The “ORC” twists, pinches, and dances around DNA
The Origin Recognition Complex (ORC) is a key piece of cellular machinery, fundamental to life, yet so far mysterious. Watch the video »
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CSHL Stories and Media
Replicating a genome starts with a twist, a pinch, and a bit of a dance
News
Researchers have their first high resolution look at how “ORC,” a human protein complex essential to life, moves. Read the story »
The motivation center of the mouse brain in 3D
A 3D-model of the mouse brain (gray) showing the dorsal striatum (green), which includes the striosome. Model: Allen Brain Atlas Watch the video »
Reward and punishment take similar paths in the mouse brain
News
One brain structure is involved with both positive and negative reinforcement types of learning. Read the story »
Immune cells sculpt circuits in the brain
News
Immune cells play an unexpected role in fine-tuning the brain’s neural circuits. Read the story »
Leshan, Lippman address “Life Science Across the Globe” series
News
Professor Zach Lippman and Executive Director of the Banbury Center Rebecca Leshan give talks as part of the “Life Science Across the Globe” series. Read the story »
Stress, sleep, and immunity
News
Researchers found the brain circuit that connects stress-induced insomnia and the immune system in mice. Read the story »
New genetic research to understand racial disparity in cancers
News
Cold Spring Harbor Laboratory will study the genetic contributions of ethnicity to colon, endometrial, and pancreas cancers in African Americans. Read the story »
COVID-19 or not, CSHL workers are on the job
News
A look at some of the many CSHL employees who have worked to keep the Laboratory running with new safety precautions and online offerings. Read the story »
Human Nature documentary panel discussion
CRISPR experts, including Professors Zach Lippman, Jennifer Doudna, and Alta Charo discuss the gene-editing technology and its use. Watch the video »
CSHL hosts Human Nature documentary panel with CRISPR experts
News
CRISPR experts, including Professors Zach Lippman, Jennifer Doudna, and Alta Charo discuss the gene-editing technology and its use. Read the story »
CSHL works to improve communication with PSEG on outages
News
CSHL’s Chief Facilities Officer Steve Monez is advocating for better communication and oversight from PSEG in the aftermath of Tropical Storm Isaias. Read the story »
Understanding the inner workings of the human heart
News
Scientists show that muscular structures first described by Leonardo da Vinci are essential for heart function. Read the story »
Why we’re a lot better at fighting cancer than we realized
Feature
Using data mining techniques, doctors have discovered dozens of anti-tumor drugs hiding in plain sight. Read the story »
Cold Spring Harbor Laboratory’s class of 2020
News
Meet the seven graduates of the Cold Spring Harbor Laboratory School of Biological Sciences. Congratulations to all. Read the story »
How the senses shape the brain
News
Neuroscientist Lucas Cheadle joins CSHL neuroscience faculty, and studies how outside stimuli affect brain development. Read the story »
Martienssen named 2020 Royal Society winner
News
Professor and HHMI Investigator Rob Martienssen wins a 2020 Royal Society medal for his RNAi research. Read the story »
Live @ the Lab with David Tuveson: Studying pancreatic cancer
Cold Spring Harbor Laboratory Cancer Center Director Dave Tuveson presents an exciting new model for studying pancreatic cancer. Watch the video »
ENCODE3: Interpreting the human and mouse genomes
News
Researchers report on 900,000 regulatory elements in our genomes that could influence our health. Read the story »
Cancer researchers discuss COVID-19’s effect on the field
News
Dr. David Tuveson and Dr. Tobias Janowitz discuss in Cancer Discovery how the COVID-19 pandemic has changed cancer research. Read the story »
The first mouse model of human pancreas cancer subtypes
News
CSHL researchers discovered how slow-growing pancreatic tumors can switch into a more deadly sub-type. Read the story »
How two CSHL programs adapted during the COVID-19 pandemic
News
Mikala Egeblad and David Micklos presented their work at the “Life Science Across the Globe” seminar series. Read the story »
How breast cancer cells sneak past local immune defenses
News
Breast cancer cells sabotage nearby immune cells to evade detection and destruction by the body’s defenses. Read the story »
How to map brain connections using DNA barcodes
News
A new technique labels brain cells with short snippets of DNA to trace many neuronal connections at a time. Read the story »
CSHL tops Bush Center’s Innovation Impact Productivity Score
News
Cold Spring Harbor Laboratory ranks #1 in Innovation Impact Productivity Score among Pure Research/Health Care Institutions by the Bush Center. Read the story »
Who COVID-19 hit hardest in New York
News
Report on nearly 50,000 New Yorkers tested for COVID-19 reveals demographics, hospitalization rates for positive patients. Read the story »
Krainer wins 2020 NYAS Innovators prize for SMA research
News
Professor Adrian Krainer is the 2020 Senior Scientist Winner of the Innovators in Science Award for his work on SPINRAZA®. Read the story »
Blocking cholesterol storage could stop growth of pancreatic tumors
News
Interfering with the way pancreatic cancer cells process and store cholesterol can stop a tumor from growing. Read the story »
The world destroyer in your shampoo and ice cream
Feature
Palm oil is an environmental scourge. Genetics has a solution. Read the story »
CSHL trustees vote on future of graduate school
News
The CSHL Board of Trustees voted to restore the original name of the graduate program to the Cold Spring Harbor Laboratory School of Biological Sciences. Read the story »
CSHL Center for Humanities wins NEH Grant
News
The CSHL Center for Humanities & History of Modern Biology wins a CARES Act Grant for its extensive oral history initiative. Read the story »
Brain receptor pulls open electrical gate like a puppet master
News
When stimulated by a neurotransmitter or drug, the NMDA receptor pulls open an ion gate that allows ions to flow. Read the story »
How does the NMDA receptor work?
