Hannah Meyer
Assistant Professor
Cancer Center Member
Ph.D., University of Cambridge, EMBL-EBI, 2018
hmeyer@cshl.edu | 516-367-8468
A properly functioning immune system must be able to recognize diseased cells and foreign invaders among the multitude of healthy cells in the body. This ability is essential to both prevent autoimmune diseases and fight infections and cancer. We study how a specific type of immune cells, known as T cells, are educated to make this distinction during development.
The thymus generates and selects a highly variable yet specific T cell repertoire which discriminates between healthy and non-healthy self and dangerous non-self antigens. My research group uses a systems immunology approach to dissect the mechanisms crucial to the selection processes in the thymus. We develop experimental techniques and combine the resulting data with innovative computational models to generate accurate and testable hypotheses about tissue-level organ physiology.
Studying thymus physiology from a qualitative and quantitative perspective will provide us with a more fine-grained understanding of the selection processes and their down-stream consequences such as auto-immunity, cancer immunosurveillance and immune deficiency.
The 2023 CSHL Volleyball League Finals
October 11, 2023
With a wide swath of the CSHL community in attendance, we got an up-close view of the action. How close? Think “camera on the ref’s head” close.
Eight serving one: CSHL volleyball mid-season report
August 2, 2023
CSHL’s 32nd Volleyball League season sees eight teams battling for the coveted Tiernan Cup and a year’s worth of bragging rights.
How popular steroids could mess up some cancer treatments
June 23, 2023
Scientists have long wondered how common steroids work and why cancer immunotherapy fails in certain patients. The answers may be one and the same.
President’s essay: Bringing bold visions to life
May 26, 2023
CSHL President & CEO Bruce Stillman sees the Laboratory as a global hub for scientific expertise and a powerful launchpad for early-career scientists.
How the thymus trains T cells to fight infections
August 2, 2022
CSHL scientists identified, for the first time, the RNA in humans used to train T cells to attack dangerous or foreign proteins in the body.
CSHL Fellow Hannah Meyer wins UK Biobank researcher award
November 17, 2021
The UK Biobank recognized CSHL Fellow Hannah Meyer’s scientific achievements in understanding the inner workings of the human heart.
Team P.E. Revival wins CSHL volleyball championship
September 29, 2021
Team PE Revival won the thirtieth annual CSHL beach volleyball tournament by winning two out of three matches.
Local Regeneron scholars celebrated by Congressman Suozzi
March 5, 2021
Over twenty local high school students were named scholars in the Regeneron Science Talent Search national competition and awarded $2,000 scholarships.
How does anyone stay healthy in a world full of germs?
January 15, 2021
Computational biology is uncovering the immune system’s tricks for identifying foreign invaders.
New genetic research to understand racial disparity in cancers
September 8, 2020
Cold Spring Harbor Laboratory will study the genetic contributions of ethnicity to colon, endometrial, and pancreas cancers in African Americans.
All Publications
BATMAN: Improved T cell receptor cross-reactivity prediction benchmarked on a comprehensive mutational scan database
25 Jan 2024 | bioRxiv
Banerjee, Amitava, Pattinson, David, Wincek, Cornelia, Bunk, Paul, Chapin, Sarah, Navlakha, Saket, Meyer, Hannah
Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models
8 Dec 2023 | bioRxiv
Loh, Liyen, Carcy, Salomé, Krovi, Harsha, Domenico, Joanne, Spengler, Andrea, Lin, Yong, Torres, Joshua, Palmer, William, Norman, Paul, Stone, Matthew, Brunetti, Tonya, Meyer, Hannah, Gapin, Laurent
copepodTCR: Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling.
