Zachary Lippman

Zachary Lippman

Professor & HHMI Investigator
Jacob Goldfield Professor of Genetics

Ph.D., Watson School of Biological Sciences at Cold Spring Harbor Laboratory, 2004

lippman@cshl.edu | 516-367-8897

Lippman Lab Website  

My research team studies the genes that determine when and where, and thus how many, flowers are produced on plants. Flowers form on branches called inflorescences, which originate from stem cells. By studying the genes that control how stem cells become inflorescences, we are able to manipulate flower production to improve crop yields.

Zachary Lippman’s research focuses on the process of flowering and flower production in plants, which are major contributors to reproductive success and crop yield. Specifically, Lippman’s research program integrates development, genetics, genomics, and gene editing to explore the mechanisms that determine how plant stem cells become shoots and flowers. The lab takes advantage of extensive natural and mutant variation in inflorescence production and architecture in tomato and related nightshade species (e.g. potato, pepper, groundcherry) to explore how differences in these processes explain the remarkable diversity in the architectures of flower-bearing shoots (inflorescences) observed in nature and agriculture. Recent discoveries on the genes and networks underlying this diversity have led to broader questions on the significance of genomic structural variation, gene redundancy, and epistasis in development, domestication, and breeding. Based on our fundamental discoveries, Lippman is developing and applying innovative concepts and tools for crop improvement.

Kwon, C. T. and Heo, J. and Lemmon, Z. H. and Capua, Y. and Hutton, S. F. and Van Eck, J. and Park, S. J. and Lippman, Z. B. (2019) Rapid customization of Solanaceae fruit crops for urban agriculture. Nat Biotechnol, 38 pp. 182-188.

Eshed, Y. and Lippman, Z. B. (2019) Revolutions in agriculture chart a course for targeted breeding of old and new crops. Science, 366(6466)

Soyk, S. and Lemmon, Z. H. and Sedlazeck, F. J. and Jimenez-Gomez, J. M. and Alonge, M. and Hutton, S. F. and Van Eck, J. and Schatz, M. C. and Lippman, Z. B. (2019) Duplication of a domestication locus neutralized a cryptic variant that caused a breeding barrier in tomato. Nat Plants, 5(5) pp. 471-497.

Additional materials of the author at
CSHL Institutional Repository