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CSHL Story and Media archive for Tag: alzheimers

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How key brain receptor works in hostile conditions

5/9/2018

A structural variation enables a key brain receptor to function in a hostile environment Read the story »

Detailed images of NMDA receptor show how zinc and a potential drug affect its function

12/1/2016

Drugs precisely targeting portions of the NMDA receptor may have applications in Alzheimer’s, depression and schizophrenia. Read the story »

GluN1a/GluN2B NMDA receptors calcium-binding

Unprecedented detail of intact neuronal receptor offers blueprint for drug developers

5/29/2014

NMDA receptor malfunction is implicated in Alzheimer’s, Parkinson’s, depression, schizophrenia, autism, and stroke Read the story »

Israel and Lavine select CSHL to announce initiative to make NY center of Alzheimer’s research

6/20/2013

Congressman Israel and Assemblyman Lavine select Cold Spring Harbor Laboratory to announce initiative to make NY the center of Alzheimer's research Read the story »

One experiment: Capturing a drug in its binding pocket

6/1/2013

Erkan Karakas, a post-doc in Hiro Furukawa's lab, finds an elusive binding pocket that could help in the treatment of neurodegenerative diseases. Read the story »

Scientists reverse Alzheimer’s-like memory loss in animal models by blocking EGFR signaling

9/24/2012

EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss Read the story »

Storm of ‘awakened’ transposons may cause brain-cell pathologies in ALS, other illnesses

9/4/2012

A team of neuroscientists and informatics experts at CSHL reports important progress today in an effort to understand the relationship between transpo Read the story »

Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding

12/13/2011

Hydrogen sulfide plays an important role in the regulation of a signaling pathway implicated in biological malfunctions linked to Alzheimer’s. Read the story »

Alzheimer’s disease: A CSHL study cited as a key advance

5/4/2011

CSHL's Yi Zhong explores a specific peptide in the brain, which could be a viable target for therapeutic intervention for alzheimer's disease. Read the story »

CSHL scientists identify elusive neuronal targets of deep brain stimulation

12/15/2010

Study might provide new clues to designing better treatments for depression and other neuropsychiatric disorders Read the story »

One experiment: Watching deep brain stimulation spur neuronal birth

12/15/2010

CSHL's Grigori Enikolopov examines how deep brain stimulation effects the hippocampus and how it connect to neurological diseases. Read the story »

CSHL neuroscientists reverse Alzheimer’s-like memory loss by targeting signaling protein in fruitflies

3/29/2010

B-amyloid peptides are known to alter a slew of cellular signaling proteins such as PI3 kinase. Read the story »

CSHL team solves molecular structure of NMDA receptor subunit that could be target for drugs against neurological diseases

11/13/2009

A domain of the NR2B subunit of the NMDA receptor is mapped in exquisite detail. Read the story »

NEP NEPmut Axonal dendritic localization

Scientists demonstrate means of reducing Alzheimer’s-like plaques in fly brain

7/14/2008

But overexpression of Neprilysin causes other serious pathologies. Read the story »

Electron micrographs ultrastructural morphology

Neuroscientists show insulin receptor signaling regulates structure and function of brain circuits

6/18/2008

Impact of the signaling upon synapses and dendrites is shown for the first time in living creatures Read the story »