Zachary Lippman

Zachary Lippman

Professor & HHMI Investigator
Jacob Goldfield Professor of Genetics

Ph.D., Watson School of Biological Sciences at Cold Spring Harbor Laboratory, 2004

lippman@cshl.edu | 516-367-8897

Lippman Lab Website  

My research team studies the genes that determine when and where, and thus how many, flowers are produced on plants. Flowers form on branches called inflorescences, which originate from stem cells. By studying the genes that control how stem cells become inflorescences, we are able to manipulate flower production to improve crop yields.

Zachary Lippman’s research focuses on the process of flowering and flower production in plants, which are major contributors to reproductive success and crop yield. Specifically, Lippman’s research program integrates development, genetics, genomics, and gene editing to explore the mechanisms that determine how plant stem cells become shoots and flowers. The lab takes advantage of extensive natural and mutant variation in inflorescence production and architecture in tomato and related nightshade species (e.g. potato, pepper, groundcherry) to explore how differences in these processes explain the remarkable diversity in the architectures of flower-bearing shoots (inflorescences) observed in nature and agriculture. Recent discoveries on the genes and networks underlying this diversity have led to broader questions on the significance of genomic structural variation, gene redundancy, and epistasis in development, domestication, and breeding. Based on our fundamental discoveries, Lippman is developing and applying innovative concepts and tools for crop improvement.

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Selected Publications

Rapid customization of Solanaceae fruit crops for urban agriculture

23 Dec 2019 | Nature Biotechnology | 38:182-188
Kwon, C, Heo, J, Lemmon, Z, Capua, Y, Hutton, S, Van Eck, J, Park, S, Lippman, Z

Revolutions in agriculture chart a course for targeted breeding of old and new crops

5 Sep 2019 | Science | 366(6466)
Eshed, Y, Lippman, Z

Duplication of a domestication locus neutralized a cryptic variant that caused a breeding barrier in tomato

6 May 2019 | Nature Plants | 5(5):471-497
Soyk, S, Lemmon, Z, Sedlazeck, F, Jimenez-Gomez, J, Alonge, M, Hutton, S, Van Eck, J, Schatz, M, Lippman, Z

All Publications

Dynamic evolution of small signalling peptide compensation in plant stem cell control

28 Mar 2022 | Nature Plants
Kwon, Choon-Tak, Tang, Lingli, Wang, Xingang, Gentile, Iacopo, Hendelman, Anat, Robitaille, Gina, Van Eck, Joyce, Xu, Cao, Lippman, Zachary

Automated assembly scaffolding elevates a new tomato system for high-throughput genome editing

19 Nov 2021 | bioRxiv
Alonge, Michael, Lebeigle, Ludivine, Kirsche, Melanie, Aganezov, Sergey, Wang, Xingang, Lippman, Zachary, Schatz, Michael, Soyk, Sebastian

Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection.

1 Apr 2021 | Cell | 184(7):1724-1739.e16
Hendelman, Anat, Zebell, Sophia, Rodriguez-Leal, Daniel, Dukler, Noah, Robitaille, Gina, Wu, Xuelin, Kostyun, Jamie, Tal, Lior, Wang, Peipei, Bartlett, Madelaine, Eshed, Yuval, Efroni, Idan, Lippman, Zachary

Dissecting cis-regulatory control of quantitative trait variation in a plant stem cell circuit.

Apr 2021 | Nature Plants | 7(4):419-427
Wang, Xingang, Aguirre, Lyndsey, Rodríguez-Leal, Daniel, Hendelman, Anat, Benoit, Matthias, Lippman, Zachary

Optimized sample selection for cost-efficient long-read population sequencing.

May 2021 | Genome Research | 31(5):910-918
Ranallo-Benavidez, T, Lemmon, Zachary, Soyk, Sebastian, Aganezov, Sergey, Salerno, William, McCoy, Rajiv, Lippman, Zachary, Schatz, Michael, Sedlazeck, Fritz

A review of nutritional properties and health benefits of Physalis species

Sep 2020 | Plant Foods for Human Nutrition | 75(3):316-325
Shenstone, E, Lippman, Z, Van Eck, J

New Horizons for Dissecting Epistasis in Crop Quantitative Trait Variation

1 Sep 2020 | Annual Review of Genetics | 54:287-307
Soyk, S, Benoit, M, Lippman, Z