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CSHL Stories and Media archive for Tag: structural biology

A recipe to reverse cancer’s sweet tooth

6/16/2025

Researchers reveal the first 3D structures of the kinase FN3K in different states, which may inform future therapeutics for a variety of cancers. Read the story »

At the Lab: The human Microprocessor

5/27/2025

There’s a Microprocessor inside you. Actually, there are trillions. Only they’re not computer processors. They’re much smaller and far more complex. Listen to the podcast »

Ketamine: From club drug to antidepressant?

2/14/2025

CSHL Professor Hiro Furukawa proves the existence of a mysterious brain receptor known as GluN1-2B-2D and shows how it may interact with ketamine. Read the story »

Eyes on the atom

12/31/2024

Zoom in on the Nobel Prize-winning technology students in CSHL’s Cryo-EM Course use to study the structure and function of cells. Watch the video »

The Microprocessor inside you

12/2/2024

Stunning new images from CSHL’s Joshua-Tor lab reveal how the protein complex interacts with differently shaped primary microRNAs. Read the story »

image of Anti-NMDAR encephalitis antibodies

Putting out a brain on fire

10/17/2024

CSHL Professor Hiro Furukawa sheds new light on anti-NMDAR encephalitis, a rare autoimmune disorder that may be misdiagnosed as schizophrenia. Read the story »

This protein does “The Twist”

7/31/2024

CSHL Professor Hiro Furukawa has figured out how the NMDAR performs a key step in the brain’s cognitive dance. Read the story »

image of Leemor Joshua-Tor with Cold Spring Harbor waterfront in the background

Dream big: A powerful vision for CSHL research

1/2/2024

New Cold Spring Harbor Laboratory Director of Research Leemor Joshua-Tor shares her vision for the future of bioscience discovery. Read the story »

image of the video slide for Dance of epigenetic inheritance

The dance of epigenetic inheritance

9/27/2023

Making sure chromosomes get passed down correctly is hard work. Watch, through fluorescent and cryogenic lenses, how two proteins make it happen. Watch the video »

How plants pass down genetic memories

8/28/2023

Thirty years ago, CSHL’s Rob Martienssen discovered plant gene DDM1. Now, he’s identified just how the DDM1 protein helps control inheritance. Read the story »

Cryo-electron microscopy image of a human CALHM1 channel

This eight-armed octopus-like pore perceives taste

7/14/2023

CSHL captures never-before-seen images of the human CALHM1 channel, a mysterious cellular passageway that may be connected to Alzheimer’s disease. Read the story »

A molecular machine’s secret weapon exposed

2/23/2023

A shape-shifter with a protruding arm and an appetite for unwanted RNA! CSHL biochemists identify the hidden talents of a mysterious molecule. Read the story »

A new look at brain function and psychiatric disorders

11/2/2022

CSHL scientists’ new 3D models of NMDA brain receptor variants could lead to better treatments for schizophrenia, stroke, depression, and Alzheimer’s. Read the story »

Mapping out new routes to treat brain disorders

6/10/2022

CSHL scientists explore new angles to improve brain disorder therapies with 3D maps of the NMDA receptor, a key player in Alzheimer's and epilepsy. Read the story »

Decoding how a protein on the move keeps cells healthy

5/31/2022

The Argonaute protein is a workhorse for cell regulation and CSHL researchers discovered what helps it commute from job to job. Read the story »

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