »
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Neuroscientists found an ancient part of the mouse brain may coordinate maternal protective behaviors. Read the story »
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Three high school student researchers at CSHL were among Regeneron Science Talent Search’s top 300 scholars. One made it to the final competition. Read the story »
Cold Spring Harbor Laboratory is pretty, but did you ever notice what it sounds like? We did . . . and turned the unique soundscape into music. Watch the video »
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Dicer and its partner BRD4 stabilize chromosomes. Targeting this pair could provide new therapeutic opportunities against cancer. Read the story »
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See how the Laboratory adapted its research, education, and live programming, by the numbers. Read the story »
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The CSHL board elected two new trustees at the March 10, 2022 board meeting. Read the story »
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Microglia cells nurture connections during brain development, which contrasts to the cells’ previously understood role in pruning connections. Read the story »
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Researchers discovered the same optimization algorithm used by Internet engineers is used by ants when they forage for food. Read the story »
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Neuroscientists are turning to artificial intelligence to help them understand the brain, but what if AI misses the true story? Read the story »
This robotic assistant gives chemists a hand in the lab. Watch the video »
Find out how cancer cells shield themselves from the immune system using a coat of armor and confusing signals. Watch the video »
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A complex of proteins secreted by tumor cells can immobilize an important component of the immune system. Read the story »
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Mutations are not random, with some kinds of changes occurring more often than others. CSHL researchers may be able to predict which direction evolution is li Read the story »
Severe lung infections (like SARS-CoV-2) can trigger a deadly cascade of immune events. In animal models, disulfiram can prevent a very toxic step. Watch the video »
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An over-the-counter heartburn drug shows promise in reducing several COVID-19 symptoms in a fully-remote outpatient clinical trial. Read the story »
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In two rodent studies, CSHL researchers found how disulfiram decreases immune-mediated damage after lung injury or infection with SARS-CoV-2. Read the story »
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CSHL researchers developed a way to interfere with the energy pathway that allows liver cancer to grow and spread. Read the story »
See the shapes and speeds of electrical waves in the brain change in response to attentiveness. Watch the video »
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CSHL researchers found that the brain’s state of attentiveness may be encoded in the shapes and speeds of slow electrical waves. Read the story »
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As arable land disappears, a genetic tweak might secure the world’s food supply. Read the story »
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CSHL researchers found a new way to address a previously untreatable class of mutations in the cystic fibrosis gene. Read the story »
Researchers are using tiny versions of clinical machines to improve early tumor detection. In this video, we see a tiny version of a SPECT-CT scanner. Watch the video »
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Diverse: Issues In Higher Education magazine named CSHL Assistant Professor Lucas Cheadle a top “40 and under” scholar. Read the story »
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CSHL Professor Anthony Zador and Veranome Biosystems are collaborating to improve brain mapping technology using engineering solutions. Read the story »
Plants relay messages critical for development between their cells using RNA. See tiny RNA messages zoom around inside plant cells. Watch the video »
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CSHL scientists discovered a way plants send messages between cells using RNA and a protein escort. Read the story »
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CSHL scientists find that a protein previously unknown to cancer researchers may hold the key to targeting acute myeloid leukemia. Read the story »
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Corina Amor is the newest fellow at CSHL. She studies immunology and aging. Read the story »
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