
Hannah Meyer
Assistant Professor
Cancer Center Member
Ph.D., University of Cambridge, EMBL-EBI, 2018
hmeyer@cshl.edu | 516-367-8468
A properly functioning immune system must be able to recognize diseased cells and foreign invaders among the multitude of healthy cells in the body. This ability is essential to both prevent autoimmune diseases and fight infections and cancer. We study how a specific type of immune cells, known as T cells, are educated to make this distinction during development.
The thymus generates and selects a highly variable yet specific T cell repertoire which discriminates between healthy and non-healthy self and dangerous non-self antigens. My research group uses a systems immunology approach to dissect the mechanisms crucial to the selection processes in the thymus. We develop experimental techniques and combine the resulting data with innovative computational models to generate accurate and testable hypotheses about tissue-level organ physiology.
Studying thymus physiology from a qualitative and quantitative perspective will provide us with a more fine-grained understanding of the selection processes and their down-stream consequences such as auto-immunity, cancer immunosurveillance and immune deficiency.
How the thymus trains T cells to fight infections
August 2, 2022
CSHL scientists identified, for the first time, the RNA in humans used to train T cells to attack dangerous or foreign proteins in the body.
CSHL Fellow Hannah Meyer wins UK Biobank researcher award
November 17, 2021
The UK Biobank recognized CSHL Fellow Hannah Meyer’s scientific achievements in understanding the inner workings of the human heart.
Team PE Revival wins CSHL volleyball championship
September 29, 2021
Team PE Revival won the thirtieth annual CSHL beach volleyball tournament by winning two out of three matches.
Local Regeneron scholars celebrated by Congressman Suozzi
March 5, 2021
Over twenty local high school students were named scholars in the Regeneron Science Talent Search national competition and awarded $2,000 scholarships.
How does anyone stay healthy in a world full of germs?
January 15, 2021
Computational biology is uncovering the immune system’s tricks for identifying foreign invaders.
New genetic research to understand racial disparity in cancers
September 8, 2020
Cold Spring Harbor Laboratory will study the genetic contributions of ethnicity to colon, endometrial, and pancreas cancers in African Americans.
Understanding the inner workings of the human heart
August 19, 2020
Scientists show that muscular structures first described by Leonardo da Vinci are essential for heart function.
A home like no other, Cold Spring Harbor Laboratory
November 7, 2019
Hear why our campus, our community, and our collaborative nature makes us a place that so many scientists call "home."
Hannah Meyer joins CSHL Quantitative Biology faculty
March 26, 2019
Hannah Meyer is the newest Quantitative Biology Fellow at CSHL, studying how our immune system learns to identify and fight pathogens.
All Publications
CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer
15 Jan 2023 | Journal of Pathology
Mou, Haiwei, Eskiocak, Onur, Özler, Kadir, Gorman, Megan, Yue, Junjiayu, Jin, Ying, Wang, Zhikai, Gao, Ya, Janowitz, Tobias, Meyer, Hannah, Yu, Tianxiong, Wilkinson, John, Kucukural, Alper, Ozata, Deniz, Beyaz, Semir
