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Doreen Ware

Doreen Ware

Adjunct Professor

Ph.D., Ohio State University, 2000

ware@cshl.edu | 516-367-6979

Ware Lab Website   Faculty Profile

When we think of evolution, we often think about physical changes, like a plant developing broader leaves to collect more solar energy. Such evolution actually occurs within the plant’s DNA. I am using computational analysis and modeling to visualize how plant genomes have evolved over time, particularly those of staple crops. We are learning from this work to improve the range and yield of modern plants.

Using multidisciplinary approaches that combine computational analysis, modeling, and prediction with experimental verification, Doreen Ware’s lab seeks a deeper understanding of the evolution of genome sequences in plants and their implications for agricultural improvement. By looking comparatively across the genomes of plants in the same lineage, they seek answers to the following questions: How are genes conserved and lost over time? What are the fates of duplicated genes? What is the impact of structural variation on phenotypic variation? Ware’s team also studies gene regulation in plants, focusing on gene regulatory networks, targeting transcription factors and microRNA genes with the objective of understanding how these parts of the plant genome work together in determining spatial and temporal expression of genes. The lab had an important role in the project to produce a haplotype map reference genome of maize, spearheading the most comprehensive analysis of the crop yet. This has provided important information on the variation of the reference genome, as well as comparative data showing changes in the genome acquired through domestication and breeding. They have devoted special attention to examining diversity within maize, grape, and tomato, aiming to accelerate the development of strategies to introduce new germplasm that is needed to meet demands of increasing population and a changing environment. The lab also has brought fully sequenced genomes into an integrated data framework, to enhance the power of their comparative studies. This past year, Ware was named as its principal investigator for the National Science Foundation-funded Gramene project, a comparative genomics resource for agriculturally important crops and models to support sustainable food and fuel production. Ware, as principal investigator for plants, has also helped lead an effort funded by the Department of Energy to create—out of many separate streams of biological information—a single, integrated cyber-“knowledgebase” for plants and microbial life.

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All Publications

A high-performance computational workflow to accelerate GATK SNP detection across a 25-genome dataset

25 Jan 2024 | BMC Biology | 22(1):13
Zhou, Yong, Kathiresan, Nagarajan, Yu, Zhichao, Rivera, Luis, Yang, Yujian, Thimma, Manjula, Manickam, Keerthana, Chebotarov, Dmytro, Mauleon, Ramil, Chougule, Kapeel, Wei, Sharon, Gao, Tingting, Green, Carl, Zuccolo, Andrea, Xie, Weibo, Ware, Doreen, Zhang, Jianwei, McNally, Kenneth, Wing, Rod

A large sequenced mutant library - valuable reverse genetic resource that covers 98% of sorghum genes

15 Dec 2023 | The Plant Journal
Jiao, Yinping, Nigam, Deepti, Barry, Kerrie, Daum, Chris, Yoshinaga, Yuko, Lipzen, Anna, Khan, Adil, Parasa, Sai-Praneeth, Wei, Sharon, Lu, Zhenyuan, Tello-Ruiz, Marcela, Dhiman, Pallavi, Burow, Gloria, Hayes, Chad, Chen, Junping, Brandizzi, Federica, Mortimer, Jenny, Ware, Doreen, Xin, Zhanguo

Expression Atlas update: insights from sequencing data at both bulk and single cell level

22 Nov 2023 | Nucleic Acids Research (NAR) | :gkad1021
George, Nancy, Fexova, Silvie, Fuentes, Alfonso, Madrigal, Pedro, Bi, Yalan, Iqbal, Haider, Kumbham, Upendra, Nolte, Nadja, Zhao, Lingyun, Thanki, Anil, Yu, Iris, Marugan Calles, Jose, Erdos, Karoly, Vilmovsky, Liora, Kurri, Sandeep, Vathrakokoili-Pournara, Anna, Osumi-Sutherland, David, Prakash, Ananth, Wang, Shengbo, Tello-Ruiz, Marcela, Kumari, Sunita, Ware, Doreen, Goutte-Gattat, Damien, Hu, Yanhui, Brown, Nick, Perrimon, Norbert, Vizcaíno, Juan, Burdett, Tony, Teichmann, Sarah, Brazma, Alvis, Papatheodorou, Irene