CSHL Professor Hiro Furukawa describes how the NMDA receptor opens and closes its ion channel. Watch the video »
CSHL joins “Life Science Across the Globe” seminar series
News
CSHL will present two talks at the “Life Science Across the Globe” seminar series on July 8. Read the story »
New evidence for how blood clots may form in very ill COVID-19 patients
News
The amount of NETs in COVID-19 patients’ blood vessels correlates with the severity of their disease. Read the story »
Nobelist Sir Richard Roberts talks GMOs at CSHL
News
Nobelist and CSHL alum Sir Richard Roberts spoke about GMOs and the future of agriculture with Pamela Ronald and Rob Martienssen. Read the story »
Nobelist Sir Richard Roberts talks GMOs at CSHL hosted event
Nobelist and CSHL alum Sir Richard Roberts spoke about GMOs and the future of agriculture with Pamela Ronald and Rob Martienssen in this video. Watch the video »
Chan Zuckerberg Initiative awards $2 million to medRxiv
News
CZI partners with Cold Spring Harbor Laboratory, Yale University, and BMJ to help scientists share health and clinical research faster. Read the story »
How chandelier cells light up the brain
News
Until now, chandelier cells were largely enigmatic, but new technology makes them accessible to researchers. Read the story »
The DNA tricks that gave us 100 different kinds of tomatoes
News
It takes 230,000 genetic differences to make 100 different varieties of tomatoes. Read the story »
Siddhartha Mukherjee discusses The Gene in virtual lecture
News
Author Siddhartha Mukherjee discusses the history and future of genetics in a virtual public lecture. Read the story »
Siddhartha Mukherjee discusses THE GENE: An Intimate History
Acclaimed author and oncologist Dr. Siddhartha Mukherjee spoke from his home via video conference to over 400 virtual attendees at the CSHL Library. Watch the video »
Applying symptom tracking to COVID-19 outpatient care using famotidine
News
Researchers from CSHL and Northwell Health are developing a way to test promising COVID-19 drugs, like famotidine, by tracking outpatient symptoms. Read the story »
CSHL President Bruce Stillman wins Heineken Prize
News
CSHL President and CEO Bruce Stillman wins the Heineken Prize for his work on eukaryotic DNA replication. Read the story »
CSHL projects education outward
Feature
The CSHL DNA Learning Center is leading the education field in building virtual, interactive science experiences. Read the story »
CSHL is changing scientific exchange
Feature
The Lab leads the way in moving from on-site meetings and courses to virtual modes of scientific exchange. Read the story »
Pregnancy reprograms breast cells, reducing cancer risk
News
CSHL researchers discovered that pregnancy reprograms breast cells, reducing the risk of breast cancer in women under 25. Read the story »
How an antiviral immune reaction can go too far
News
White blood cells sacrifice themselves to ensnare invaders in a sticky NET (neutrophil extracellular trap), but in COVID-19, NETs may hurt us. Read the story »
Teachers make genomes more useful… from home
News
Researchers and educators participated in an online annotation jamboree to help researchers understand the corn genome. Read the story »
Why pancreatic ductal adenocarcinoma is so lethal
News
CSHL researchers discovered factors that allow a pancreatic cell to lose its identity and turn into an aggressive cancer cell. Read the story »
Smoking increases SARS-CoV-2 receptors in the lung
News
An increase in lung ACE2 may explain why smokers are particularly vulnerable to COVID-19. Read the story »
Coronavirus research in plants
News
Purified coronavirus proteins are in short supply for COVID-19 researchers, so CSHL plant scientists are jumping in to make them. Read the story »
Tuveson and Wigler elected AACR Academy Fellows
News
CSHL Cancer Center Director David Tuveson and Professor Michael Wigler were chosen as 2020 Fellows of the AACR Academy. Read the story »
How to tune out common odors and focus on important ones
News
The fly brain uses a simple computing trick to ignore prevalent odors and focus on newer but rarer odorants. Read the story »
What do these scientist moms do? Ask their kids.
