Devastating diseases like cancer and autism can be caused by spontaneous changes to our DNA—mutations first appearing in the child, or in our tissues as we age. We are developing methods to discover these changes in individuals, tumors, and even single cells, to promote early detection and treatments
Michael Wigler’s work provides a new paradigm for understanding and exploring human disease. The Wigler lab studies human cancer and the contribution of new mutation to genetic disorders. The cancer effort (with James Hicks, Alex Krasnitz, and Lloyd Trotman) focuses on breast and prostate cancers. It involves collaborative clinical studies to discover mutational patterns predicting treatment response and outcome and the development of diagnostics to detect cancer cells in bodily fluids such as blood and urine. The major tools are single-cell DNA and RNA analysis. The single-cell methods, which are in development, are also being applied to problems in neurobiology (with Josh Huang and Pavel Osten) to characterize neuronal subtypes, somatic mutation, and monoallelic expression. The Wigler lab’s genetic efforts are a collaboration with Ivan Iossifov and Dan Levy, and this team focuses on determining the role of new mutations in pediatric disorders. In a large-scale population sequencing project with W. Richard McCombie and the Genome Sequencing Center at Washington University in St. Louis, and supported by the Simons Foundation, the team has proven the contribution of this mechanism to autism. The work further suggests a relationship between the mutational targets in autism and the process of neuroplasticity that lies at the heart of learning. Smaller-scale population studies of congenital heart disease and pediatric cancer (collaborations with scientists at Columbia University and Memorial Sloan- Kettering Cancer Center, respectively) also point to new mutation as a causal factor in these disorders.
The genetic landscape of autism
August 16, 2022
CSHL Professor Michael Wigler discusses 20 years of research to paint a complete picture of the genetic causes of autism.
After 100 years of research, autism remains a puzzle
August 4, 2022
One geneticist is determined to piece together the causes of autism.
Tuveson and Wigler elected AACR Academy Fellows
May 12, 2020
CSHL Cancer Center Director David Tuveson and Professor Michael Wigler were chosen as 2020 Fellows of the AACR Academy.
Dog adaptations are like brain adaptations
May 6, 2020
To understand autism, CSHL Professor Michael Wigler thinks about how biological systems adapt over generations.
The status of autism research—in verse
April 29, 2020
CSHL Professor Michael Wigler drafted a poem explaining what we know and what we need to learn about autism.
CSHL investigators rank among world’s most highly cited
December 11, 2019
Seven researchers affiliated with CSHL are among the scientists producing the top 1 percent of the most highly-cited research in the world.
Portrait of a Neuroscience Powerhouse
April 27, 2018
A relatively small neuroscience group at CSHL is having an outsized impact on a dynamic and highly competitive field
Autism genetics study calls attention to impaired motor skills, general cognitive impairment
February 7, 2018
New research on the genetic causes of autism calls attention to diminished motor skills and suggests the importance of broad cognitive impairment
New method to determine before surgery which prostate tumors pose a lethal threat
December 1, 2017
The news about prostate cancer can be confusing. It’s the third most common cancer type among Americans.
Next-gen cancer test
November 24, 2017
Knowing that cancers become lethal when they spread, investigators at Cold Spring Harbor Laboratory seek a way of detecting tumors much earlier
20 May 2020 | JCO Clinical Cancer Informatics | 4:464-471
Chorbadjiev, L, Kendall, J, Alexander, J, Zhygulin, V, Song, J, Wigler, M, Krasnitz, A
Novel Insights Into Breast Cancer Copy Number Genetic Heterogeneity Revealed by Single-Cell Genome Sequencing
13 May 2020 | eLife | 9:e51480
Baslan, T, Kendall, J, Volyanskyy, K, McNamara, K, Cox, H, D'Italia, S, Ambrosio, F, Riggs, M, Rodgers, L, Leotta, A, Song, J, Mao, Y, Wu, J, Shah, R, Gularte-Merida, R, Chadalavada, K, Nanjangud, G, Varadan, V, Gordon, A, Curtis, C, Krasnitz, A, Dimitrova, N, Harris, L, Wigler, M, Hicks, J
24 Feb 2020 | Developmental Cell | 52(4):413-428
Vasudevan, A, Baruah, P, Smith, J, Wang, Z, Sayles, N, Andrews, P, Kendall, J, Leu, J, Chunduri, N, Levy, D, Wigler, M, Storchova, Z, Sheltzer, J
Multiplex Accurate Sensitive Quantitation (MASQ) With Application to Minimal Residual Disease in Acute Myeloid Leukemia
21 Feb 2020 | Nucleic Acids Research | 48(7):e40
Moffitt, A, Spector, M, Andrews, P, Kendall, J, Alexander, J, Stepansky, A, Ma, B, Kolitz, J, Chiorazzi, N, Allen, S, Krasnitz, A, Wigler, M, Levy, D, Wang, Z
14 Nov 2019 | Genome Research | 30(1):49-61
Li, S, Kendall, J, Park, S, Wang, Z, Alexander, J, Moffitt, A, Ranade, N, Danyko, C, Gegenhuber, B, Fischer, S, Robinson, B, Lepor, H, Tollkuhn, J, Gillis, J, Brouzes, E, Krasnitz, A, Levy, D, Wigler, M
12 Sep 2022 | Nucleic Acids Research | :gkac723
Wang, Zihua, Moffitt, Andrea, Andrews, Peter, Wigler, Michael, Levy, Dan
13 Jul 2022 | Nucleic Acids Research
Li, Siran, Park, Sarah, Ye, Catherine, Danyko, Cassidy, Wroten, Matthew, Andrews, Peter, Wigler, Michael, Levy, Dan
1 Sep 2021 | Communications Biology | 4(1):1026
Yoon, Seungtai, Munoz, Adriana, Yamrom, Boris, Lee, Yoon-Ha, Andrews, Peter, Marks, Steven, Wang, Zihua, Reeves, Catherine, Winterkorn, Lara, Krieger, Abba, Buja, Andreas, Pradhan, Kith, Ronemus, Michael, Baldwin, Kristin, Levy, Dan, Wigler, Michael, Iossifov, Ivan
Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.
1 Oct 2020 | Cancer Discovery | 10(10):1566-1589
Miyabayashi, Koji, Baker, Lindsey, Deschênes, Astrid, Traub, Benno, Caligiuri, Giuseppina, Plenker, Dennis, Alagesan, Brinda, Belleau, Pascal, Li, Siran, Kendall, Jude, Jang, Gun, Kawaguchi, Risa, Somerville, Tim, Tiriac, Hervé, Hwang, Chang-Il, Burkhart, Richard, Roberts, Nicholas, Wood, Laura, Hruban, Ralph, Gillis, Jesse, Krasnitz, Alexander, Vakoc, Christopher, Wigler, Michael, Notta, Faiyaz, Gallinger, Steven, Park, Youngkyu, Tuveson, David
Jul 2020 | Nature | 583(7814):83-89
Abel, Haley, Larson, David, Regier, Allison, Chiang, Colby, Das, Indraniel, Kanchi, Krishna, Layer, Ryan, Neale, Benjamin, Salerno, William, Reeves, Catherine, Buyske, Steven, NHGRI Centers for Common Disease Genomics, Matise, Tara, Muzny, Donna, Zody, Michael, Lander, Eric, Dutcher, Susan, Stitziel, Nathan, Hall, Ira