The human genome isn’t entirely human. The descendants of ancient viruses and other transposons make up about half of our DNA. Some of these transposable elements (TEs) are millions of years old. Some are much younger. No matter their age, they’ve become essential for human development.
But outside viruses still exist. How does our genome know which are enemy invaders, and which are important allies?
In this video, step inside the lab of Cold Spring Harbor Laboratory Assistant Professor Andrea Schorn, where she’s uncovering the molecular defenses that filter good TEs from bad. Understanding how our genome recognizes friend from foe could be key for improving pregnancy outcomes and treating diseases like cancer and HIV
Read the related story: Where did our DNA come from?