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Doreen Ware

Doreen Ware

Adjunct Associate Professor

Ph.D., Ohio State University, 2000

ware@cshl.edu | (516) 367-6979

Ware Lab

When we think of evolution, we often think about physical changes, like a plant developing broader leaves to collect more solar energy. Such evolution actually occurs within the plant’s DNA. I am using computational analysis and modeling to visualize how plant genomes have evolved over time, particularly those of staple crops. We are learning from this work to improve the range and yield of modern plants.

Using multidisciplinary approaches that combine computational analysis, modeling, and prediction with experimental verification, Doreen Ware’s lab seeks a deeper understanding of the evolution of genome sequences in plants and their implications for agricultural improvement. By looking comparatively across the genomes of plants in the same lineage, they seek answers to the following questions: How are genes conserved and lost over time? What are the fates of duplicated genes? What is the impact of structural variation on phenotypic variation? Ware’s team also studies gene regulation in plants, focusing on gene regulatory networks, targeting transcription factors and microRNA genes with the objective of understanding how these parts of the plant genome work together in determining spatial and temporal expression of genes. The lab had an important role in the project to produce a haplotype map reference genome of maize, spearheading the most comprehensive analysis of the crop yet. This has provided important information on the variation of the reference genome, as well as comparative data showing changes in the genome acquired through domestication and breeding. They have devoted special attention to examining diversity within maize, grape, and tomato, aiming to accelerate the development of strategies to introduce new germplasm that is needed to meet demands of increasing population and a changing environment. The lab also has brought fully sequenced genomes into an integrated data framework, to enhance the power of their comparative studies. This past year, Ware was named as its principal investigator for the National Science Foundation-funded Gramene project, a comparative genomics resource for agriculturally important crops and models to support sustainable food and fuel production. Ware, as principal investigator for plants, has also helped lead an effort funded by the Department of Energy to create—out of many separate streams of biological information—a single, integrated cyber-“knowledgebase” for plants and microbial life.

    The secret to tripling the number of grains in sorghum and perhaps other staple crops

    The secret to tripling the number of grains in sorghum and perhaps other staple crops

    February 26, 2018

    Cold Spring Harbor, NY — A simple genetic modification can triple the grain number of sorghum, a drought-tolerant plant that is an important source of food, animal feed, and biofuel in many parts of the world. In new research reported today in Nature Communications, scientists at Cold Spring Harbor Laboratory (CSHL) have figured out how...


    More rice, please: 13 rice genomes reveal ways to keep up with ever-growing population

    More rice, please: 13 rice genomes reveal ways to keep up with ever-growing population

    February 1, 2018

    Cold Spring Harbor, NY — Billions of people around the world rely on rice as a mainstay of their diet. The grain provides about 20 percent of the calories consumed by humans worldwide. Rice production is critical for global food security, and demand will only grow as the world’s population expands by an estimated 2-3...


    Public Lecture: THE CHANGING RELATIONSHIP BETWEEN HUMANS AND PLANTS – “It’s complicated”

    Public Lecture: THE CHANGING RELATIONSHIP BETWEEN HUMANS AND PLANTS – “It’s complicated”

    September 8, 2017

    THE CHANGING RELATIONSHIP BETWEEN HUMANS AND PLANTS: ✓ It’s complicated David Jackson, Ph.D. – Professor, CSHL Zachary Lippman, Ph.D. – Professor, CSHL Doreen Ware, Ph.D. – Adjunct Associate Professor, CSHL & USDA Agricultural Research Service RSVP HERE


    Doreen Ware

    Doreen Ware

    August 13, 2017


    Detailed new ‘reference’ genome for maize shows the plant has deep resources for continued adaptation

    Detailed new ‘reference’ genome for maize shows the plant has deep resources for continued adaptation

    June 12, 2017

    ‘Phenotypic plasticity’ traced to maize’s regulatory flexibility bodes well for expanding the staple’s growing range as the planet warms Cold Spring Harbor, NY — A new, much more detailed reference genome for maize, or corn, as it is called in the U.S., will be published in Nature today. In its accounting of the sequence of DNA letters in...


    “Amazing protein diversity” is discovered in the maize plant

    “Amazing protein diversity” is discovered in the maize plant

    June 24, 2016

    Cold Spring Harbor, NY — The genome of the corn plant—or maize, as it’s called almost everywhere except the US—“is a lot more exciting” than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant’s genetic resources. “Our new research establishes the amazing...


    The iPlant Collaborative is now called CyVerse

    The iPlant Collaborative is now called CyVerse

    January 15, 2016

    The enhanced NSF project will now provide data management and computation across scientific disciplines Cold Spring Harbor, NY — The iPlant Collaborative is now called CyVerse.  The advanced data management platform for the life sciences, funded by the National Science Foundation (NSF), announced the change on January 8th.  The collaborative includes the University of Arizona,...


