Sara Goodwin
Research Assistant Professor and Director, Sequencing Technologies and Analysis
Ph.D, The University of Texas at Austin, 2013
sgoodwin@cshl.edu | 516-422-4153
I work on adapting and developing new methods/techniques for genome and transcriptome sequencing.
My research interests lie at the intersection of genomics, sequencing technology development, and its diverse applications in biological problem-solving. Throughout my tenure at Cold Spring Harbor Laboratory, I’ve dedicated myself to enhancing sequencing methodologies including for complex genome de novo sequencing and assembly on the PacBio and Oxford Nanopore platforms. Notably, I contributed to the development of pipelines to increase the usability and accuracy of PacBio sequencing, culminating in the high-coverage sequencing of the SK-BR-3 breast cancer cell line. I have pioneered de novo sequencing strategies on the Oxford Nanopore MinION, achieving superior assembly consensus and contiguity of many genomes across several Kingdoms. My work has additionally supported research into cancer genomics such as sparse sequencing applications in Acute Myeloid Leukemia and long-read sequencing to discover photogenic variants in colorectal, testicular, and breast cancer.