Ensembl 2024

11 Nov 2023 | Nucleic Acids Research (NAR) | :gkad1049
Harrison, Peter, Amode, M, Austine-Orimoloye, Olanrewaju, Azov, Andrey, Barba, Matthieu, Barnes, If, Becker, Arne, Bennett, Ruth, Berry, Andrew, Bhai, Jyothish, Bhurji, Simarpreet, Boddu, Sanjay, Branco Lins, Paulo, Brooks, Lucy, Ramaraju, Shashank, Campbell, Lahcen, Martinez, Manuel, Charkhchi, Mehrnaz, Chougule, Kapeel, Cockburn, Alexander, Davidson, Claire, De Silva, Nishadi, Dodiya, Kamalkumar, Donaldson, Sarah, El Houdaigui, Bilal, Naboulsi, Tamara, Fatima, Reham, Giron, Carlos, Genez, Thiago, Grigoriadis, Dionysios, Ghattaoraya, Gurpreet, Martinez, Jose, Gurbich, Tatiana, Hardy, Matthew, Hollis, Zoe, Hourlier, Thibaut, Hunt, Toby, Kay, Mike, Kaykala, Vinay, Le, Tuan, Lemos, Diana, Lodha, Disha, Marques-Coelho, Diego, Maslen, Gareth, Merino, Gabriela, Mirabueno, Louisse, Mushtaq, Aleena, Hossain, Syed, Ogeh, Denye, Sakthivel, Manoj, Parker, Anne, Perry, Malcolm, Piližota, Ivana, Poppleton, Daniel, Prosovetskaia, Irina, Raj, Shriya, Pérez-Silva, José, Salam, Ahamed, Saraf, Shradha, Saraiva-Agostinho, Nuno, Sheppard, Dan, Sinha, Swati, Sipos, Botond, Sitnik, Vasily, Stark, William, Steed, Emily, Suner, Marie-Marthe, Surapaneni, Likhitha, Sutinen, Kyösti, Tricomi, Francesca, Urbina-Gómez, David, Veidenberg, Andres, Walsh, Thomas, Ware, Doreen, Wass, Elizabeth, Willhoft, Natalie, Allen, Jamie, Alvarez-Jarreta, Jorge, Chakiachvili, Marc, Flint, Bethany, Giorgetti, Stefano, Haggerty, Leanne, Ilsley, Garth, Keatley, Jon, Loveland, Jane, Moore, Benjamin, Mudge, Jonathan, Naamati, Guy, Tate, John, Trevanion, Stephen, Winterbottom, Andrea, Frankish, Adam, Hunt, Sarah, Cunningham, Fiona, Dyer, Sarah, Finn, Robert, Martin, Fergal, Yates, Andrew

Registration of 252 sequenced sorghum mutants as a community reverse genetic resource

1 Sep 2023 | Journal of Plant Registrations | 17(3):599-604
Xin, Z, Jiao, Y, Burow, G, Hayes, C, Chen, J, Burke, J, Pugh, N, Ware, D

Engineering homoeologs provide a fine scale for quantitative traits in polyploid

2 Aug 2023 | Plant Biotechnology Journal | :1-15
Lee, Eun, Heo, Jung, Bang, Woo, Chougule, Kapeel, Waminal, Nomar, Hong, Nguyen, Kim, Min, Beak, Hong, Kim, Yong, Priatama, Ryza, Jang, Ji, Cha, Kang, Son, Seung, Rajendran, Sujeevan, Choo, Young-Kug, Bae, Jong, Kim, Chul, Lee, Young, Bae, Sangsu, Jones, Jonathan, Sohn, Kee, Lee, Jiyoung, Kim, Hyun, Hong, Jong, Ware, Doreen, Kim, Keunhwa, Park, Soon

HPC-based genome variant calling workflow (HPC-GVCW)

2023 | bioRxiv
Zhou, Yong, Kathiresan, Nagarajan, Yu, Zhichao, Rivera, Luis, Thimma, Manjula, Manickam, Keerthana, Chebotarov, Dmytro, Mauleon, Ramil, Chougule, Kapeel, Wei, Sharon, Gao, Tingting, Green, Carl, Zuccolo, Andrea, Ware, Doreen, Zhang, Jianwei, McNally, Kenneth, Wing, Rod

An improved reference of the grapevine genome reasserts the origin of the PN40024 highly homozygous genotype

2 May 2023 | G3: Genes, Genomes, Genetics | 13(5):jkad067
Velt, Amandine, Frommer, Bianca, Blanc, Sophie, Holtgräwe, Daniela, Duchêne, Éric, Dumas, Vincent, Grimplet, Jérôme, Hugueney, Philippe, Kim, Catherine, Lahaye, Marie, Matus, José, Navarro-Payá, David, Orduña, Luis, Tello-Ruiz, Marcela, Vitulo, Nicola, Ware, Doreen, Rustenholz, Camille, Whiteman, N

The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding

May 2023 | Horticulture Research | 10(5):uhad061
Shi, Xiaoya, Cao, Shuo, Wang, Xu, Huang, Siyang, Wang, Yue, Liu, Zhongjie, Liu, Wenwen, Leng, Xiangpeng, Peng, Yanling, Wang, Nan, Wang, Yiwen, Ma, Zhiyao, Xu, Xiaodong, Zhang, Fan, Xue, Hui, Zhong, Haixia, Wang, Yi, Zhang, Kekun, Velt, Amandine, Avia, Komlan, Holtgräwe, Daniela, Grimplet, Jérôme, Matus, José, Ware, Doreen, Wu, Xinyu, Wang, Haibo, Liu, Chonghuai, Fang, Yuling, Rustenholz, Camille, Cheng, Zongming, Xiao, Hua, Zhou, Yongfeng

Pan-genome inversion index reveals evolutionary insights into the subpopulation structure of Asian rice

21 Mar 2023 | Nature Communications | 14(1):1567
Zhou, Yong, Yu, Zhichao, Chebotarov, Dmytro, Chougule, Kapeel, Lu, Zhenyuan, Rivera, Luis, Kathiresan, Nagarajan, Al-Bader, Noor, Mohammed, Nahed, Alsantely, Aseel, Mussurova, Saule, Santos, João, Thimma, Manjula, Troukhan, Maxim, Fornasiero, Alice, Green, Carl, Copetti, Dario, Kudrna, David, Llaca, Victor, Lorieux, Mathias, Zuccolo, Andrea, Ware, Doreen, McNally, Kenneth, Zhang, Jianwei, Wing, Rod

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