Cancer Center Member
Ph.D., Harvard University, 2017
firstname.lastname@example.org | 516-367-4128Faculty Profile
Are you really what you eat? Our goal is to uncover the precise mechanisms that link nutrition to organismal health and disease states at the cellular and molecular level. A particular focus in our lab is to understand how dietary perturbations affect the immune system and contribute to the risk of diseases that are associated with immune dysfunction such as cancer.
Cells respond and adapt to the signals that they receive from their environment. Environmental factors such as nutrients affect cellular states by altering cell state-specific gene expression or metabolic programs. My research group investigates the causal cellular and molecular mechanisms that link nutrition to organismal health and disease. For example, diets that lead to obesity, such as high fat diets are significant environmental risk factors that influence cancer incidence and progression in several tissues. Although the interactions between tumor cells and the immune system play a significant role in tumorigenesis, little is known about how dietary perturbations impact immunity against cancer. Our studies interrogate the functional consequences of diets on immune recognition and response pathways that play critical role in cancer immunity. By identifying the altered gene expression and metabolic programs in the immune system in response to dietary perturbations, our goal is to uncover mechanistic links that can be therapeutically exploited for the treatment of diseases associated with immune dysfunction such as cancer.
CSHL Fellow Semir Beyaz wins three awards
The Janeway Award, New England Immunology Conference
Trainee Award, American Association of Immunologists
Outstanding Poster Award, International Society for Stem Cell Research
Zhongmei Chen Yong Travel Award for Scientific Excellence, International Society for Stem Cell Research
Merit Award, International Society for Stem Cell Research
Thermo-Fisher Trainee Achievement Award, American Association of Immunologists
President’s essay: Bringing bold visions to life
May 26, 2023
CSHL President & CEO Bruce Stillman sees the Laboratory as a global hub for scientific expertise and a powerful launchpad for early-career scientists.
The CSHL School of Biological Sciences’ class of 2023
May 7, 2023
The School of Biological Sciences awarded 11 Ph.D. degrees this year. Here, the graduates reflect on their time and experiences at CSHL.
Your diet is your future
May 3, 2023
In this video, CSHL Assistant Professor Semir Beyaz shows how what you eat continues to influence your health long after you’ve digested it.
Identifying cancer genes’ multiple personalities
April 10, 2023
The same genes can cause different subtypes of tumors. Now, CSHL can recreate them in the lab. The approach could lead to new cancer treatments.
Cold Spring Harbor Laboratory: Foundations for the Future
December 15, 2022
CSHL continues to lead in biomedical sciences by fostering a collaborative, innovative, and high-risk, high-reward research community.
Defining cells across diverse ancestries
November 17, 2021
CSHL Fellow Semir Beyaz is leading a multi-institutional effort to explore how genetic ancestry influences health and disease in the uterus.
How high-fat diets allow cancer cells to go unnoticed
September 28, 2021
Too much fat in diets can weaken the ability of the immune system to recognize and destroy intestinal cancer cells.
Local Regeneron scholars celebrated by Congressman Suozzi
March 5, 2021
Over twenty local high school students were named scholars in the Regeneron Science Talent Search national competition and awarded $2,000 scholarships.
Partner for the Future named 2021 Regeneron scholar
January 28, 2021
Jericho High School student Vyom Shah was named a Regeneron scholar for his work in CSHL Fellow Semir Beyaz’s lab.
How does anyone stay healthy in a world full of germs?
January 15, 2021
Computational biology is uncovering the immune system’s tricks for identifying foreign invaders.
Study: High-Fat Diets May Raise Cancer Risk
High-fat diets increase risk of tumors forming in the gut, say scientists
How A High-Fat Diet Can Increase Cancer Risk
High-fat diet activates a PPAR-δ program to enhance intestinal stem cell function.
