Knowing what to keep and what to trash: How an enzyme distinguishes cellular messages 8/3/2014 Molecular structure reveals how a protein reads RNAs to preserve stem cell identity Read the story »
Biologists characterize enzymatic identity of key player in generating genome-protecting piRNAs 10/11/2012 Scientists work to understand the earliest steps in a process that protects animal genomes from potentially dangerous genetic elements Read the story »
CSHL team solves a protein complex’s molecular structure to explain its role in gene silencing 11/14/2011 Researchers discover new details of how the RNA-Induced Initiation of Transcriptional gene Silencing (RITS) complex contributes to gene silencing Read the story »
CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit 6/16/2011 Researchers create detailed blueprint of the allosteric site where phenylethanolamines bind to the receptor for future neurological treatments Read the story »
CSHL structural biologists reveal molecular architecture of key NMDA receptor subunit 4/26/2011 Structure of GluN2D subunit when docked with certain neurotransmitters helps explain the receptor's slow deactivation. Read the story »
CSHL researchers explain process by which cells “hide” potentially dangerous DNA segments 4/9/2009 Chp1, a histone-binding protein, helps recruit molecular machinery that establishes heterochromatin “silencing” domains Read the story »
Scientists at Cold Spring Harbor Laboratory discover new details of a gene-regulatory network governing metabolism 2/22/2008 Researchers discover how yeast cells, through the action of genes, adjust their metabolism in response to changes in their sources of food. Read the story »
Structural basis of malaria infection 7/28/2005 Researchers determine the molecular structure of a protein that enables malaria parasites to invade red blood cells. Read the story »
The beak of the squid*: Researchers reveal Argonaute2 protein as the catalytic engine of mammalian RNA interference 7/28/2004 Two studies find that Argonaute2 is the element responsible for the cutting action that carries out RNAi-mediated messenger RNA cleavage. Read the story »