News
We asked the children of three scientists to describe their mother’s work. See what they had to say. Read the story »
Dog adaptations are like brain adaptations
News
To understand autism, CSHL Professor Michael Wigler thinks about how biological systems adapt over generations. Read the story »
The status of autism research—in verse
Feature
CSHL Professor Michael Wigler drafted a poem explaining what we know and what we need to learn about autism. Read the story »
Adrian Krainer elected to the National Academy of Sciences
News
Professor Adrian Krainer was elected to the National Academy of Science as part of its 2020 election. Read the story »
A science career path: Jason Williams
Blog
He is now a leader at the DNA Learning Center, the place that taught him to love biology in high school. Read the story »
How NETs harm lungs
Are NETs present in human ARDS, like during fulminant coronavirus infections? Could breaking up NETs help cure patients? Watch the video »
David Tuveson named President-Elect of AACR
News
CSHL Cancer Center Director David Tuveson has been elected President-Elect of the American Association for Cancer Research. Read the story »
Charting a new field of cancer neuroscience
News
A Banbury Center meeting of 35 experts proposes a new field to study the relationship between cancer and neuroscience. Read the story »
Global NETwork studies role of immune cells in COVID-19 deaths
News
The symptoms of severe COVID-19 disease may be caused by overactive white blood cells that produce gauzy webs of DNA laced with toxic enzymes called NETs. Read the story »
One experiment: DNA barcoding
Feature
High school students at the DNA Learning Center collect, process, and sequence the DNA, contributing to the scientific record of biodiversity. Read the story »
Predicting the evolution of genetic mutations
News
CSHL quantitative biologists have designed a computational approach for predicting the evolution of a rapidly mutating virus or cancer. Read the story »
A science career path: David McCandlish
Blog
Assistant Professor David McCandlish is a quantitative biologist who walks the line between advanced mathematics and the life sciences at CSHL. Read the story »
Zachary Lippman wins Charles Albert Shull Award
News
Professor Zachary Lippman is the 2020 Charles Albert Shull Award winner, an honor given by the American Society for Plant Biology. Read the story »
CSHL featured in new Ken Burns documentary, The Gene
News
The documentary will feature CSHL Professor Adrian Krainer, materials from the CSHL Library & Archives, and glimpses of the CSHL campus. Read the story »
Pursuing COVID-19 at internet speed
Feature
As scientists grapple with the COVID-19 global pandemic, preprint servers bioRxiv and medRxiv let information be free—and fast. Read the story »
Carol Greider: Nobel Prize-winning rogue biologist
Feature
CSHL alumna Carol Greider won the Nobel Prize and is a champion for diversity. But her dyslexia almost derailed her career before it began. Read the story »
Speed sharing of COVID-19 research results
News
The cofounders of bioRxiv and medRxiv explain preprint servers and how they are contributing to ending the pandemic. Read the story »
New faculty Jeff Boyd studies breast cancer genomics
News
Professor Jeff Boyd joins the CSHL faculty, studying the growth and spread of breast cancer. Read the story »
COVID-19 machine learning effort: Preprints are key
News
Preprint papers play a key role in a U.S. government-led machine learning effort to understand the COVID-19 pandemic. Read the story »
Barbara McClintock: Free to discover
Feature
Nobel laureate Barbara McClintock spent half her life at CSHL, enjoying the freedom to explore new ideas and ignore criticism. This is her journey. Read the story »
Why your kid can explain the COVID-19 test
News
Want to know more about PCR and the coronavirus test? Ask a high school student, especially one that worked with the DNA Learning Center. Or… read on. Read the story »
Images of ‘invisible’ holes on cells may jumpstart research
News
Cellular pores, once impossible to see, have been imaged for the first time. This sets the stage for new discoveries about blood pressure and pain. Read the story »
Adrian Krainer wins Ross Prize in Molecular Medicine
News
Professor Adrian Krainer wins the Ross Prize for his pioneering work on antisense therapy and its application to treating SMA. Read the story »
Christina Renna Foundation donates $38k to study sarcoma
News
The Christina Renna Foundation donated $38,000 to the lab of Professor Chris Vakoc. Read the story »
Congressman Suozzi honors Regeneron scholars at CSHL
News
Congressman Tom Suozzi congratulated Regeneron semi-finalists, including two Partners for the Future, at a ceremony hosted at CSHL. Read the story »
Extra chromosomes in cancers can be good or bad
News
Extra chromosomes are typical in cancerous tumor cells, but not all extra copies promote cancer growth. Read the story »
The future of food looks small, dense, and very bushy
Feature
Vertical farming could make agriculture more robust and sustainable. To unlock that potential, scientists are redesigning crops for urban life. Read the story »
Science of love quiz
Scientists are on the trail of finding out what makes people fall in love. Test your knowledge on the science of love. Take the quiz »
Tatiana Engel named 2020 Sloan Fellow
News
Assistant Professor Tatiana Engel is named a 2020 Sloan Fellow for her work on computational models of decision-making. Read the story »
Cracking the case of the norovirus
Feature
A pervasive virus has evaded vaccine developers for decades. By getting a clear look at its protective shell, they may finally know how to defeat it. Read the story »
How cancer metabolism could be key for new therapies
News
Assistant Professor Michael Lukey joins the CSHL faculty, studying metabolic reprogramming events in cancer. Read the story »
Jason Williams wins NSF 2026 Idea Machine Competition
Jason Williams has been awarded the Meritorious Prize in the National Science Foundation (NSF) 2026 Idea Machine Competition. Watch the video »
Jason Williams wins NSF 2026 Idea Machine Competition
News
Jason Williams of the DNA Learning Center is a Meritorious Prize winner of the NSF’s 2026 Idea Machine Competition. Read the story »
Mutation’s role in blood cancers revealed by ideal team-up
News
Researchers from CSHL and MSKCC have determined how a mutation implicated in many blood cancers reduces the proteins that make healthy blood cells. Read the story »
Mutation’s role in blood cancers revealed by ideal collaboration