29 Nov 2023 | bioRxiv
Kovaleva, Vasilisa, Pattinson, David, Barton, Carl, Chapin, Sarah, Minervina, Anastasia, Richards, Katherine, Sant, Andrea, Thomas, Paul, Pogorelyy, Mikhail, Meyer, Hannah
Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy
9 Aug 2023 | Cell Genomics | 3(8):100347
Kleeman, Sam, Thakir, Tuba, Demestichas, Breanna, Mourikis, Nicholas, Loiero, Dominik, Ferrer, Miriam, Bankier, Sean, Riazat-Kesh, Yosef, Lee, Hassal, Chantzichristos, Dimitrios, Regan, Claire, Preall, Jonathan, Sinha, Sarthak, Rosin, Nicole, Yipp, Bryan, de Almeida, Luiz, Biernaskie, Jeff, Dufour, Antoine, Tober-Lau, Pinkus, Ruusalepp, Arno, Bjorkegren, Johan, Ralser, Markus, Kurth, Florian, Demichev, Vadim, Heywood, Todd, Gao, Qing, Johannsson, Gudmundur, Koelzer, Viktor, Walker, Brian, Meyer, Hannah, Janowitz, Tobias
CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer
15 Jan 2023 | Journal of Pathology
Mou, Haiwei, Eskiocak, Onur, Özler, Kadir, Gorman, Megan, Yue, Junjiayu, Jin, Ying, Wang, Zhikai, Gao, Ya, Janowitz, Tobias, Meyer, Hannah, Yu, Tianxiong, Wilkinson, John, Kucukural, Alper, Ozata, Deniz, Beyaz, Semir
Snakeobjects: an object-oriented workflow management system
12 Dec 2022 | bioRxiv
Yamrom, Boris, Lee, Yoon-ha, Marks, Steven, Chorbadjiev, Lubomir, Meyer, Hannah, Iossifov, Ivan
Cystatin C is associated with adverse COVID-19 outcomes in diverse populations
Oct 2022 | iScience | 25(10):105040
Kleeman, Sam, Cordioli, Mattia, Timmers, Paul, Khan, Atlas, Tober-Lau, Pinkus, Kurth, Florian, Demichev, Vadim, Meyer, Hannah, Wilson, James, Ralser, Markus, Kiryluk, Krzysztof, Ganna, Andrea, Baillie, Kenneth, Janowitz, Tobias
Transcriptomic diversity in human medullary thymic epithelial cells
2 Aug 2022 | Nature Communications | 13(1):4296
Carter, Jason, Strömich, Léonie, Peacey, Matthew, Chapin, Sarah, Velten, Lars, Steinmetz, Lars, Brors, Benedikt, Pinto, Sheena, Meyer, Hannah
Genetic and environmental determinants of diastolic heart function
13 Apr 2022 | Nature Cardiovascular Research | 1(4):361-371
Thanaj, Marjola, Mielke, Johanna, McGurk, Kathryn, Bai, Wenjia, Savioli, Nicolò, de Marvao, Antonio, Meyer, Hannah, Zeng, Lingyao, Sohler, Florian, Lumbers, R, Wilkins, Martin, Ware, James, Bender, Christian, Rueckert, Daniel, MacNamara, Aidan, Freitag, Daniel, O'Regan, Declan
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
15 Sep 2021 | Cell Stem Cell
Beyaz, Semir, Chung, Charlie, Mou, Haiwei, Bauer-Rowe, Khristian, Xifaras, Michael, Ergin, Ilgin, Dohnalova, Lenka, Biton, Moshe, Shekhar, Karthik, Eskiocak, Onur, Papciak, Katherine, Ozler, Kadir, Almeqdadi, Mohammad, Yueh, Brian, Fein, Miriam, Annamalai, Damodaran, Valle-Encinas, Eider, Erdemir, Aysegul, Dogum, Karoline, Shah, Vyom, Alici-Garipcan, Aybuke, Meyer, Hannah, Özata, Deniz, Elinav, Eran, Kucukural, Alper, Kumar, Pawan, McAleer, Jeremy, Fox, James, Thaiss, Christoph, Regev, Aviv, Roper, Jatin, Orkin, Stuart, Yilmaz, Ömer