A properly functioning immune system must be able to recognize diseased cells and foreign invaders among the multitude of healthy cells in the body. This ability is essential to both prevent autoimmune diseases and fight infections and cancer. We study how a specific type of immune cells, known as T cells, are educated to make this distinction during development.
The thymus generates and selects a highly variable yet specific T cell repertoire which discriminates between healthy and non-healthy self and dangerous non-self antigens. My research group uses a systems immunology approach to dissect the mechanisms crucial to the selection processes in the thymus. We develop experimental techniques and combine the resulting data with innovative computational models to generate accurate and testable hypotheses about tissue-level organ physiology.
Studying thymus physiology from a qualitative and quantitative perspective will provide us with a more fine-grained understanding of the selection processes and their down-stream consequences such as auto-immunity, cancer immunosurveillance and immune deficiency.
How does anyone stay healthy in a world full of germs?
January 15, 2021
Computational biology is uncovering the immune system’s tricks for identifying foreign invaders.
New genetic research to understand racial disparity in cancers
September 8, 2020
Cold Spring Harbor Laboratory will study the genetic contributions of ethnicity to colon, endometrial, and pancreas cancers in African Americans.
Understanding the inner workings of the human heart
August 19, 2020
Scientists show that muscular structures first described by Leonardo da Vinci are essential for heart function.
A home like no other, Cold Spring Harbor Laboratory
November 7, 2019
Hear why our campus, our community, and our collaborative nature makes us a place that so many scientists call "home."
Hannah Meyer joins CSHL Quantitative Biology faculty
March 26, 2019
Hannah Meyer is the newest Quantitative Biology Fellow at CSHL, studying how our immune system learns to identify and fight pathogens.