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Ivan Iossifov

Ivan Iossifov

Professor

Ph.D., Columbia University, 2008

iossifov@cshl.edu | 516-367-6947

Faculty Profile

Every gene has a job to do, but genes rarely act alone. Biologists have built models of molecular interaction networks that represent the complex relationships between thousands of different genes. I am using computational approaches to help define these relationships, work that is helping us to understand the causes of common diseases including autism, bipolar disorder, and cancer.

Ivan Iossifov focuses on the development of new methods and tools for genomic sequence analysis and for building and using molecular networks, and he applies them to specific biomedical problems. He studies the genetics of common diseases in humans using two main tools: next-generation sequencing and molecular networks representing functional relationships among genetic loci. These approaches in combination enable the kind of large-scale studies necessary for furthering our understanding of the complex etiology of disorders such as autism, bipolar disorder, and cancer.

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All Publications

The Genotype and Phenotypes in Families (GPF) platform manages the large and complex data at SFARI

11 Feb 2024 | bioRxiv
Chorbadjiev, Liubomir, Cokol, Murat, Weinstein, Zohar, Shi, Kevin, Fleisch, Chris, Dimitrov, Nikolay, Mladenov, Svetlin, Xu, Simon, Hall, Jake, Ford, Steven, Lee, Yoon-Ha, Yamrom, Boris, Marks, Steven, Munoz, Adriana, Lash, Alex, Volfovsky, Natalia, Iossifov, Ivan

Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction

5 Oct 2023 | American Journal of Human Genetics | 110(10):1750-1768
Shi, Xi, Lu, Congyi, Corman, Alba, Nikish, Alexandra, Zhou, Yang, Platt, Randy, Iossifov, Ivan, Zhang, Feng, Pan, Jen, Sanjana, Neville

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants

9 Aug 2023 | Genetics | 224(4):iyad115
Einson, Jonah, Glinos, Dafni, Boerwinkle, Eric, Castaldi, Peter, Darbar, Dawood, de Andrade, Mariza, Ellinor, Patrick, Fornage, Myriam, Gabriel, Stacey, Germer, Soren, Gibbs, Richard, Hersh, Craig, Johnsen, Jill, Kaplan, Robert, Konkle, Barbara, Kooperberg, Charles, Nassir, Rami, Loos, Ruth, Meyers, Deborah, Mitchell, Braxton, Psaty, Bruce, Vasan, Ramachandran, Rich, Stephen, Rienstra, Michael, Rotter, Jerome, Saferali, Aabida, Shoemaker, Moore, Silverman, Edwin, Smith, Albert, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mohammadi, Pejman, Castel, Stephane, Iossifov, Ivan, Lappalainen, Tuuli, Zhao, H

Sharing parental genomes by siblings concordant or discordant for autism

14 Jun 2023 | Cell Genomics | 3(6):100319
Wroten, Mathew, Yoon, Seungtai, Andrews, Peter, Yamrom, Boris, Ronemus, Michael, Buja, Andreas, Krieger, Abba, Levy, Dan, Ye, Kenny, Wigler, Michael, Iossifov, Ivan

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants

31 Jan 2023 | bioRxiv
Einson, Jonah, Glinos, Dafni, Boerwinkle, Eric, Castaldi, Peter, Darbar, Dawood, de Andrade, Mariza, Ellinor, Patrick, Fornage, Myriam, Gabriel, Stacey, Germer, Soren, Gibbs, Richard, Hersh, Craig, Johnsen, Jill, Kaplan, Robert, Konkle, Barbara, Kooperberg, Charles, Nassir, Rami, Loos, Ruth, Meyers, Deborah, Mitchell, Braxton, Psaty, Bruce, Vasan, Ramachandran, Rich, Stephen, Rienstra, Michael, Rotter, Jerome, Saferali, Aabida, Shoemaker, M, Silverman, Edwin, Smith, Albert, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mohammadi, Pejman, Castel, Stephane, Iossifov, Ivan, Lappalainen, Tuuli

Snakeobjects: an object-oriented workflow management system

12 Dec 2022 | bioRxiv
Yamrom, Boris, Lee, Yoon-ha, Marks, Steven, Chorbadjiev, Lubomir, Meyer, Hannah, Iossifov, Ivan

Rates of contributory de novo mutation in high and low-risk autism families.

1 Sep 2021 | Communications Biology | 4(1):1026
Yoon, Seungtai, Munoz, Adriana, Yamrom, Boris, Lee, Yoon-Ha, Andrews, Peter, Marks, Steven, Wang, Zihua, Reeves, Catherine, Winterkorn, Lara, Krieger, Abba, Buja, Andreas, Pradhan, Kith, Ronemus, Michael, Baldwin, Kristin, Levy, Dan, Wigler, Michael, Iossifov, Ivan

Mapping and characterization of structural variation in 17,795 human genomes.

Jul 2020 | Nature | 583(7814):83-89
Abel, Haley, Larson, David, Regier, Allison, Chiang, Colby, Das, Indraniel, Kanchi, Krishna, Layer, Ryan, Neale, Benjamin, Salerno, William, Reeves, Catherine, Buyske, Steven, NHGRI Centers for Common Disease Genomics, Matise, Tara, Muzny, Donna, Zody, Michael, Lander, Eric, Dutcher, Susan, Stitziel, Nathan, Hall, Ira

N-terminal Variant Asp14Asn of the Human p70 S6 Kinase 1 Enhances Translational Signaling Causing Different Effects in Developing and Mature Neuronal Cells

5 Mar 2020 | Neurobiology of Learning and Memory | 171(107203)
Venkatasubramani, J, Subramanyam, P, Pal, R, Reddy, B, Srinivasan, D, Chattarji, S, Iossifov, I, Klann, E, Bhattacharya, S

De novo variants in FBXO11 cause a syndromic form of intellectual disability with behavioral problems and dysmorphisms

24 Jan 2019 | European Journal of Human Genetics | 27(5):738-746
Jansen, S, van der Werf, I, Innes, A, Afenjar, A, Agrawal, P, Anderson, I, Atwal, P, van Binsbergen, E, van den Boogaard, M, Castiglia, L, Coban-Akdemir, Z, van Dijck, A, Doummar, D, van Eerde, A, van Essen, A, van Gassen, K, Guillen Sacoto, M, van Haelst, M, Iossifov, I, Jackson, J, Judd, E, Kaiwar, C, Keren, B, Klee, E, Klein Wassink-Ruiter, J, Meuwissen, M, Monaghan, K, de Munnik, S, Nava, C, Ockeloen, C, Pettinato, R, Racher, H, Rinne, T, Romano, C, Sanders, V, Schnur, R, Smeets, E, Stegmann, A, Stray-Pedersen, A, Sweetser, D, Terhal, P, Tveten, K, VanNoy, G, de Vries, P, Waxler, J, Willing, M, Pfundt, R, Veltman, J, Kooy, R, Vissers, Lelm, de Vries, B

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