Research Assistant Professor
Max-Delbrueck Center for Molecular Medicine, Freie Universitaet, Berlin/Germany, 2009
firstname.lastname@example.org | 516-367-8836
Transposable elements make up half of our DNA. They control gene expression and have been a major evolutionary force in all organisms. The Schorn lab investigates how small RNAs identify and silence transposable elements when they become active during development and disease.
‘Mobile genes’ or transposable elements, which are closely related to viruses, promote active gene expression in a selfish manner. These elements are usually buried in inactive, condensed DNA by their host to prevent mutagenic damage. However, both stem cells in the embryo and cancer cells undergo genome-wide reprogramming that re-activates silent transposable elements. My lab is exploring how the host recognizes transposons amongst thousands of genes and non-coding DNA and specifically restricts transposon mobility.
We found that a highly conserved 18 nucleotide sequence motif is the Achille’s heel of a wide-spread class of transposable elements that are closely related to retroviruses such as HIV. These retroelements initiate replication at the 18 nucleotide binding site using transfer RNA (tRNA), an essential RNA component of the cell. In turn, cells produce short fragments of tRNAs that we discovered inhibit this class of retroelements. These tRNA fragments are processed from mature tRNAs under yet unknown conditions and potentially protect many cell types in eukaryotes. We are investigating under which conditions cells produce this class of small RNAs and assessing their impact on development and pluripotency. tRNA fragments are an ancient link between the ‘RNA interference’ silencing machinery, transposons and genome stability, with potential roles in trans-generational inheritance and cancer.
Andrea Schorn zooms in on small RNAs in the cell
April 29, 2019
As much as 98 percent of the human genome consists of “dark matter”: sequences that don’t code for proteins or present immediately visible functions. But to Dr. Andrea Schorn, this dark matter is actually quite bright. Schorn, with a Ph.D. on mobile DNA from the Max-Delbrück Center for Molecular Medicine, joins the CSHL faculty as...
Schorn, A. J. and Martienssen, R. (2019) Getting in LINE with Replication. Molecular Cell, 74(3) pp. 415-417.
Schorn, Andrea J. and Martienssen, Rob (2018) Tie-Break: Host and Retrotransposons Play tRNA. Trends in Cell Biology, 28(10) pp. 793-806.
Schorn, A. J. and Gutbrod, M. J. and LeBlanc, C. and Martienssen, R. (2017) LTR-Retrotransposon Control by tRNA-Derived Small RNAs. Cell, 170(1) pp. 61-71.e11.
Ingouff, M. and Selles, B. and Michaud, C. and Vu, T. M. and Berger, F. and Schorn, A. J. and Autran, D. and Van Durme, M. and Nowack, M. K. and Martienssen, R. A. and Grimanelli, D. (2017) Live-cell analysis of DNA methylation during sexual reproduction in Arabidopsis reveals context and sex-specific dynamics controlled by noncanonical RdDM. Genes Dev, 31(1) pp. 72-83.
Walisko, O. and Schorn, A. and Rolfs, F. and Devaraj, A. and Miskey, C. and Izsvak, Z. and Ivics, Z. (2008) Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators. Molecular Therapy, 16(2) pp. 359-69.Additional materials of the author at
CSHL Institutional Repository