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CSHL Stories and Media archive for Tag: Adrian Krainer

Study reveals details of alternative splicing circuitry that promotes cancer’s Warburg effect

11/2/2011

Dr. Krainer and his team discovered details of the molecular events that trigger the production of the enzyme that drives the Warburg effect. Read the story »

Antisense therapy delivers long-term correction of severe spinal muscular atrophy in mice

10/5/2011

Researchers report surprising results that suggest that spinal muscular atrophy might not exclusively affect the motor neurons in the spinal cord. Read the story »

Collaboration column: SMA therapeutics and potential drug target for schizophrenia

3/11/2011

CSHL's Adrian Krainer works on treatment for spinal muscular atrophy that reverses the disease's symptoms. Read the story »

CSHL researchers demonstrate efficacy of antisense therapy for spinal muscular atrophy

7/12/2010

Researchers look into the use of chemically-modified pieces of RNA called antisense oligonucleotides to treat SMA. Read the story »

expression patterns of pyruvate kinase M1/M2 isoforms

CSHL study identifies potential way to reverse cancer cell metabolism and tumor growth

1/22/2010

Altered metabolism in cancer cells is most critically mediated by a protein called PK-M2. Read the story »

Researchers identify drug candidate for treating spinal muscular atrophy

11/4/2009

A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA) Read the story »

CSHL scientists clarify “editing error” underlying a devastating genetic neurodegenerative disease

1/28/2009

Research uncovers new details about how a gene mutation causes a cellular editing error resulting in pontocerebellar hypoplasia (PCH). Read the story »

Cold Spring Harbor Laboratory scientists trace a novel way cells are modified in cancer

10/2/2008

A splicing factor targets known cancer-related proteins. Read the story »

CSHL team traces extensive regulatory networks that help determine how certain RNA messages are alternatively “spliced”

9/19/2008

Fox-1 and Fox-2 are tissue-specific splicing factors; their RNA targets in the genome are successfully predicted. Read the story »

Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy

4/4/2008

CSHL and Ionis Pharmaceuticals have induced cells to replenish the protein by activating an existing, slightly modified copy of the mutant gene. Read the story »

CSHL shows correcting RNA splicing may help treat spinal muscular atrophy

3/12/2007

PLoS Biology publishes "Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon" Read the story »

CSHL researchers show RNA splicing factor may be new target for cancer therapy

2/8/2007

Nature Structural & Molecular Biology publishes “The gene encoding the splicing factor SF2/ASF is a proto-oncogene” Read the story »

SMA Foundation brings experienced researcher to Cold Spring Harbor Laboratory

7/30/2004

Funding from the Spinal Muscular Atrophy Foundation has brought Dr. Yimin Hua to Cold Spring Harbor Laboratory Read the story »

Designer molecules correct RNA splicing defects

1/12/2003

Adrian Krainer and his team have discovered a new method to correct RNA splicing defects that may cause diseases. Read the story »

RNA splicing study aids understanding of breast cancer, cystic fibrosis and other diseases

4/16/2001

Researchers discover the mechanism of NAS and other related RNA splicing defects. Read the story »

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