How key brain receptor works in hostile conditions May 9, 2018 A structural variation enables a key brain receptor to function in a hostile environment
Detailed images of NMDA receptor show how zinc and a potential drug affect its function December 1, 2016 Drugs precisely targeting portions of the NMDA receptor may have applications in Alzheimer’s, depression and schizophrenia.
Unprecedented detail of intact neuronal receptor offers blueprint for drug developers May 29, 2014 NMDA receptor malfunction is implicated in Alzheimer’s, Parkinson’s, depression, schizophrenia, autism, and stroke
Israel and Lavine select CSHL to announce initiative to make NY center of Alzheimer’s research June 20, 2013 Congressman Israel and Assemblyman Lavine select Cold Spring Harbor Laboratory to announce initiative to make NY the center of Alzheimer's research
One experiment: Capturing a drug in its binding pocket June 1, 2013 Erkan Karakas, a post-doc in Hiro Furukawa's lab, finds an elusive binding pocket that could help in the treatment of neurodegenerative diseases.
Scientists reverse Alzheimer’s-like memory loss in animal models by blocking EGFR signaling September 24, 2012 EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss
Storm of ‘awakened’ transposons may cause brain-cell pathologies in ALS, other illnesses September 4, 2012 A team of neuroscientists and informatics experts at CSHL reports important progress today in an effort to understand the relationship between transpo
Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding December 13, 2011 Hydrogen sulfide plays an important role in the regulation of a signaling pathway implicated in biological malfunctions linked to Alzheimer’s.
Alzheimer’s disease: A CSHL study cited as a key advance May 4, 2011 CSHL's Yi Zhong explores a specific peptide in the brain, which could be a viable target for therapeutic intervention for alzheimer's disease.
CSHL scientists identify elusive neuronal targets of deep brain stimulation December 15, 2010 Study might provide new clues to designing better treatments for depression and other neuropsychiatric disorders
One experiment: Watching deep brain stimulation spur neuronal birth December 15, 2010 CSHL's Grigori Enikolopov examines how deep brain stimulation effects the hippocampus and how it connect to neurological diseases.
CSHL neuroscientists reverse Alzheimer’s-like memory loss by targeting signaling protein in fruitflies March 29, 2010 B-amyloid peptides are known to alter a slew of cellular signaling proteins such as PI3 kinase.
CSHL team solves molecular structure of NMDA receptor subunit that could be target for drugs against neurological diseases November 13, 2009 A domain of the NR2B subunit of the NMDA receptor is mapped in exquisite detail.
Scientists demonstrate means of reducing Alzheimer’s-like plaques in fly brain July 14, 2008 But overexpression of Neprilysin causes other serious pathologies.
Neuroscientists show insulin receptor signaling regulates structure and function of brain circuits June 18, 2008 Impact of the signaling upon synapses and dendrites is shown for the first time in living creatures
