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The immune system, unleashed

May 15th, 2018

Feature
Research

Cancer immunotherapy has a long and storied history, one that begins with a young woman suffering from a pain in her hand...

The immune system, unleashed

Nature’s masterpiece: the brain

May 11th, 2018

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Institutional

A message from President and CEO Dr. Bruce Stillman from the Spring 2018 Harbor Transcript on the innovative research happening at CSHL...

Nature’s masterpiece: the brain

Bringing immune cells back into the cancer fight

May 4th, 2018

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Research

Doug Fearon used a mouse model to discover how pancreatic cancer hides from the immune system...

Bringing immune cells back into the cancer fight

Portrait of a Neuroscience Powerhouse

April 27th, 2018

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Research

A relatively small neuroscience group at CSHL is having an outsized impact on a dynamic and highly competitive field...

Portrait of a Neuroscience Powerhouse

Research profile: Robert Maki

April 2nd, 2018

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Research

Straddling CSHL and Northwell Health gives Dr. Maki the perspective he needs to bring cancer research closer to the practice of treating patients...

Research profile: Robert Maki

The course to science stardom

April 2nd, 2018

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Education

At least 10 CSHL Courses alumni have gone on to win a Nobel Prize, while others have become leaders of major scientific institutions...

The course to science stardom

One experiment: Twice the tomatoes

March 22nd, 2018

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Research

Zachary Lippman’s team found a way to boost tomato yield by digging into the plant’s genome and fine-tuning its branching patterns....

One experiment: Twice the tomatoes

The cancer answer that wasn’t

March 15th, 2018

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Research

We look at the "reproducibility crisis" in science, with a cancer researcher discovering something he didn't expect while experimenting with MELK...

The cancer answer that wasn’t

One experiment: When cancer is hiding in plain sight

March 1st, 2018

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Research

Douglas Fearon's team is figuring out how to get immune cells to recognize—and kill—pancreatic cancer cells...

One experiment: When cancer is hiding in plain sight

A lesson in class

December 15th, 2017

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Research

In this episode of Base Pairs, we discuss how genetic information is changing how we define important categories....

A lesson in class

Research profile: Leemor Joshua-Tor

November 27th, 2017

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Research

A CSHL faculty member since 1995, a professor since 2005, Joshua-Tor is among the most distinguished members of the Laboratory community....

Research profile: Leemor Joshua-Tor

Next-gen cancer test

November 24th, 2017

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Research

Knowing that cancers become lethal when they spread, investigators at Cold Spring Harbor Laboratory seek a way of detecting tumors much earlier ...

Next-gen cancer test

One experiment: A beautiful brain, neuron by neuron

November 22nd, 2017

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Research

Associate Professor Pavel Osten and colleagues discovered using their qBrain method is discerned by probing hidden relations among the dots....

One experiment: A beautiful brain, neuron by neuron

Double Helix Medals dinner

November 21st, 2017

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Institutional

The 2017 Double Helix Medals were presented to Tom Brokaw and Helen Ann and Charles Dolan....

Double Helix Medals dinner

Big decisions

November 15th, 2017

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Research

David Micklos of the DNA Learning Center, and Miriam Rich, a research scholar, talk about the big issues of eugenics....

Big decisions

One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells

October 19th, 2017

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Research

Associate Professor Mikala Egeblad discovers that neutrophil extracellular traps (NETs) help cancer by creating holes in the tissue....

One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells

Good genes, bad science

October 15th, 2017

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Research

On this episode, Base Pairs looks into the eugenics movement, including the record kept in CSHL....

Good genes, bad science

Do neuroscientists need to switch gears to understand how brains make choices?

October 2nd, 2017

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Research

Associate Professor Anne Churchland, co-founder the IBL along with Professor Tony Zador, explains how it could help solve a problem in neuroscience....

Do neuroscientists need to switch gears to understand how brains make choices?