Researchers from CSHL and MSKCC have determined how a mutation implicated in many blood cancers reduces the proteins that make healthy blood cells. Watch the video »
UN delegates engage with scientists at CSHL
News
Eleven delegates from the UN visited CSHL to learn more about the Lab’s research and education programs. Read the story »
Studying what connects cancer and the brain
News
Assistant Professor Jeremy Borniger joins the CSHL faculty to study the link between the brain and cancer. Read the story »
New look at odd holes involved in taste, Alzheimer’s, asthma
News
Large holes in our cells have been implicated in depression, Alzehimer’s disease, asthma, and even taste. Now, we know what two of these pores look like. Read the story »
Lippman wins NAS Prize in Food and Agriculture Sciences
News
CSHL Professor and HHMI Investigator Zachary Lippman was awarded the NAS Prize for his work in the field of plant genetics. Read the story »
New tool for investigating brain cells, Parkinson’s, & more
Researchers have created a new chemical tool for revealing how specific types of brain cell receptors function in the brain. Watch the video »
New tool for investigating brain cells, Parkinson’s, & more
News
Researchers have crafted a compound for targeting specific brain cell receptors, creating new opportunities to study the brain and Parkinson’s disease. Read the story »
What Google could learn from a fruit fly
Feature
By tapping into life’s algorithms, scientists are finding elegant solutions to some of the hardest problems in computer science. Read the story »
Jason Williams named 2020 Kavli Frontiers of Science fellow
News
Jason Williams, Assistant Director of External Collaborations at the DNA Learning Center, was chosen for 2020 Kavli Frontiers of Science symposium. Read the story »
Vitamin B6, leukemia’s deadly addiction
News
Acute Myeloid Leukemia is addicted to vitamin B6. Now that researchers know this, they can pursue new treatment options for the deadly blood cancer. Read the story »
Vitamin B6, leukemia’s deadly addiction
Acute Myeloid Leukemia is addicted to vitamin B6. Now that researchers know this, they can pursue new treatment options for the deadly blood cancer. Watch the video »
CSHL Cancer Center joins the AACI
News
The CSHL Cancer Center becomes the 100th member of the Association of American Cancer Institutes. Read the story »
The non-human living inside of you
Feature
A large part of human DNA doesn’t aid the normal workings of the body. This “junk DNA” contains ancient viruses that may spur diseases like ALS. Read the story »
Abnormal neuron activity manifests as parental neglect
News
Without the gene Mecp2, mice can’t learn to care for crying pups. Knowing when the brain is able to learn may help treat developmental disorders. Read the story »
How the brain balances pleasure and pain
News
The brain balances signals that either excite or inhibit neurons and influence the motivation of an animal to seek a reward or avoid punishment. Read the story »
Finally, machine learning interprets gene regulation clearly
News
Machine learning and a new kind of easily-interpretable artificial neural network is helping scientists make sense of crucial gene regulation. Read the story »
A new tomato ideal for urban gardens and even outer space
News
Researchers used CRISPR gene editing to optimize tomatoes for urban agriculture, preparing them for the city rooftops and possibly space missions. Read the story »
Mikala Egeblad wins Marks Foundation ASPIRE Award
News
Associate Professor Mikala Egeblad received the ASPIRE award to fund research understanding the relationship between stress and metastasis. Read the story »
Shifting the balance of growth vs. defense boosts crop yield
News
Researchers found that a specific gene in maize balances both growth of the plant and its immunity. Read the story »
Saket Navlakha taps the power of biology and computers
News
Associate Professor Saket Navlakha is bringing ideas about “algorithms in nature” to the Simons Center for Quantitative Biology. Read the story »
Ann Lin named in Forbes 30 Under 30 list for 2020
News
Ann Lin, a former intern in CSHL Fellow Jason Sheltzer’s lab, has been named a top entrepreneur on the Forbes 30 Under 30 list. Read the story »
Bridge to education
Feature
CSHL’s DNA Learning Center builds new bridges between unique science education and diverse groups. Read the story »
DNA Learning Center takes New York
News
DNA Learning Center is expanding its educational reach into the greater New York area through the opening of two new centers. Read the story »
A new DNA Learning Center at Regeneron
News
Regeneron Pharmaceuticals and CSHL partner to open a new DNA Learning Center in Sleepy Hollow, NY. Read the story »
CSHL investigators rank among world’s most highly cited
News
Seven researchers affiliated with CSHL are among the scientists producing the top 1 percent of the most highly-cited research in the world. Read the story »
Nobel Prize day quiz
How much do you know about the Nobel Prize-winning science that happened at CSHL? Take our quiz to find out. Take the quiz »
Researchers identify gene behind spread of deadly breast cancer
News
Jackson Laboratory and Cold Spring Harbor Laboratory researchers uncovered novel targets for therapies related to deadly triple negative breast cancers. Read the story »
Making sense of the genome…at last
Feature
Quantitative biologists like Cold Spring Harbor Laboratory’s Adam Siepel are finally making sense of the flood of data contained in the human genome. Read the story »
The Lab partners with award-winning magazine
News
Nautilus, an award-winning science magazine, has partnered with CSHL to bring the story of the lab’s scientists and research to a brand-new audience. Read the story »
CSHL wins TD Ready Challenge grant for organoid facility
News
CSHL is one of the recipients of the TD Ready Challenge grant to help support the upcoming organoid facility. Read the story »
New trustees bolster CSHL board
News
Cold Spring Harbor Laboratory welcomes three new members to its Board of Trustees. Read the story »
Adrian Krainer wins 2019 Peter Speiser Award
News
Professor Adrian Krainer was awarded the Peter Speiser Award for advances in the pharmaceutical sciences. Read the story »
Nicholas Tonks named 2019 AAAS Fellow
News
CSHL Professor Nicholas Tonks is being honored as a 2019 AAAS Fellow for his work on signal transduction and the discovery of PTP. Read the story »
Fresh insights into prostate cancer surprise Movember crowd
Blog