1 Apr 2021 | Cell Stem Cell | 28(4):598-599
Beyaz, Semir, Mana, Miyeko, Yilmaz, Ömer
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity
15 Oct 2020 | Mucosal Immunology
Gaudino, S, Beaupre, M, Lin, X, Joshi, P, Rathi, S, McLaughlin, P, Kempen, C, Mehta, N, Eskiocak, O, Yueh, B, Blumberg, R, van der Velden, A, Shroyer, K, Bialkowska, A, Beyaz, S, Kumar, P
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis
8 Sep 2020 | BioRxiv
Beyaz, S, Roper, J, Bauer-Rowe, K, Xifaras, M, Ergin, I, Dohnalova, L, Biton, M, Shekar, K, Mou, H, Eskiocak, O, Ozata, D, Papciak, K, Chung, C, Almeqdadi, M, Fein, M, Valle-Encinas, E, Erdemir, A, Dogum, K, Garipcan, A, Meyer, H, Fox, J, Elinav, E, Kucukural, A, Kumar, P, McAleer, J, Thaiss, C, Regev, A, Orkin, S, Yilmaz, O
Distribution and storage of inflammatory memory in barrier tissues
3 Feb 2020 | Nature Reviews Immunology | 20(5):308-320
Ordovas-Montanes, J, Beyaz, S, Rakoff-Nahoum, S, Shalek, A
Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet
25 Jul 2019 | Gastroenterology | 157(5)
Luo, Y, Yang, Y, Liu, M, Wang, D, Wang, F, Bi, Y, Ji, J, Li, S, Liu, Y, Chen, R, Huang, H, Wang, X, Swidnicka-Siergiejko, A, Janowitz, T, Beyaz, S, Wang, G, Xu, S, Bialkowska, A, Luo, C, Pin, C, Liang, G, Lu, X, Wu, M, Shroyer, K, Wolff, R, Plunkett, W, Ji, B, Li, Z, Li, E, Li, X, Yang, V, Logsdon, C, Abbruzzese, J, Lu, W
Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.
May 2023 | Annals of the New York Academy of Sciences | 1523(1):38-50
Cable, Jennifer, Rathmell, Jeffrey, Pearce, Erika, Ho, Ping-Chih, Haigis, Marcia, Mamedov, Murad, Wu, Meng-Ju, Kaech, Susan, Lynch, Lydia, Febbraio, Mark, Bapat, Sagar, Hong, Hanna, Zou, Weiping, Belkaid, Yasmine, Sullivan, Zuri, Keller, Andrea, Wculek, Stefanie, Green, Douglas, Postic, Catherine, Amit, Ido, Benitah, Salvador, Jones, Russell, Reina-Campos, Miguel, Torres, Santiago, Beyaz, Semir, Brennan, Donal, O'Neill, Luke, Perry, Rachel, Brenner, Dirk
CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer
15 Jan 2023 | Journal of Pathology
Mou, Haiwei, Eskiocak, Onur, Özler, Kadir, Gorman, Megan, Yue, Junjiayu, Jin, Ying, Wang, Zhikai, Gao, Ya, Janowitz, Tobias, Meyer, Hannah, Yu, Tianxiong, Wilkinson, John, Kucukural, Alper, Ozata, Deniz, Beyaz, Semir
Establishing patient-derived organoids from human endometrial cancer and normal endometrium.
2023 | Frontiers in Endocrinology | 14:1059228
Katcher, Arielle, Yueh, Brian, Ozler, Kadir, Nizam, Aaron, Kredentser, Ariel, Chung, Charlie, Frimer, Marina, Goldberg, Gary, Beyaz, Semir
Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis
20 Oct 2022 | Nature Neuroscience
Furlan, Alessandro, Corona, Alberto, Boyle, Sara, Sharma, Radhashree, Rubino, Rachel, Habel, Jill, Gablenz, Eva, Giovanniello, Jacqueline, Beyaz, Semir, Janowitz, Tobias, Shea, Stephen, Li, Bo
Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
May 2022 | PLoS Pathogens | 18(5):e1010586
Chu, Timothy, Khairallah, Camille, Shieh, Jason, Cho, Rhea, Qiu, Zhijuan, Zhang, Yue, Eskiocak, Onur, Thanassi, David, Kaplan, Mark, Beyaz, Semir, Yang, Vincent, Bliska, James, Sheridan, Brian