New book on Cell Survival and Cell Death from CSHLPress

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Cold Spring Harbor, NY — Cold Spring Harbor Laboratory Press (CSHLP) announced the release of Cell Survival and Cell Death, 2e, available on its website in hardcover and eBook formats.

life and death symbolized by the winged hourglass
Our intimate connection with life and death is symbolized by the winged hourglass, reminding each of us how time flies swiftly from light into darkness. An instrument so revealing in its duality, the scythe both ends and renews life’s circle. Face masks worn by plague doctors during epidemics connect cell death to pathogen defense with living and apoptotic cells at the heart of each practitioner.

In multicellular organisms, cell death is required for normal development, homeostasis, and the elimination of infected or injured cells. The mechanisms by which cell death occurs are genetically encoded and carefully controlled. Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases.

Written and edited by experts in the field, Cell Survival and Cell Death, 2e from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor-ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP. They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components.

Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs.


Please visit our website at cshlpress.org to access free sample material and for further information on this title.

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Robert Redmond