Sepideh Gholami

Sepideh Gholami

Adjunct Associate Professor

M.A.S., University of California, Davis
M.D., Stanford University School of Medicine

gholami1@cshl.edu |

Institutional Profile   Faculty Profile

Dr. Sepideh Gholami M.D., M.A.S. is a board-certified surgeon scientist with dual fellowship training in Complex General Surgical Oncology and Hepatopancreatobiliary Surgery. Dr. Gholami serves as the Director of the Liver Multidisciplinary Clinic, Hepatic Artery Infusion Pump Program, and Translational Research in Surgical Oncology at Northwell Health. She has focused her efforts on building a multidisciplinary liver surgery program with liver-directed therapies/regional therapies, including a hepatic artery infusion pump program for patients with hepatobiliary and metastatic malignancies. Dr. Gholami’s mission is to diversify and improve the research and clinical trial portfolio at Northwell Health Cancer Institute. She also has a joint appointment as an Adjunct Associate Professor at Cold Spring Harbor Laboratory.

Our laboratory has a vested interest in developing novel diagnostic and prognostic biomarkers through designing high-impact clinical trials to improve patient outcomes in with primary and secondary liver cancers. Our studies interrogate the tumor microenvironment, spatiotemporal dynamics of tumor-immune crosstalk, and response pathways that play a critical role in anti-cancer therapeutics. Using a combination of mouse models, human organoids, and tissue culture slices from patient avatars, we work in a multi-disciplinary, collaborative effort to assess and translate findings from our model systems to evaluate novel therapeutics in translational oncology.

2023 Cancer Immunotherapy Winter School Program, Society for Immunotherapy of Cancer (SITC)
2022 Research Fellowship Award, Society of Translational Oncology Fellows’ Forum
2021 Society of Surgical Oncology Young Investigator Award
2020 Southwest Oncology Group Young Investigator Award
2020 Cancer Research Committee Award, University of California
2020 Career Development Award for Clinical Oncology, Paul Calabresi K12 Scholar
2020 Joel J. Roslyn Faculty Research Award, Association of Academic Surgeons
2019 Research Fellowship Award, Association of Women Surgeons
2019 Cancer Pilot Grant for Young Investigators, UC Davis Medical Center
2019 Selected Participant, ASCO/AACR Workshop on Methods in Clinical Cancer Research
2014 Hilary Sanfey Outstanding Resident Award, Association of Women Surgeons
2014 General Surgery Resident Research Award, Stanford University Medical Center
2013 General Surgery Resident Research Award, Stanford University Medical Center

1. Beechinor RJ, Abidalhassan MF, Small DF, Hoang HK, Lamba R, Loehfelm TW, Foster CC, Koontz MZ, Kim EJ, Cho M, Gholami S. A Case of Heavily Pretreated HER2+ Colorectal Liver Metastases Responsive to Hepatic Arterial Infusion Chemotherapy. Clin Colorectal Cancer. 2023 Jun;22(2):245-249. doi: 10.1016/j.clcc.2023.02.006. Epub 2023 Feb 24. PMID: 36931913.

2. Cho M, Beechinor R, Gholami S, Grothey A. Precision Medicine for the Treatment of Colorectal Cancer: the Evolution and Status of Molecular Profiling and Biomarkers. Current Colorectal Cancer Reports. 2021/08/01 2021;17(4):55-68. doi:10.1007/s11888-021-00466-7

3. D’Angelica MI, Ellis RJ, Liu JB, Brajcich BC, Gönen M, Thompson VM, Cohen ME, Seo SK, Zabor EC, Babicky ML, Bentrem DJ, Behrman SW, Bertens KA, Celinski SA, Chan CHF, Dillhoff M, Dixon MEB, Fernandez-Del Castillo C, Gholami S, House MG, Karanicolas PJ, Lavu H, Maithel SK, McAuliffe JC, Ott MJ, Reames BN, Sanford DE, Sarpel U, Scaife CL, Serrano PE, Smith T, Snyder RA, Talamonti MS, Weber SM, Yopp AC, Pitt HA, Ko CY. Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial. JAMA. 2023 May 9;329(18):1579-1588. doi: 10.1001/jama.2023.5728. PMID: 37078771; PMCID: PMC10119777.

4. Del Piccolo N, Shirure VS, Bi Y, Peter Goedegebuure S, Gholami S, Hughes CCW, Fields RC, George SC. Tumor-on-chip modeling of organ-specific cancer and metastasis. Adv Drug Deliv Rev. 2021 May 17:S0169-409X(21)00164-2. doi: 10.1016/j.addr.2021.05.008. Epub ahead of print. PMID: 34015419

5. Gholami S, Colby S, Horowitz DP, Guthrie KA, Ben-Josef E, El-Khoueiry AB, Blanke CD, Philip PA, Kachnic LA, Ahmad SA, Rocha FG. Adjuvant Chemoradiation in Patients with Lymph Node-Positive Biliary Tract Cancers: Secondary Analysis of a Single-Arm Clinical Trial (SWOG 0809). Ann Surg Oncol. 2023 Mar;30(3):1354-1363. doi: 10.1245/s10434-022-12863-9. Epub 2023 Jan 9. PMID: 36622529.

6. Gholami S, Grothey A, Lenz HJ. Microsatellite Stable Colorectal Liver Metastases-Understanding the Mechanisms of Immune Resistance. JAMA Netw Open. 2021 Aug 2;4(8):e2119025. doi: 10.1001/jamanetworkopen.2021.19025. PMID: 34369996

7. Gholami S, Kemeny NE, Boucher TM, Gönen M, Cercek A, Kingham TP, Balachandran V, Allen P, DeMatteo R, Drebin J, Jarnagin W, D’Angelica M. Adjuvant Hepatic Artery Infusion Chemotherapy is Associated With Improved Survival Regardless of KRAS Mutation Status in Patients With Resected Colorectal Liver Metastases: A Retrospective Analysis of 674 Patients. Ann Surg. 2020 Aug;272(2):352-356. doi: 10.1097/SLA.0000000000003248. PMID: 32675549.

8. Gholami S, Stewart S, Kemeny N, Gönen M, Groot Koerkamp B, Cercek A, Kingham P, Balachandran V, Allen P, DeMatteo R, Wei A, Connell L, Drebin J, Jarnagin W, D’Angelica M. Impact of Primary Tumor Laterality on Adjuvant Hepatic Artery Infusion Pump Chemotherapy in Resected Colon Cancer Liver Metastases: Analysis of 487 Patients. Ann Surg Oncol. 2020 Nov 23. doi: 10.1245/s10434-020-09369-7. Epub ahead of print. PMID: 33230748.

9. Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C. Treatment of Metastatic Colorectal Cancer: ASCO Guideline. J Clin Oncol. 2023 Jan 20;41(3):678-700. doi: 10.1200/JCO.22.01690. Epub 2022 Oct 17. PMID: 36252154.

10. Yoon PS, Del Piccolo N, Shirure VS, Peng Y, Kirane A, Canter RJ, Fields RC, George SC, Gholami S. Advances in Modeling the Immune Microenvironment of Colorectal Cancer. Front. Immunol. 2021.11:614300. doi: 10.3389/fimmu.2020.614300