Researchers Report Complete Rice Genome Sequence
Rice feeds more than half of the world’s human population. Estimates indicate that the agricultural yield of rice will need to be increased by some 30% over the next two decades to meet projected increased demands. In the August 11 issue of the journal Nature, members of a 10-nation International Rice Genome Sequencing Project (IRGSP) report a highly accurate or “finished” map-based DNA sequence of the entire rice genome. The completed rice genome sequence, which reveals some 37,500 genes on the 12 chromosomes of rice, provides the raw material for many studies aimed at improving the agricultural yield of the world’s most important food source.
Moreover, because the rice genome is closely related to that of other major cereal grasses—including corn, wheat, barley, rye, sorghum, and millet—the complete rice genome sequence is an extraordinarily useful resource for identifying genes of interest in a number of different crop plants that collectively supply two-thirds of humanity’s food supply.
“This study revealed thousands of genetic markers or signposts in the rice genome that are of immediate use to plant breeders and others working to improve rice agriculture,” says Dr. W. Richard McCombie of Cold Spring Harbor Laboratory, a co-leader of the study.
“This is also the first finished genome sequence we have from any crop plant, so rice is now a great model for how to use genome sequence information to improve many other aspects of agriculture,” says McCombie, who adds that several programs are already underway to study the structure and function of rice genes as well as agriculturally relevant genetic variation among different varieties of rice.
By enabling scientists to identify genes that underlie agriculturally important traits, a previous IRGSP-generated rough draft of the rice genome sequence—made publicly available in 2002—has already spurred both biotechnological and conventional plant breeding approaches to increase rice yields. The newly-reported, finished rice genome sequence has the potential to greatly accelerate these efforts.
Formally established in 1998, the Japanese-led International Rice Genome Sequencing Project comprises researchers from 32 institutions in Japan, China, India, Thailand, Taiwan, Brazil, France, Canada, the United Kingdom, and the United States. Major U.S. funding for the project was from the National Science Foundation, U.S. Department of Agriculture-Cooperative State Research, Education and Extension Service, U.S. Department of Energy, and the Rockefeller Foundation. U.S. Efforts were coordinated by the National Plant Genome Initiative.
Participating U.S. institutions were Cold Spring Harbor Laboratory, the University of Arizona, Rutgers University, The Institute for Genomic Research, Washington University in St. Louis, the University of Wisconsin-Madison, Brookhaven National Laboratory, and Cornell University.
Founded in 1890, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. Home to eight Nobel Prize winners, the private, not-for-profit Laboratory employs 1,100 people including 600 scientists, students and technicians. The Meetings & Courses Program annually hosts more than 12,000 scientists. The Laboratory’s education arm also includes an academic publishing house, a graduate school and the DNA Learning Center with programs for middle and high school students and teachers. For more information, visit www.cshl.edu