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Corina Amor Vegas

Corina Amor Vegas

Assistant Professor
Cancer Center Program Co-Leader

M.D., Ph.D., Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 2021

amor@cshl.edu | 516-367-5504

Amor Vegas Lab Website   Faculty Profile

As we age our body accumulates damaged “senescent” cells that our immune system is no longer able to effectively eliminate. Senescent cells are responsible for the development of aging and age-related diseases like cancer or fibrosis. My group studies how senescent cells evade the immune system thereby identifying new therapeutic approaches.

Our lab studies cellular senescence. Senescence is a stress response program that is triggered in damaged cells and leads to their elimination by the immune system. If uncleared, the accumulation of senescent cells generates a chronic pro-inflammatory microenvironment that conduces to aging and tumor development. We seek to understand how the immune system recognizes and targets these cells in physiological conditions and how senescent cells evade immune clearance in disease. We aim to leverage our findings to develop immune-based therapeutic approaches to target senescent cells in cancer, aging and age-related pathologies. In our studies we develop and combine novel somatic mouse models of cancer and cell-based therapeutics such as our recently developed senolytic CAR T cells.

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All Publications

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

29 Jul 2025 | Proceedings of the National Academy of Sciences of the United States of America | 122(30):e2424286122
Boyer, Jacob;  Rosen, Ezra;  Sharma, Malvika;  Dorso, Madeline;  Mai, Nicholas;  Amor, Corina;  Reiter, Jason;  Kannan, Ram;  Gadal, Sunyana;  Xu, Jianing;  Miele, Matthew;  Li, Zhuoning;  Chen, Xiaoping;  Chang, Qing;  Pareja, Fresia;  Worland, Stephan;  Warner, Douglas;  Sperry, Sam;  Chiang, Gary;  Thompson, Peggy;  Yang, Guangli;  Ouerfelli, Ouathek;  Drilon, Alexander;  de Stanchina, Elisa;  Wendel, Hans-Guido;  Chandarlapaty, Sarat;  Rosen, Neal;  

Aging and immunity: the age-old tango

28 May 2025 | Genes & Development
Fernández Maestre, Inés;  Harris, Alexander;  Amor, Corina;  

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

28 Sep 2024 | Cell Death and Disease | 15(9):694
Murga, Matilde;  Lopez-Pernas, Gema;  Soliva, Robert;  Fueyo-Marcos, Elena;  Amor, Corina;  Faustino, Ignacio;  Serna, Marina;  Serrano, Alicia;  Díaz, Lucía;  Martínez, Sonia;  Blanco-Aparicio, Carmen;  Antón, Marta;  Seashore-Ludlow, Brinton;  Pastor, Joaquín;  Jafari, Rozbeh;  Lafarga, Miguel;  Llorca, Oscar;  Orozco, Modesto;  Fernández-Capetillo, Oscar;  

A brain-body feedback loop driving HPA-axis dysfunction in breast cancer

14 Sep 2024 | bioRxiv
Gomez, Adrian;  Wu, Yue;  Zhang, Chao;  Boyd, Leah;  Wee, Tse-Luen;  Gewolb, Joseph;  Amor, Corina;  Cheadle, Lucas;  Borniger, Jeremy;  

SGLT2 regulates immune-mediated senolysis

10 Jun 2024 | Nature Aging
Guo, Guangran;  Amor, Corina;  

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

11 May 2024 | bioRxiv
Boyer, Jacob;  Sharma, Malvika;  Dorso, Madeline;  Mai, Nicholas;  Amor, Corina;  Reiter, Jason;  Kannan, Ram;  Gadal, Sunyana;  Xu, Jianing;  Miele, Matthew;  Zhuoning, Li;  Chen, Xiaoping;  Chang, Qing;  Pareja, Fresia;  Worland, Stephan;  Warner, Douglas;  Sperry, Sam;  Chiang, Gary;  Thompson, Peggy;  Yang, Guangli;  Ouerfelli, Ouathek;  De Stanchina, Elisa;  Wendel, Hans;  Rosen, Ezra;  Chandarlapaty, Sarat;  Rosen, Neal;  

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

22 Mar 2024 | bioRxiv
Eskiocak, Onur;  Chowdhury, Saria;  Shah, Vyom;  Nnuji-John, Emmanuella;  Chung, Charlie;  Boyer, Jacob;  Harris, Alexander;  Habel, Jill;  Sadelain, Michel;  Beyaz, Semir;  Amor, Corina;  

Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies.

Mar 2024 | Nature | 627(8004):E9
Amor, Corina;  Feucht, Judith;  Leibold, Josef;  Ho, Yu-Jui;  Zhu, Changyu;  Alonso-Curbelo, Direna;  Mansilla-Soto, Jorge;  Boyer, Jacob;  Li, Xiang;  Giavridis, Theodoros;  Kulick, Amanda;  Houlihan, Shauna;  Peerschke, Ellinor;  Friedman, Scott;  Ponomarev, Vladimir;  Piersigilli, Alessandra;  Sadelain, Michel;  Lowe, Scott;  

Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease

18 Mar 2024 | Journal of Hepatology | :S0168-8278(24)00197
Yashaswini, Chittampalli;  Qin, Tianyue;  Bhattacharya, Dipankar;  Amor, Corina;  Lowe, Scott;  Lujambio, Amaia;  Wang, Shuang;  Friedman, Scott;  

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

24 Jan 2024 | Nature Aging
Amor, Corina;  Fernández-Maestre, Inés;  Chowdhury, Saria;  Ho, Yu-Jui;  Nadella, Sandeep;  Graham, Courtenay;  Carrasco, Sebastian;  Nnuji-John, Emmanuella;  Feucht, Judith;  Hinterleitner, Clemens;  Barthet, Valentin;  Boyer, Jacob;  Mezzadra, Riccardo;  Wereski, Matthew;  Tuveson, David;  Levine, Ross;  Jones, Lee;  Sadelain, Michel;  Lowe, Scott;  

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