For a special “Movember” edition of Cocktails and Chromosomes, Dr. Lloyd Trotman explained what his lab is doing to understand deadly prostate cancers. Read the story »
Movember with Lloyd Trotman—A Cocktails and Chromosomes talk about prostate cancer
In this Movember edition of Cocktails & Chromosomes, learn how new concepts of cancer evolution could turn prostate cancer into a curable disease. Watch the video »
Milestone reached in new leukemia drug
News
Salt-Inducible Kinase 3 (SIK3) could be a good therapeutic candidate for treating MLL translocation positive subtype of leukemia. Read the story »
The difference between an expert’s brain and a novice’s
News
Researchers use computational models to observe how changing neural activity can help mice learn new tasks and make better decisions. Read the story »
Research profile: Adam Siepel
Feature
Adam Siepel, Chair of the Simons Center for Quantitative Biology, uses advanced computational methods to solve complex biological questions. Read the story »
Vakoc wins Paul Marks Prize for cancer research
News
Professor Chris Vakoc was awarded The Paul Marks Prize for Cancer Research for his ongoing contributions to the understanding of cancer. Read the story »
14th annual Double Helix Medals dinner raises over $4 million
News
CSHL’s 2019 Double Helix Medals dinner honored the contributions of Dr. Nancy Wexler and Boomer Esiason. Read the story »
A home like no other, Cold Spring Harbor Laboratory
Hear why our campus, our community, and our collaborative nature makes us a place that so many scientists call "home." Watch the video »
Nancy Wexler, 2019 Double Helix Medal Recipient
For her contributions to basic research, Nancy Wexler was awarded a Double Helix Medal from Cold Spring Harbor Laboratory in 2019. Watch the video »
Scientists take action to prevent sexual harassment and bias
News
Scientists gathered at Banbury Center last year to discuss ways to prevent gender bias and sexual harassment in science. Read the story »
Boomer Esiason, 2019 Double Helix Medal Recipient
Cold Spring Harbor Laboratory awards Boomer Esiason a Double Helix Medal in 2019. Watch the video »
These tomatos flourish in a storage unit
Before now, Urban Agriculture has been dominated by compact, leafy greens such as lettuce growing in climate-controlled storage units. Watch the video »
High school senior wins big in Breakthrough Junior Challenge
News
Winning the 2019 Breakthrough Junior Challenge, student Jeffery Chen earned his high school a $100,000 science lab designed by the DNA Learning Center. Read the story »
Plant scientist David Jackson–A CSHL PI profile
CSHL Professor David Jackson studies mutated corn and flowers. Watch the video »
Historic lab at CSHL transformed for future cancer research
News
NY Governor Andrew Cuomo cut the ribbon for CSHL’s renovated Demerec lab space, marking the beginning of a new chapter for the historied building. Read the story »
CSHL named Top Long Island Workplace for second year
News
CSHL is named a Top Long Island Workplace by Newsday for the second year in a row. Read the story »
Researchers double sorghum grain number to improve food supply
News
A set of hormone-controlling genes may be the key to doubling grain number in sorghum plants. Read the story »
CSHL postdocs receive NARSAD Young Investigator Grants
News
Two CSHL neuroscience postdocs conducting neurobiological and psychiatric research received the 2019 NARSAD Young Investigators grant. Read the story »
The important role of an Uplands Farm cat
Blog
Cats, Uplands Farm’s smallest employees, have always played a big role in plant care and seed guarding. Read the story »
Nobel laureate William Kaelin draws a crowd
Blog
Nobel laureate and cancer researcher William Kaelin holds a seminar on his award-winning research at CSHL. Read the story »
Seeking better treatment for ALS, Lou Gehrig’s disease
News
Researchers found that ‘jumping genes’ were de-silenced in post-mortem tissue samples of ALS patients. Read the story »
Historic building—groundbreaking science
Feature
The Demerec building has been monumental in scientific history. Now, a $75 million renovation of this celebrated labspace will define CSHL’s future. Read the story »
One experiment: The shape of norovirus
Feature
Scientists at CSHL examine the structure of a norovirus under the cryo-electron microscope. Read the story »
Adrian Krainer elected to National Academy of Medicine
News
Professor Adrian Krainer joins the National Academy of Medicine in honor of his groundbreaking work on SMA. Read the story »
Learning about organoids at the CSHL Open House
Research Investigator Lindsey Baker, Ph.D., co-developed the organoid system for pancreatic cancer. In this video, she explains how it works. Watch the video »
BARseq builds a better brain map
News
Created by CSHL neuroscientists, BARseq is capable of mapping connections within a brain at single-neuron resolution while tracing their gene expression. Read the story »
Effective vaccines for Lyme disease are needed
News
A new report reiterates the need to stop Lyme disease and defines a strategy for developing effective vaccines against it. Read the story »
New brain research could change how concussions are treated
News
Blood vessel damage seems to be more widespread than nerve damage in patients with traumatic brain injuries. Read the story »
A new way to look at cancer with Tobias Janowitz—A Cocktails and Chromosomes talk
Given the errors that happen every time our cells divide, why don’t we get cancer all the time? Dr. Janowitz explained that and more over a beer. Watch the video »
Adrian Krainer wins Zülch Prize for lifesaving SMA Treatment
News
Professor Adrian Krainer is awarded the K-J. Zülch Prize for the development and testing of a first-of-its-kind treatment for spinal muscular atrophy. Read the story »
How Henri Termeer built a biotech giant
News
In a new biography out from CSHL Press, John Hawkins documents Henri Termeer’s legacy in biotechnology. Read the story »
Mutant cells team up to make an even deadlier blood cancer
News
Two very different mutations have been identified as unexpected partners-in-crime for causing the deadly blood cancer acute myeloid leukemia. Read the story »
Transparent review in preprints
News
Transparent Review in Preprints (TRiP) enables journals and peer review services to post peer reviews of manuscripts on CSHL’s preprint server bioRxiv. Read the story »
How to build more trust in science
News
Some of the world’s leading custodians of scientific research integrity met at CSHL’s Banbury Center to find out new ways to build trust in science. Read the story »
Coffee day quiz