Cystatin C is associated with adverse COVID-19 outcomes in diverse populations
Oct 2022 | iScience | 25(10):105040
Kleeman, Sam, Cordioli, Mattia, Timmers, Paul, Khan, Atlas, Tober-Lau, Pinkus, Kurth, Florian, Demichev, Vadim, Meyer, Hannah, Wilson, James, Ralser, Markus, Kiryluk, Krzysztof, Ganna, Andrea, Baillie, Kenneth, Janowitz, Tobias
Transcriptomic diversity in human medullary thymic epithelial cells
2 Aug 2022 | Nature Communications | 13(1):4296
Carter, Jason, Strömich, Léonie, Peacey, Matthew, Chapin, Sarah, Velten, Lars, Steinmetz, Lars, Brors, Benedikt, Pinto, Sheena, Meyer, Hannah
Genetic and environmental determinants of diastolic heart function
13 Apr 2022 | Nature Cardiovascular Research | 1(4):361-371
Thanaj, Marjola, Mielke, Johanna, McGurk, Kathryn, Bai, Wenjia, Savioli, Nicolò, de Marvao, Antonio, Meyer, Hannah, Zeng, Lingyao, Sohler, Florian, Lumbers, R, Wilkins, Martin, Ware, James, Bender, Christian, Rueckert, Daniel, MacNamara, Aidan, Freitag, Daniel, O'Regan, Declan
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
15 Sep 2021 | Cell Stem Cell
Beyaz, Semir, Chung, Charlie, Mou, Haiwei, Bauer-Rowe, Khristian, Xifaras, Michael, Ergin, Ilgin, Dohnalova, Lenka, Biton, Moshe, Shekhar, Karthik, Eskiocak, Onur, Papciak, Katherine, Ozler, Kadir, Almeqdadi, Mohammad, Yueh, Brian, Fein, Miriam, Annamalai, Damodaran, Valle-Encinas, Eider, Erdemir, Aysegul, Dogum, Karoline, Shah, Vyom, Alici-Garipcan, Aybuke, Meyer, Hannah, Özata, Deniz, Elinav, Eran, Kucukural, Alper, Kumar, Pawan, McAleer, Jeremy, Fox, James, Thaiss, Christoph, Regev, Aviv, Roper, Jatin, Orkin, Stuart, Yilmaz, Ömer
CamGFR v2: A New Model for Estimating the Glomerular Filtration Rate from Standardized or Non-standardized Creatinine in Patients with Cancer.
1 Mar 2021 | Clinical Cancer Research | 27(5):1381-1390
Williams, Edward, Flint, Thomas, Connell, Claire, Giglio, Daniel, Lee, Hassal, Ha, Taehoon, Gablenz, Eva, Bird, Nicholas, Weaver, James, Potts, Harry, Whitley, Cameron, Bookman, Michael, Lynch, Andy, Meyer, Hannah, Tavaré, Simon, Janowitz, Tobias
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis
8 Sep 2020 | BioRxiv
Beyaz, S, Roper, J, Bauer-Rowe, K, Xifaras, M, Ergin, I, Dohnalova, L, Biton, M, Shekar, K, Mou, H, Eskiocak, O, Ozata, D, Papciak, K, Chung, C, Almeqdadi, M, Fein, M, Valle-Encinas, E, Erdemir, A, Dogum, K, Garipcan, A, Meyer, H, Fox, J, Elinav, E, Kucukural, A, Kumar, P, McAleer, J, Thaiss, C, Regev, A, Orkin, S, Yilmaz, O
Genetic and functional insights into the fractal structure of the heart
Aug 2020 | Nature | 584(7822):589-594
Meyer, H, Dawes, T, Serrani, M, Bai, W, Tokarczuk, P, Cai, J, de Marvao, A, Henry, A, Lumbers, R, Gierten, J, Thumberger, T, Wittbrodt, J, Ware, J, Rueckert, D, Matthews, P, Prasad, S, Costantino, M, Cook, S, Birney, E, O'Regan, D
Genomic analysis reveals a functional role for myocardial trabeculae in adults
1 Mar 2019 | bioRxiv | :553651
Meyer, Hannah, Dawes, Timothy, Serrani, Marta, Bai, Wenjia, Tokarczuk, Pawel, Cai, Jiashen, de Marvao, Antonio, Rueckert, Daniel, Matthews, Paul, Costantino, Maria, Birney, Ewan, Cook, Stuart, O'Regan, Declan
PhenotypeSimulator: A comprehensive framework for simulating multi-trait, multi-locus genotype to phenotype relationships
1 Sep 2018 | Bioinformatics | 34(17):2951-2956
Meyer, H, Birney, E