What Silicon Valley and biology research share

September 15th, 2017

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Research

Further discussion with Associate Professor Gurinder "Mickey" Atwal about the need for more math and physics in biology....

What Silicon Valley and biology research share

Biology, behind the screens

August 15th, 2017

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Research

Associate Professor Gurinder "Mickey" Atwal talks about the essential mystery at the center of quantitative biology....

Biology, behind the screens

Tomato baby and its family

July 14th, 2017

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Research

This episode of Base Pairs talks to Associate Professor Zachary Lippman about all the weird mutations that naturally occur in plants....

Tomato baby and its family

CRISPR vs. climate change

June 15th, 2017

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Research

This episode of Base Pairs looks at the issues climate change may bring to agriculture and how CRISPR can help overcome them....

CRISPR vs. climate change

Redefining biologists, redefining genes

May 16th, 2017

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Research

Drs. Molly Hammell and Thomas Gingeras talk about redefining what a biologist is and what genes are....

Redefining biologists, redefining genes

Dark matter of the genome, part 2

April 15th, 2017

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Research

This episode of Base Pairs deals with the myth of "junk DNA" and why scientists are interested in non-coding portions of the genome....

Dark matter of the genome, part 2

Dark matter of the genome, part 1

March 15th, 2017

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Research

This episode of Base Pairs digs into "dark matter" a type of genetic information that could help scientists better understand diseases like...

Dark matter of the genome, part 1

Molecules and a mission

January 27th, 2017

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Research

A special bonus episode of Base Pairs offering an explanation of why the name "Base Pairs" was chosen...

Molecules and a mission

The brain atlas

December 14th, 2016

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Research

This episode of BasePairs looks at the problems of neuropsychiatric drug discovery, and the method by which they may soon be resolved....

The brain atlas

One experiment: A drug for SMA visibly repairs defective cells

December 1st, 2016

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Research

Professor Adrian Krainer develops a treatment for spinal muscular atrophy, the leading genetic cause of infant death....

One experiment: A drug for SMA visibly repairs defective cells

When antioxidants are pro-cancer

November 15th, 2016

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Research

For Pancreatic Cancer Awareness Month, Base Pairs looks at the science of antioxidants and cancer....

When antioxidants are pro-cancer

“Sink or swim”

October 15th, 2016

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Research

This episode of Base Pairs follows Professor Adrian Krainer and his experience as the first CSHL fellow....

“Sink or swim”

The people problem

September 15th, 2016

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Research

This episode of Base Pairs looks at the rising population, plant biology, and the future of food....

The people problem

Non-modern family

August 15th, 2016

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Education Research

This episode on Base Pairs explores how genetic information to better understand human history....

Non-modern family

Corn controversy

July 15th, 2016

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Research

This episode of Base Pairs covers the contentious genetics and history of America’s corn production....

Corn controversy

One experiment: How the breast “remembers” a first pregnancy

July 2nd, 2016

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Research

Professor Greg Hannon and his team, including Assistant Professor Camila dos Santos, learn more about breast cells and tissue....

One experiment: How the breast “remembers” a first pregnancy

From phages to faces

June 15th, 2016

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Research

In the pilot episode of Base Pairs, two stories of DNA research that show how far the field has come...

From phages to faces

One experiment: Cellular highways carry anti-cancer cargoes

April 9th, 2015

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Research

The gene called PTEN is one of the most important of the body’s natural tumor suppressors....

One experiment: Cellular highways carry anti-cancer cargoes

One experiment: McClintock’s historic discovery

December 1st, 2014

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Research

Four decades after this photo was taken, a Nobel Prize was awarded to McClintock, acknowledging her discovery that genetic material is not fixed...

One experiment: McClintock’s historic discovery

One experiment: Sometimes our cells express only one gene copy. Why?

June 1st, 2014

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Research

Professor David L. Spector and team discover some monoallelically expressed genes encoded extra RNA, even though they are missing their other gene....

One experiment: Sometimes our cells express only one gene copy. Why?