Did you know that caffeine is a drug? On international coffee day, explore the chemistry of the infamous drink with our short science quiz. Take the quiz »
Discovery could improve MDS cancer treatment
News
Researchers have discovered a promising new target for treating myelodysplastic syndrome (MDS), a common and lethal blood cancer. Read the story »
Zachary Lippman named 2019 MacArthur Fellow
News
Cold Spring Harbor Laboratory Professor and HHMI Investigator Zachary Lippman has been named a 2019 MacArthur Fellow. Read the story »
Mice, like humans, fidget when deep in thought
News
Mice seemed to fidget while making decisions, prompting neuroscientists to think more about the connection between movement and cognition. Read the story »
Peter Koo wants to understand how machines learn biology
News
Dr. Peter Koo joins the CSHL faculty as an assistant professor. His focus is on exploring how artificial intelligence integrates with biology and genomics. Read the story »
Quiz gone viral
Since the Hershey and Chase experiment, scientists have expanded their understanding of viruses. Measure your viral knowledge with our science quiz! Take the quiz »
The next agricultural revolution is here
News
After reviewing decades of plant research, scientists suggest that with past lessons and modern tools, the next agricultural revolution is at hand. Read the story »
The world of Brianna Bibel, The Bumbling Biochemist
Blog
Brianna Bibel, a third-year graduate student at WSBS, is making ripples in the science community through her social media presence. Read the story »
How one family secured the future of a laboratory
Feature
The Robertson family gifts to CSHL in the early 1970s were of extraordinary importance, for without them the Laboratory might not have survived. Read the story »
Cancer drugs don’t always work as intended, researchers warn
News
Ten experimental cancer drugs kill tumors in ways that are entirely different than how clinicians thought they did, revealing important insights. Read the story »
Overcoming resistance in pancreatic cancer
News
Controlling pancreatic tumor proliferation by targeting malignancy-specific resistance pathways in response to AKT and MAPK blockade. Read the story »
Remembering David Koch
News
CSHL Board of Trustees, faculty and administration mourn the passing of David H. Koch, a supporter of cancer researcher. Read the story »
Are smart robots a threat?
News
In a Q&A, Neuroscientist Anthony Zador explains how neuroscience can inform machine learning, and why he’s not worried about a robot apocalypse. Read the story »
Understanding the animal brain could help robots wash your dishes
News
The field of machine learning still has a lot it can glean from neuroscience, especially in how evolution shapes an animal brain. Read the story »
New brain map could improve AI algorithms for machine vision
News
A revised view of the primate visual system may serve as a future reference for understanding how vision works in humans. Read the story »
CSHL graduate student wins HHMI fellowship
News
WSBS student David Johnson won a 2019 Gilliam Fellowships for Advanced Study for leadership and diversity in science. Read the story »
How a lab and its model animals changed science
Feature
The natural history of science at Cold Spring Harbor Laboratory through the lens of animal research. Read the story »
Understanding pregnancy’s effects on breast cancer risk
News
CSHL researchers authored a review in the journal Cell covering the landscape of breast cancer research. Read the story »
A survivor’s path to cancer research
Blog
Leukemia survivor and CSHL volunteer Anya Shah talks about her drive to do cancer research and her time in Vakoc lab. Read the story »
Creature feature quiz
Animals have been the muses behind major scientific breakthroughs for ages. See how much you know about the living organisms sharing the Earth with us. Take the quiz »
Of mice and model organisms
Feature
An in-depth look at how veterinarians at CSHL help take care of the various organisms that help researchers answer fundamental biological questions. Read the story »
Urban Barcode Project showcases student research in biodiversity
News
The eighth annual Urban Barcode Project Symposium had young scientists measuring the biodiversity of New York City. Read the story »
There’s more to smell than meets the nose
Feature
Neuroscience researchers work to figure out our brains process smells, including what features are essential to identifying and separating odors. Read the story »
Quantifying how the brain smells
News
Neuroscience researchers at CSHL are trying to figure out how the brain processes smells and what features of odors are important in that process. Read the story »
Discussing breast cancer with Camila dos Santos—A Cocktails and Chromosomes talk
Women who have their 1st child before age 25 are less likely to develop breast cancer later in life. Why? Dr dos Santos discusses finding the answer. Watch the video »
Sheltzer wins Presidential Early Career Award
News
CSHL Fellow Jason Sheltzer is a recipient of the Presidential Early Career Award for Scientists and Engineers for his work in cancer research. Read the story »
Laura Slatkin elected to CSHL Board of Trustees
News
Co-founder of NEXT for AUTISM Laura Slatkin joins the Cold Spring Harbor Laboratory Board of Trustees. Read the story »
Cancer cells’ “self eating” may be new drug target
Researchers reveal how pancreatic cancer cells adapt to the low energy environment of a tumor. Watch the video »
Cancer cell’s “self eating” tactic may be its weakness
News
Pancreatic cancer cells are eating their own mitochondria to survive and spread. New research reveals how, hinting at a possible new drug target. Read the story »
Diet and Disease
Are you what you eat? Two experts explain how nutrition can influence how your body responds to a range of cancer and other illness. Watch the video »
CSHL ranked #1 in research output worldwide
News
The scientific journal Nature named Cold Spring Harbor Laboratory as the top academic research institution in its annual index. Read the story »
Lee awarded Chan Zuckerberg Initiative Human Cell Atlas grant
News
Assistant Professor Je H. Lee has been named a recipient of one of the Seed Networks for the Human Cell Atlas to study breast tissue. Read the story »
Sugars that coat proteins are a possible drug target for pancreatitis
News
CA19-9, a complex sugar structure coating proteins, represents a possible drug target for treatment of pancreatitis and prevention of pancreatic cancer. Read the story »
Can these sugars serve as a possible drug target for pancreatitis?
