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CSHL Stories and Media archive for Tag: structural biology

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A molecular machine’s secret weapon exposed

2/23/2023

A shape-shifter with a protruding arm and an appetite for unwanted RNA! CSHL biochemists identify the hidden talents of a mysterious molecule. Read the story »

A new look at brain function and psychiatric disorders

11/2/2022

CSHL scientists’ new 3D models of NMDA brain receptor variants could lead to better treatments for schizophrenia, stroke, depression, and Alzheimer’s. Read the story »

Mapping out new routes to treat brain disorders

6/10/2022

CSHL scientists explore new angles to improve brain disorder therapies with 3D maps of the NMDA receptor, a key player in Alzheimer's and epilepsy. Read the story »

Decoding how a protein on the move keeps cells healthy

5/31/2022

The Argonaute protein is a workhorse for cell regulation and CSHL researchers discovered what helps it commute from job to job. Read the story »

black and white photo of Leemor Joshua-Tor with SBS students

Open access: The pathway to successful collaborations

12/30/2021

2021 marks the 50th anniversary of the Protein Data Bank, a data bank that revolutionized scientific data standardization, transparency, and access. Read the story »

DNA replication: A game of precision

4/25/2021

A highly choreographed complex of molecules is vital to starting and synchronizing DNA replication during cell division. Read the story »

cryo-em image of the Asterix/Gtsf1 protein

How to tame a restless genome

4/8/2021

CSHL researchers found a mechanism to keep otherwise mobile genetic elements in place in the genome. Read the story »

How human cells coordinate the start of DNA replication

3/23/2021

Researchers discover how human cells regulate DNA replication, an important part of cell division, in time and space. Read the story »

Joshua-Tor wins Biophysical Society honor

11/16/2020

CSHL Professor and HHMI Investigator Leemor Joshua-Tor was named a 2021 Fellow of the Biophysical Society for her work on RNAi and DNA replication. Read the story »

still image from ORC dances around DNA video

The “ORC” twists, pinches, and dances around DNA

9/16/2020

The Origin Recognition Complex (ORC) is a key piece of cellular machinery, fundamental to life, yet so far mysterious. Watch the video »

Replicating a genome starts with a twist, a pinch, and a bit of a dance

9/16/2020

Researchers have their first high resolution look at how “ORC,” a human protein complex essential to life, moves. Read the story »

photo of scientists Jessica Tollkuhn Mikala Egeblad and Leemor Joshua-Tor

What do these scientist moms do? Ask their kids.

5/8/2020

We asked the children of three scientists to describe their mother’s work. See what they had to say. Read the story »

Images of ‘invisible’ holes on cells may jumpstart research

3/3/2020

Cellular pores, once impossible to see, have been imaged for the first time. This sets the stage for new discoveries about blood pressure and pain. Read the story »

Cracking the case of the norovirus

2/6/2020

A pervasive virus has evaded vaccine developers for decades. By getting a clear look at its protective shell, they may finally know how to defeat it. Read the story »

3D image of CALHM (calcium homeostasis modulators) pore

New look at odd holes involved in taste, Alzheimer’s, asthma

1/27/2020

Large holes in our cells have been implicated in depression, Alzehimer’s disease, asthma, and even taste. Now, we know what two of these pores look like. Read the story »

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