Animal & Tissue Imaging

Animal Tissue Imaging

The Animal Imaging & Tissue Imaging Shared Resource provides both expertise and access to state-of-the-art non-invasive imaging modalities, tissue imaging, and pathology. This Resource allows researchers to visualize a broad range of tumor- associated parameters without invasive or terminal procedures, obtain high quality tissue sections, and access extensive pathology services. For more information, see below or contact the Resource Director, Peter Westcott.

Explore all the CSHL Core Facilities

Shared Resource Staff

Resource Head

Peter Westcott, Ph.D.

Animal Imaging

Scott Lyons, Ph.D., Director

Research Technologists
Joseph Merrill merrill@cshl.edu
Libia Garcia ligarcia@cshl.edu

Tissue Imaging

Qing Gao, Ph.D., M.D, Manager

Research Technologists
Denise Cahn dhoppe@cshl.edu
Kristin Milicich kmilicic@cshl.edu

Non-invasive in vivo imaging has become increasingly important in conducting research with cancer models, as it enables the researcher to visualize and measure a broad range of tumor-associated parameters without invasive or terminal procedures. This Shared Resource offers:

Imaging modalities offered

  • Optical imaging, bioluminescence and fluorescence (IVIS Spectrum, Perkin Elmer)
  • Ultrasound imaging (Vevo3100, Visualsonics)
  • PET imaging (Positron Emission Tomography, Nanoscan scanner, Mediso USA)
  • SPECT imaging (Single Photon Emission Computed Tomography, Nanoscan scanner, Mediso USA)
  • CT imaging (Computed Tomography, Nanoscan scanner, Mediso USA)

The Animal & Tissue Imaging Shared Resource provides a spectrum of histopathological services, including:

  • Tissue sampling and fixation
  • Paraffin or frozen tissue embedding and sectioning
  • Hematoxylin and Eosin staining and special staining, i.e., Masson trichrome and Alcian blue.
  • Immunohistochemistry (IHC), including multiple IHC
  • Bright-field and fluorescence whole-slide scanning
  • Laser-capture microdissection
  • Histopathology consultation
  • Self-service instrument training
  • Urgent and researcher-tailored services

The main instruments available in this Shared Resource are:

  • Thermo Microtome: HM355S, Finesse, FinesseME and ME+
  • Thermo Fisher Scientific Tissue Processor Shandon Excelsior ES
  • Thermo HistoStar Embedding station
  • Thermo Cryostat # NX50
  • Leica Cryostat CM 3050S
  • Leica Multi Stainer ST5020
  • Leica Glass Coverslipper CV5030
  • Olympus VS200 slide scanner
  • Roche Discovery Ultra Automated IHC/ISH platform
  • Leica Microdissection System LMD7000

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Cold Spring Harbor Laboratory is an NCI-designated Cancer Center. As a basic research institution, CSHL does not treat patients. Information about individual cancers is available at the NCI CancerNet. Questions about CSHL’s cancer research program should be directed to our Communications Department.