CSHL Tuveson lab member Dani Engle explains how sugars serve as a possible drug target for pancreatitis. Watch the video »
2019 CSHL Open House was a hit!
News
Over 650 neighbors and science enthusiasts visited the 2019 Open House at CSHL. Read the story »
Special fibroblasts help pancreatic cancer cells evade immune detection
News
Researchers found a specific type of cancer-associated fibroblast interacts with the immune system to help pancreatic cancer cells stay under the radar. Read the story »
Cryo-EM illuminates intricate designs of noroviruses
Feature
Researchers reconstruct four different strains of the food-poisoning causing norovirus using the groundbreaking cryo-electron microscope. Read the story »
Norovirus structures could help develop treatments for food poisoning
News
Researchers at CSHL used cryo-EM to reconstruct the structures of four different strains of human noroviruses, which cause food poisoning. Read the story »
Fighting cancer in 3D
News
David Tuveson, Director of the CSHL Cancer Center, shares insights about his work on organoid technology. Read the story »
New preprint server for the health sciences announced today
News
CSHL, Yale University, and BMJ launch medRxiv, a free preprint service for the medical and health sciences. Read the story »
Plan Universal calls on funders to encourage preprints
News
bioRxiv founders propose new plan to encourage organizations to make research readily available via preprint servers. Read the story »
Interview with a neuroscientist
Feature
CSHL Professor Bo Li’s lab studies the biology behind mental disorders. Learn more about how Li’s work is changing the way we think about mental health. Read the story »
Building a song: A look at CSHL’s Choir
Hard practice pays off. CSHL’s choir performs the WSBS alma mater, while we look at the community they’ve built around music. Watch the video »
Hitting the high notes at the Lab
Blog
The CSHL choir is a cherished tradition, bringing song to some of the Lab’s most important occasions. Learn more about the history of this storied group. Read the story »
CSHL celebrates 20 years of graduate school at 2019 commencement
News
The Watson School of Biological Sciences held its 16th commencement, with seven researchers graduating with doctoral degrees. Read the story »
Leading discovery
Feature
Current discoveries about DNA and human genome position CSHL scientists to make life-changing breakthroughs that will improve the human condition. Read the story »
Honorary degrees to former CSHL leaders
News
From pioneering eukaryotic gene regulation to directing cancer research, here are the alumni being awarded honorary Doctor of Science degrees. Read the story »
Watson School alumni spotlights
News
This year, Watson School celebrates the 20th anniversary of its first entering class and looks back at some notable alumni from over the years. Read the story »
Watson School 2019 Ph.D.s
News
Seven students were awarded Ph.D. degrees from Watson School this May. Here, they reflect on their time at the Laboratory as they look to the future. Read the story »
An essay from the President: Biology for the planet
Feature
CSHL plant scientists are looking for solutions to the biggest questions in agriculture as environments are reshaped by climate change. Read the story »
Enzyme PHLPP2 could be a viable drug target for treating prostate cancer
News
Researchers have identified an enzyme called Phlpp2 as an attractive drug target for treating prostate cancer. Read the story »
Remembering John Cairns, CSHL Director, 1963-1968
News
CSHL celebrates the achievements of the late Dr. John Cairns, lab director from 1963 to 1968. Read the story »
Profile: Doreen Ware champions the plant genome
Feature
Molecular biologist Doreen Ware uses computer science to parse out the genetic roadmaps of plants. Read the story »
Cryptic mutation is cautionary tale for crop gene editing
Feature
Unexpected interactions between mutations can be a thorn in the side for plant breeders. Scientists unveil what drove one infamous “cryptic” mutation. Read the story »
How do plants sense their environment?