    CSHL is part of iPlant group awarded $50 million to create US biology cyberinfrastructure

    CSHL is part of iPlant group awarded $50 million to create US biology cyberinfrastructure

    September 17, 2013

    Cold Spring Harbor, NY — The National Science Foundation (NSF) has awarded $50 million to investigators at Cold Spring Harbor Laboratory (CSHL) and other members of the multi-institution iPlant collaborative headquartered at the University of Arizona’s BIO5 Institute to create a national cyberinfrastructure for the biological sciences. “The renewal grant for the iPlant Collaborative will...


    Two pioneering plant genomics efforts given a funding boost by National Science Foundation

    Two pioneering plant genomics efforts given a funding boost by National Science Foundation

    September 5, 2012

    Cold Spring Harbor, NY — With research in plant biology “at a tipping point,” in the words of a leading investigator, two pathbreaking efforts by scientists interested in making comparisons across and within sequenced plant genomes have been given a significant funding boost and vote of confidence from the National Science Foundation (NSF). The NSF...


    ‘Most comprehensive’ genetic analysis of maize plant will help raise yields, expand its range

    ‘Most comprehensive’ genetic analysis of maize plant will help raise yields, expand its range

    June 1, 2012

    Cold Spring Harbor, NY and Washington, DC — An international  research team involving 17 institutions including Cold Spring Harbor Laboratory has published the most comprehensive analysis to date of the maize genome.  It is an achievement that substantially increases scientists’ understanding of differences across related but different species of the plant, which most North Americans call...


Liu, Z. J. and Kumari, S. and Zhang, L. F. and Zheng, Y. L. and Ware, D. (2012) Characterization of miRNAs in Response to Short-Term Waterlogging in Three Inbred Lines of Zea mays. PLoS ONE, 7(6) pp. e39786.

Chia, J. M. and Song, C. and Bradbury, P. J. and Costich, D. and de Leon, N. and Doebley, J. and Elshire, R. J. and Gaut, B. and Geller, L. and Glaubitz, J. C. and Gore, M. and Guill, K. E. and Holland, J. and Hufford, M. B. and Lai, J. and Li, M. and Liu, X. and Lu, Y. and McCombie, R. and Nelson, R. and Poland, J. and Prasanna, B. M. and Pyhajarvi, T. and Rong, T. and Sekhon, R. S. and Sun, Q. and Tenaillon, M. I. and Tian, F. and Wang, J. and Xu, X. and Zhang, Z. and Kaeppler, S. M. and Ross-Ibarra, J. and McMullen, M. D. and Buckler, E. S. and Zhang, G. and Xu, Y. and Ware, D. (2012) Maize HapMap2 identifies extant variation from a genome in flux. Nat Genet, 44(7) pp. 803-U238.

Brady, S. M. and Zhang, L. and Megraw, M. and Martinez, N. J. and Jiang, E. and Yi, C. S. and Liu, W. and Zeng, A. and Taylor-Teeples, M. and Kim, D. and Ahnert, S. and Ohler, U. and Ware, D. H. and Walhout, A. J. M. and Benfey, P. N. (2011) A stele-enriched gene regulatory network in the Arabidopsis root. Molecular Systems Biology, 7 pp. 459.

Youens-Clark, K. and Buckler, E. and Casstevens, T. and Chen, C. and DeClerck, G. and Derwent, P. and Dharmawardhana, P. and Jaiswal, P. and Kersey, P. and Karthikeyan, A. S. and Lu, J. and McCouch, S. R. and Ren, L. and Spooner, W. and Stein, J. C. and Thomason, J. and Wei, S. and Ware, D. H. (2011) Gramene database in 2010: Updates and extensions. Nucleic Acids Research, 39(SUPPL.)

Paterson, A. H. and Bowers, J. E. and Bruggmann, R. and Dubchak, I. and Grimwood, J. and Gundlach, H. and Haberer, G. and Hellsten, U. and Mitros, T. and Poliakov, A. and Schmutz, J. and Spannagl, M. and Tang, H. and Wang, X. and Wicker, T. and Bharti, A. K. and Chapman, J. and Feltus, F. A. and Gowik, U. and Grigoriev, I. V. and Lyons, E. and Maher, C. A. and Martis, M. and Narechania, A. and Otillar, R. P. and Penning, B. W. and Salamov, A. A. and Wang, Y. and Zhang, L. and Carpita, N. C. and Freeling, M. and Gingle, A. R. and Hash, C. T. and Keller, B. and Klein, P. and Kresovich, S. and McCann, M. C. and Ming, R. and Peterson, D. G. and Mehboob ur, R. and Ware, D. H. and Westhoff, P. and Mayer, K. F. X. and Messing, J. and Rokhsar, D. S. (2009) The Sorghum bicolor genome and the diversification of grasses. Nature, 457(7229) pp. 551-556.

Additional materials of the author at
CSHL Institutional Repository