My lab studies genes and signals in cells that regulate the growth and shape of plants. We have discovered several genes that control plant architecture by exerting an influence on stem cells. By identifying the genes that control the number of stem cells in corn plants, for example, we’ve discovered a means of boosting the yield of that vital staple.
David Jackson and colleagues study genes and signals that regulate plant growth and architecture. They are investigating a unique way in which plant cells communicate, by transporting regulatory proteins via small channels called plasmodesmata. These channels, which direct the flow of nutrients and signals through growing tissues, are regulated during development. The team discovered a gene encoding a chaperonin, CCT8, that controls the transport of a transcription factor SHOOTMERISTEMLESS (STM) between cells in the plant stem cell niche, or meristem. STM is critical for stem cell maintenance, and studies of the CCT8 gene indicate that movement of STM between cells is required for this function. The lab also continues to identify other genes that control plant architecture through effects on stem cell maintenance and identity, and their work has implications for crop yields. Recent examples include discovery of a subunit of a heterotrimeric G protein that is conserved throughout animals and plants, and their studies indicate that this gene controls stem cell proliferation. They have found that in plants, the G protein interacts with a completely different class of receptors than in animals. Their discovery helps to explain how signaling from diverse receptors is achieved in plants. This year, they also demonstrated that weak mutations in one of the receptor proteins can enhance seed production in maize, which could lead to yield increases. Separately, the lab has characterized system-wide networks of gene expression, using “next-gen” profiling and chromatin immunoprecipitation methods that have revealed many new hypotheses in developmental networks controlling inflorescence development. They are also developing a collection of maize lines that can drive expression of any reporter or experimental gene in any tissue type—tools of great interest to maize researchers that are being made available to the broader scientific community, enabling experiments never before possible in crop plants.
Bommert, P. and Je, B. I. and Goldshmidt, A. and Jackson, D. (2013) The maize G alpha gene COMPACT PLANT2 functions in CLAVATA signalling to control shoot meristem size. Nature, 502(7472) pp. 555-558.
Bommert, P. and Nagasawa, N. S. and Jackson, D. (2013) Quantitative variation in maize kernel row number is controlled by the FASCIATED EAR2 locus. Nature Genetics, 45(3) pp. 334-337.
Xu, X. M. and Wang, J. and Xuan, Z. Y. and Goldshmidt, A. and Borrill, P. G. M. and Hariharan, N. and Kim, J. Y. and Jackson, D. P. (2011) Chaperonins Facilitate KNOTTED1 Cell-to-Cell Trafficking and Stem Cell Function. Science, 333(6046) pp. 1141-1144.
Whipple, C. J. and Kebrom, T. H. and Weber, A. L. and Yang, F. and Hall, D. and Meeley, R. and Schmidt, R. and Doebley, J. and Brutnell, T. P. and Jackson, D. P. (2011) grassy tillers1 promotes apical dominance in maize and responds to shade signals in the grasses. Proceedings of the National Academy of Sciences of the United States of America, 108(33) pp. E506-E512.
Satoh-Nagasawa, N. and Nagasawa, N. and Malcomber, S. and Sakai, H. and Jackson, D. (2006) A trehalose metabolic enzyme controls inflorescence architecture in maize. Nature, 441(7090) pp. 227-30.Additional materials of the author at
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