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Hannah Meyer

Hannah Meyer

Assistant Professor
Cancer Center Member

Ph.D., University of Cambridge, EMBL-EBI, 2018

hmeyer@cshl.edu | 516-367-8468

Meyer Lab Website   Faculty Profile

A properly functioning immune system must be able to recognize diseased cells and foreign invaders among the multitude of healthy cells in the body. This ability is essential to both prevent autoimmune diseases and fight infections and cancer. We study how a specific type of immune cells, known as T cells, are educated to make this distinction during development.

The thymus generates and selects a highly variable yet specific T cell repertoire which discriminates between healthy and non-healthy self and dangerous non-self antigens. My research group uses a systems immunology approach to dissect the mechanisms crucial to the selection processes in the thymus. We develop experimental techniques and combine the resulting data with innovative computational models to generate accurate and testable hypotheses about tissue-level organ physiology.

Studying thymus physiology from a qualitative and quantitative perspective will provide us with a more fine-grained understanding of the selection processes and their down-stream consequences such as auto-immunity, cancer immunosurveillance and immune deficiency.

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All Publications

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer

15 Jan 2023 | Journal of Pathology
Mou, Haiwei, Eskiocak, Onur, Özler, Kadir, Gorman, Megan, Yue, Junjiayu, Jin, Ying, Wang, Zhikai, Gao, Ya, Janowitz, Tobias, Meyer, Hannah, Yu, Tianxiong, Wilkinson, John, Kucukural, Alper, Ozata, Deniz, Beyaz, Semir

Cystatin C is associated with adverse COVID-19 outcomes in diverse populations

Oct 2022 | iScience | 25(10):105040
Kleeman, Sam, Cordioli, Mattia, Timmers, Paul, Khan, Atlas, Tober-Lau, Pinkus, Kurth, Florian, Demichev, Vadim, Meyer, Hannah, Wilson, James, Ralser, Markus, Kiryluk, Krzysztof, Ganna, Andrea, Baillie, Kenneth, Janowitz, Tobias

Transcriptomic diversity in human medullary thymic epithelial cells

2 Aug 2022 | Nature Communications | 13(1):4296
Carter, Jason, Strömich, Léonie, Peacey, Matthew, Chapin, Sarah, Velten, Lars, Steinmetz, Lars, Brors, Benedikt, Pinto, Sheena, Meyer, Hannah

Genetic and environmental determinants of diastolic heart function

13 Apr 2022 | Nature Cardiovascular Research | 1(4):361-371
Thanaj, Marjola, Mielke, Johanna, McGurk, Kathryn, Bai, Wenjia, Savioli, Nicolò, de Marvao, Antonio, Meyer, Hannah, Zeng, Lingyao, Sohler, Florian, Lumbers, R, Wilkins, Martin, Ware, James, Bender, Christian, Rueckert, Daniel, MacNamara, Aidan, Freitag, Daniel, O'Regan, Declan

Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

15 Sep 2021 | Cell Stem Cell
Beyaz, Semir, Chung, Charlie, Mou, Haiwei, Bauer-Rowe, Khristian, Xifaras, Michael, Ergin, Ilgin, Dohnalova, Lenka, Biton, Moshe, Shekhar, Karthik, Eskiocak, Onur, Papciak, Katherine, Ozler, Kadir, Almeqdadi, Mohammad, Yueh, Brian, Fein, Miriam, Annamalai, Damodaran, Valle-Encinas, Eider, Erdemir, Aysegul, Dogum, Karoline, Shah, Vyom, Alici-Garipcan, Aybuke, Meyer, Hannah, Özata, Deniz, Elinav, Eran, Kucukural, Alper, Kumar, Pawan, McAleer, Jeremy, Fox, James, Thaiss, Christoph, Regev, Aviv, Roper, Jatin, Orkin, Stuart, Yilmaz, Ömer

CamGFR v2: A New Model for Estimating the Glomerular Filtration Rate from Standardized or Non-standardized Creatinine in Patients with Cancer.

1 Mar 2021 | Clinical Cancer Research | 27(5):1381-1390
Williams, Edward, Flint, Thomas, Connell, Claire, Giglio, Daniel, Lee, Hassal, Ha, Taehoon, Gablenz, Eva, Bird, Nicholas, Weaver, James, Potts, Harry, Whitley, Cameron, Bookman, Michael, Lynch, Andy, Meyer, Hannah, Tavaré, Simon, Janowitz, Tobias

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

8 Sep 2020 | BioRxiv
Beyaz, S, Roper, J, Bauer-Rowe, K, Xifaras, M, Ergin, I, Dohnalova, L, Biton, M, Shekar, K, Mou, H, Eskiocak, O, Ozata, D, Papciak, K, Chung, C, Almeqdadi, M, Fein, M, Valle-Encinas, E, Erdemir, A, Dogum, K, Garipcan, A, Meyer, H, Fox, J, Elinav, E, Kucukural, A, Kumar, P, McAleer, J, Thaiss, C, Regev, A, Orkin, S, Yilmaz, O

Genetic and functional insights into the fractal structure of the heart

Aug 2020 | Nature | 584(7822):589-594
Meyer, H, Dawes, T, Serrani, M, Bai, W, Tokarczuk, P, Cai, J, de Marvao, A, Henry, A, Lumbers, R, Gierten, J, Thumberger, T, Wittbrodt, J, Ware, J, Rueckert, D, Matthews, P, Prasad, S, Costantino, M, Cook, S, Birney, E, O'Regan, D

Genomic analysis reveals a functional role for myocardial trabeculae in adults

1 Mar 2019 | bioRxiv | :553651
Meyer, Hannah, Dawes, Timothy, Serrani, Marta, Bai, Wenjia, Tokarczuk, Pawel, Cai, Jiashen, de Marvao, Antonio, Rueckert, Daniel, Matthews, Paul, Costantino, Maria, Birney, Ewan, Cook, Stuart, O'Regan, Declan

PhenotypeSimulator: A comprehensive framework for simulating multi-trait, multi-locus genotype to phenotype relationships

1 Sep 2018 | Bioinformatics | 34(17):2951-2956
Meyer, H, Birney, E

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