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Camila dos Santos

Camila dos Santos

Associate Professor
Cancer Center Associate Director of DEI

Ph.D., Universidade Estadual de Campinas - Brazil, 2007

dossanto@cshl.edu | 516-367-8869

dos Santos Lab Website   Faculty Profile

Among the changes that occur during pregnancy, those affecting the breasts have been found to subsequently modify breast cancer risk. My laboratory investigates how the signals present during pregnancy permanently alter the way gene expression is controlled and how these changes affect normal and malignant mammary development.

Camila dos Santos’ laboratory studies the epigenetic regulation of normal and malignant mammary gland development, with an emphasis on the alterations brought by pregnancy. Significant changes mark the pre- and post-pubescence mammary developmental stages, but those associated with pregnancy have the greatest effect on cellular function, tissue reorganization, and breast cancer susceptibility. Her group has recently found that mammary glands react differently to a second pregnancy than they do to the first one, with associated changes in DNA methylation. These findings suggested that pregnancy changes the state of mammary cells, and these may permanently alter how they react to the next pregnancy. In addition, the dos Santos lab is exploring how the pregnancy-induced epigenetic changes might influence cell transformation and the risk of breast cancer. This research utilizes genomic and computational approaches to define the pre and post-pregnancy mammary epigenome. An additional objective of the dos Santos’ laboratory is to use functional genomics to discover novel transcriptional regulators that modulate mammary stem cell self-renewal, lineage specification, and cell transformation. The long-term objective of Camila’s group is to improve the notion of the mammary epigenome during normal development and use this information to gain insight into new preventive and curative strategies to target breast cancer.

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All Publications

Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma

17 Jun 2024 | Nature Genetics
Maia-Silva, Diogo, Cunniff, Patrick, Schier, Allison, Skopelitis, Damianos, Trousdell, Marygrace, Moresco, Philip, Gao, Yuan, Kechejian, Vahag, He, Xue-Yan, Sahin, Yunus, Wan, Ledong, Alpsoy, Aktan, Liverpool, Jynelle, Krainer, Adrian, Egeblad, Mikala, Spector, David, Fearon, Douglas, Dos Santos, Camila, Taatjes, Dylan, Vakoc, Christopher

Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1

16 Apr 2024 | Nature Communications | 15(1):3282
Henry, Samantha, Lewis, Steven, Cyrill, Samantha, Callaway, Mackenzie, Chatterjee, Deeptiman, Hanasoge Somasundara, Amritha, Jones, Gina, He, Xue-Yan, Caligiuri, Giuseppina, Ciccone, Michael, Diaz, Isabella, Biswas, Amelia, Hernandez, Evelyn, Ha, Taehoon, Wilkinson, John, Egeblad, Mikala, Tuveson, David, Dos Santos, Camila

Host response during unresolved urinary tract infection alters mammary tissue homeostasis through collagen deposition and TIMP1

6 Feb 2024 | bioRxiv
Henry, Samantha, Lewis, Steven, Cyrill, Samantha, Callaway, Mackenzie, Chatterjee, Deeptiman, Hanasoge Somasundara, Amritha, Jones, Gina, He, Xue-Yan, Caligiuri, Giuseppina, Ciccone, Michael, Diaz, Isabella, Biswas, Amelia, Hernandez, Evelyn, Ha, Taehoon, Wilkinson, John, Egeblad, Mikala, Tuveson, David, Oresco dos Santos, Camila

Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones

30 Jan 2024 | Journal of Mammary Gland Biology and Neoplasia | 29(1):3
Ortiz, Jenelys, Lewis, Steven, Ciccone, Michael, Chatterjee, Deeptiman, Henry, Samantha, Siepel, Adam, Dos Santos, Camila

Single-cell transcription mapping of murine and human mammary organoids responses to female hormones

29 Sep 2023 | bioRxiv
Ortiz, Jenelys, Lewis, Steven, Ciccone, Michael, Chatterjee, Deeptiman, Henry, Samantha, Siepel, Adam, Dos Santos, Camila

Gestational Breast Cancer - a Review of Outcomes, Pathophysiology, and Model Systems

14 Jul 2023 | Journal of Mammary Gland Biology and Neoplasia | 28(1):16
Callaway, Mackenzie, Dos Santos, Camila

Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line

7 Jul 2023 | International Journal of Molecular Sciences | 24(13):11215
Costa, Iris, Effer, Brian, Costa-Silva, Tales, Chen, Chen, Ciccone, Michael, Pessoa, Adalberto, Dos Santos, Camila, Monteiro, Gisele

Immature natural killer cells promote progression of triple-negative breast cancer

8 Mar 2023 | Science Translational Medicine | 15(686):eabl4414
Thacker, Gatha, Henry, Samantha, Nandi, Ajeya, Debnath, Rahul, Singh, Snahlata, Nayak, Anupma, Susnik, Barbara, Boone, Melinda, Zhang, Qing, Kesmodel, Susan, Gumber, Sanjeev, Das, Gokul, Kambayashi, Taku, Dos Santos, Camila, Chakrabarti, Rumela

Clinical applications of 3D normal and breast cancer organoids: A review of concepts and methods

19 Nov 2022 | Experimental Biology and Medicine | :15353702221131877
Lewis, Steven, Callaway, Mackenzie, Dos Santos, Camila

Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis

7 Dec 2021 | Cell Reports | 37(10):110099
Hanasoge Somasundara, Amritha, Moss, Matthew, Feigman, Mary, Chen, Chen, Cyrill, Samantha, Ciccone, Michael, Trousdell, Marygrace, Vollbrecht, Macy, Li, Siran, Kendall, Jude, Beyaz, Semir, Wilkinson, John, Dos Santos, Camila

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