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Mikala Egeblad

Mikala Egeblad

Associate Professor

Ph.D., University of Copenhagen and the Danish Cancer Society, 2000

egeblad@cshl.edu | (516) 367-6852

Egeblad Lab Website

Cancer cells are surrounded by immune cells, blood vessels, chemical signals and a support matrix—collectively, the tumor microenvironment. Most microenvironments help tumors grow and metastasize, but some can restrict tumors. My lab studies how to target the bad microenvironments and support the good ones to combat cancer.

Mikala Egeblad and colleagues study cancer and, in particular, the microenvironment in which the cancer cells arise and live. Solid tumors are abnormally organized tissues that contain not only cancer cells, but also various other stromal cell types and an extracellular matrix, and these latter components constitute the microenvironment. Communications between the different components of the tumor influence its growth, its response to therapy, and its ability to metastasize. Among the tumor-associated stromal cells, the lab’s main focus is on myeloid-derived immune cells, a diverse group of cells that can enhance angiogenesis and metastasis and suppress the cytotoxic immune response against tumors. Egeblad is interested in how different types of myeloid cells are recruited to tumors and how their behaviors—for example, their physical interactions with cancer cells and other immune cells—influence cancer progression, including metastasis. The Egeblad lab studies the importance of the myeloid cells using mouse models of breast and pancreatic cancer and real-time imaging of cells in tumors in live mice. This enables them to follow the behaviors of and the interactions between cancer and myeloid cells in tumors during progression or treatment. This technique was instrumental when the lab showed that cancer drug therapy can be boosted by altering components of the tumor microenvironments, specifically reducing either matrix metalloproteinases (enzymes secreted by myeloid cells) or chemokine receptors (signal receptors on myeloid cells). Most recently, the Egeblad lab has showed that when a specific type of myeloid cell, called neutrophil, is activated during inflammation it can awaken sleeping cancer to cause cancer recurrence. The neutrophils do so by forming so-called neutrophil extracellular traps, structures of extracellular DNA and these alter the extracellular matrix surrounding the sleeping cancer cells to provide a wake-up signal. 

Albrengues, J. and Shields, M. A. and Ng, D. and Park, C. G. and Ambrico, A. and Poindexter, M. E. and Upadhyay, P. and Uyeminami, D. L. and Pommier, A. and Kuttner, V. and Bruzas, E. and Maiorino, L. and Bautista, C. and Carmona, E. M. and Gimotty, P. A. and Fearon, D. T. and Chang, K. and Lyons, S. K. and Pinkerton, K. E. and Trotman, L. C. and Goldberg, M. S. and Yeh, J. T. and Egeblad, M. (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science, 361(6409)

Park, J. and Wysocki, R. W. and Amoozgar, Z. and Maiorino, L. and Fein, M. R. and Jorns, J. and Schott, A. F. and Kinugasa-Katayama, Y. and Lee, Y. and Won, N. H. and Nakasone, E. S. and Hearn, S. A. and Kuttner, V. and Qiu, J. and Almeida, A. S. and Perurena, N. and Kessenbrock, K. and Goldberg, M. S. and Egeblad, M. (2016) Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med, 8(361) pp. 361ra138.

Park, Jae-Hyun and Rasch, Morten Grønbech and Qiu, Jing and Lund, Ida Katrine and Egeblad, Mikala (2015) Presence of Insulin-Like Growth Factor Binding Proteins Correlates With Tumor-Promoting Effects of Matrix Metalloproteinase 9 in Breast Cancer. Neoplasia, 17(5) pp. 421-433.

Nakasone, E. S. and Askautrud, H. A. and Kees, T. and Park, J. H. and Plaks, V. and Ewald, A. J. and Fein, M. and Rasch, M. G. and Tan, Y. X. and Qiu, J. and Park, J. and Sinha, P. and Bissell, M. J. and Frengen, E. and Werb, Z. and Egeblad, M. (2012) Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance. Cancer Cell, 21(4) pp. 488-503.

Egeblad, M. and Nakasone, E. S. and Werb, Z. (2010) Tumors as Organs: Complex Tissues that Interface with the Entire Organism. Developmental Cell, 18(6) pp. 884-901.

Additional materials of the author at
CSHL Institutional Repository