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Targeting ‘hidden pocket’ for treatment of stroke and seizure

January 18, 2019

Researchers have identified a hidden molecular “pocket” in a special neuron receptor, which could lead to better treatments for stroke and seizures.

Portrait of a Neuroscience Powerhouse

April 27, 2018

A relatively small neuroscience group at CSHL is having an outsized impact on a dynamic and highly competitive field

45 years later, a scientist realizes he’s a star

January 24, 2018

David Haas was stunned to learn the impact of work he abandoned decades ago. He took a CSHL course to see it for himself.

Research profile: Leemor Joshua-Tor

November 27, 2017

A CSHL faculty member since 1995, a professor since 2005, Joshua-Tor is among the most distinguished members of the Laboratory community.

Freeze-frames of enzymes in action have implications for a new cancer treatment concept

July 3, 2017

TUTase enzymes interact with let-7, a regulator of development; targeting them could help control certain cancers.

CSHL’s Dr. Leemor Joshua-Tor is elected to The National Academy of Sciences

May 2, 2017

Professor Leemor Joshua-Tor has been elected to The National Academy of Sciences (NAS).

Protein complex that takes first steps in human DNA replication dance is captured at high atomic resolution

March 16, 2017

Human ORC complex captured in action in x-ray crystallography and cryo-EM

New art supplies for visualizing tiny machines in the brain

March 1, 2017

An unusual, but beautiful sight can be found among the figures of a recent scientific paper about some of the tiny machines in our brain: watercolor

Detailed images of NMDA receptor show how zinc and a potential drug affect its function

December 1, 2016

Drugs precisely targeting portions of the NMDA receptor may have applications in Alzheimer’s, depression and schizophrenia.

In a role reversal, RNAs proofread themselves

January 29, 2015

Molecular photographs of an enzyme bound to RNA reveal a new, inherent quality control mechanism

RNA and U with fifth-year student Jack Walleshauser

December 10, 2014

Jack Walleshauser wins the student poster prize at the 2014 in-house symposium.

Knowing what to keep and what to trash: How an enzyme distinguishes cellular messages

August 3, 2014

Molecular structure reveals how a protein reads RNAs to preserve stem cell identity

Biologists characterize enzymatic identity of key player in generating genome-protecting piRNAs

October 11, 2012

Scientists work to understand the earliest steps in a process that protects animal genomes from potentially dangerous genetic elements

CSHL team solves a protein complex’s molecular structure to explain its role in gene silencing

November 14, 2011

Researchers discover new details of how the RNA-Induced Initiation of Transcriptional gene Silencing (RITS) complex contributes to gene silencing

CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit

June 16, 2011

Researchers create detailed blueprint of the allosteric site where phenylethanolamines bind to the receptor for future neurological treatments

CSHL Story archive for Tag: x-ray crystallography