On October 19, 2022, members of Manhasset Women’s Coalition Against Breast Cancer (MWCABC) presented a $75,000 check to Cold Spring Harbor Laboratory’s (CSHL) Dr. Corina Amor to support her research project – Harnessing Senolytic CAR T Cells for The Treatment of Breast Cancer. Since 1999, CSHL has received nearly $650,000 in funding for breast cancer research from MWCABC.
Dr. Amor, who came to CSHL in early 2022 from Memorial Sloan Kettering Cancer Center, is studying cellular senescence, a stress response program that is triggered in damaged cells and leads to their elimination by the immune system. If uncleared, the accumulation of senescent cells generates a chronic pro-inflammatory microenvironment that conduces to aging and tumor development. Her lab seeks to understand how the immune system recognizes and targets these cells in physiological conditions and how senescent cells evade immune clearance in disease. They ultimately hope to utilize their findings to develop immune-based therapeutic approaches to target senescent cells in cancer, aging and age-related pathologies.
MWCABC is an all-volunteer, charitable organization whose mission is to find a cure for breast cancer. They hold various fundraising events throughout the year including an annual “Ladies Night Out.” CSHL is grateful for MWCABC’s generous support of Dr. Amor and other researchers in the past.