Brain receptor pulls open electrical gate like a puppet master 6/30/2020 When stimulated by a neurotransmitter or drug, the NMDA receptor pulls open an ion gate that allows ions to flow. Read the story »
New look at odd holes involved in taste, Alzheimer’s, asthma 1/27/2020 Large holes in our cells have been implicated in depression, Alzehimer’s disease, asthma, and even taste. Now, we know what two of these pores look like. Read the story »
New tool for investigating brain cells, Parkinson’s, & more 1/22/2020 Researchers have created a new chemical tool for revealing how specific types of brain cell receptors function in the brain. Watch the video »
New tool for investigating brain cells, Parkinson’s, & more 1/22/2020 Researchers have crafted a compound for targeting specific brain cell receptors, creating new opportunities to study the brain and Parkinson’s disease. Read the story »
The non-human living inside of you 1/9/2020 A large part of human DNA doesn’t aid the normal workings of the body. This “junk DNA” contains ancient viruses that may spur diseases like ALS. Read the story »
How key brain receptor works in hostile conditions 5/9/2018 A structural variation enables a key brain receptor to function in a hostile environment Read the story »
Detailed images of NMDA receptor show how zinc and a potential drug affect its function 12/1/2016 Drugs precisely targeting portions of the NMDA receptor may have applications in Alzheimer’s, depression and schizophrenia. Read the story »
Unprecedented detail of intact neuronal receptor offers blueprint for drug developers 5/29/2014 NMDA receptor malfunction is implicated in Alzheimer’s, Parkinson’s, depression, schizophrenia, autism, and stroke Read the story »
Israel and Lavine select CSHL to announce initiative to make NY center of Alzheimer’s research 6/20/2013 Congressman Israel and Assemblyman Lavine select Cold Spring Harbor Laboratory to announce initiative to make NY the center of Alzheimer's research Read the story »
One experiment: Capturing a drug in its binding pocket 6/1/2013 Erkan Karakas, a post-doc in Hiro Furukawa's lab, finds an elusive binding pocket that could help in the treatment of neurodegenerative diseases. Read the story »
Scientists reverse Alzheimer’s-like memory loss in animal models by blocking EGFR signaling 9/24/2012 EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss Read the story »
Storm of ‘awakened’ transposons may cause brain-cell pathologies in ALS, other illnesses 9/4/2012 A team of neuroscientists and informatics experts at CSHL reports important progress today in an effort to understand the relationship between transpo Read the story »
Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding 12/13/2011 Hydrogen sulfide plays an important role in the regulation of a signaling pathway implicated in biological malfunctions linked to Alzheimer’s. Read the story »
Alzheimer’s disease: A CSHL study cited as a key advance 5/4/2011 CSHL's Yi Zhong explores a specific peptide in the brain, which could be a viable target for therapeutic intervention for alzheimer's disease. Read the story »
CSHL scientists identify elusive neuronal targets of deep brain stimulation 12/15/2010 Study might provide new clues to designing better treatments for depression and other neuropsychiatric disorders Read the story »