CSHL plant scientist Ullas Pedmale details how plants sense the world we share. Watch the video »
Andrea Schorn zooms in on small RNAs in the cell
News
Dr. Andrea Schorn joins CSHL faculty as research assistant professor. Her focus is exploring transposable elements in the genome of mammalian cells. Read the story »
DNA and pop culture quiz
When artistic expression meets gene expression, how well does art imitate life? Take our five-question science IQ quiz to find out. Take the quiz »
Seeing with sequencing—A public lecture with three CSHL experts
Quantitative biologists discuss how physics, modern computing power, and a new perspective on biology can make sense of our complex genomes. Watch the video »
Cold Spring Harbor Laboratory announces exclusive license with plant breeding start-up Inari
News
CSHL announced a licensing agreement with partner Inari, a company that is advancing plant breeding by tapping nature’s genetic diversity. Read the story »
Rob Martienssen wins Martin Gibbs Medal for plant research
News
CSHL Professor Rob Martienssen wins the 2019 Martin Gibbs Medal for his contributions to plant biology. Read the story »
To protect stem cells, plants have diverse genetic backup plans
News
Experts discover how an essential genetic circuit found in all flowering plants, regardless of species, is protected in startlingly different ways. Read the story »
NIH grant awarded for interneuron research
News
CSHL postdoc Maggie Crow will use her NIH grant to pursue the quantification and analysis of specific types of neurons in the brain. Read the story »
President Bruce Stillman wins prestigious Gairdner Award
News
Dr. Bruce Stillman, President & CEO of CSHL, has been awarded the 2019 Canada Gairdner International Award for his work on eukaryotic DNA replication. Read the story »
Crop yield in maize influenced by unexpected gene ‘moonlighting’
News
Yield of the maize plant is tied to activity of a gene called RAMOSA3, but new evidence suggests the gene performs other unexpected functions Read the story »
Hannah Meyer joins CSHL Quantitative Biology faculty
News
Hannah Meyer is the newest Quantitative Biology Fellow at CSHL, studying how our immune system learns to identify and fight pathogens. Read the story »
CSHL President elected as AACR Academy Fellow
News
CSHL President and CEO Dr. Bruce Stillman has been elected to the AACR Academy as part of the 2019 Fellows class. Read the story »
One experiment: Observing cancer’s progress in a mouse prostate
Feature
Using a technique originally designed for mapping brains, two CSHL labs have worked together to image cancer progression in a mouse prostate. Read the story »
Banbury meeting addresses neurotechnology concerns
News
A white paper written after an important Banbury Center meeting discusses the lack of oversight in direct-to-consumer neurotechnologies. Read the story »
New cell subtypes classified in mouse brain
News
To map a brain, an intuitive system for classifying neuron types is necessary. Now, a promising approach reveals new cell subtypes in the mouse brain. Read the story »
Adrian Krainer wins RNA Society’s Lifetime Achievement Award
News
Professor Adrian Krainer was awarded the RNA Society’s Lifetime Achievement Award for his life-saving research. Read the story »
Congressman Suozzi congratulates CSHL Partner for the Future
News
Partner for the Future Pragati Muthukumar received a special commendation from Congressman Tom Suozzi. Read the story »
Genetic ‘usual suspects’ identified in researchers’ new list
News
An exhaustive ranked list of “usual suspect” genes involved in disease may prove invaluable for future research and drug discovery. Read the story »
Chandelier neuron requires ‘Velcro-like’ molecule to form connections
News
How do brain cells network? Researchers have discovered an essential ingredient that facilitates one type of neuron’s many neighborly connections. Read the story »
Detailed new primate brain atlas could lead to disease insights
News
An international effort has mapped the marmoset brain at an unprecedented level of detail, which brings us closer to understanding the human brain. Read the story »
Science is a lesson in ‘eye-opening’ for students and teachers
Blog
WSBS graduate student Bruno Gegenhuber embraced teaching at the DNA Learning Center as a learning experience in itself. Read the story »
What does sight mean to a cancer researcher?
Blog
Postdoc Leah Banks discusses vision’s role in cancer research, and how nearly losing her sight gave her a new perspective on her work. Read the story »
David McCandlish named Sloan Research Fellow
News
Assistant Professor David McCandlish has been named a 2019 Sloan Research Fellow for his promising work in the field of quantitative biology. Read the story »
bioRxiv surpasses one million monthly downloads
News
A recent study illustrates the success of bioRxiv, CSHL’s biology preprint server. Read the story »
Christina Renna Foundation gives $35k for pediatric cancer research
News
The Christina Renna Foundation donated $35,000 to CSHL for continued work on Sarcoma Research Project and research into RMS. Read the story »
CSHL Scientific Advisory Council member wins Vilcek Prize
News
Dr. Angelika Amon, a member of the CSHL Scientific Advisory Council, wins the Vilcek Foundation Prize for her important work in cell biology. Read the story »
How does math help us understand the brain?
Feature
An exploration of how computational neuroscientist Tatiana Engel uses math to understand how the brain makes decisions. Read the story »
CSHL Fellow Jason Sheltzer wins innovation award
News
CSHL Fellow Jason Sheltzer wins the Damon Runyon-Rachleff Innovation Award for his work on cancer. Read the story »
CSHL Scientific Advisory Council member wins NAS honor
News
Dr. Eve Marder of the CSHL Scientific Advisory Council wins the National Academy of Sciences Award in the Neurosciences. Read the story »
Rob Martienssen special talk: Barbara McClintock’s Controlling Elements, Then and Now
Rob Martienssen's special lecture on Barbara McClintock's 'Controlling Elements, Then and Now,' given at the CSHL Library Szybalski Reading Room. Watch the video »
Rethinking cancer medicine
Tobias Janowitz, M.D., Ph.D. presents “how tumors interact with the entire body” and how understanding this, leads to “the questions that matter.” Watch the video »
CSHL donates sheets to veterans in need
News
CSHL donated 75 bags of sheets to the United Veterans Beacon House, with the aid of the Lindenhurst Rotary Club and the Christina Renna Foundation. Read the story »
Targeting ‘hidden pocket’ for treatment of stroke and seizure
News
Researchers have identified a hidden molecular “pocket” in a special neuron receptor, which could lead to better treatments for stroke and seizures. Read the story »
Austin’s Purpose donates $10k to neuroscience research
News
Epilepsy research-supporting organization Austin’s Purpose makes a donation to continue key neuroscience research in Professor Hiro Furukawa’s lab. Read the story »
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