Research Archives - Cold Spring Harbor Laboratory

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An essay from the President: Biology for the planet

May 16, 2019

CSHL plant scientists are looking for solutions to the biggest questions in agriculture as environments are reshaped by climate change.

Enzyme PHLPP2 could be a viable drug target for treating prostate cancer

May 15, 2019

Researchers have identified an enzyme called Phlpp2 as an attractive drug target for treating prostate cancer.

Profile: Doreen Ware champions the plant genome

May 8, 2019

Molecular biologist Doreen Ware uses computer science to parse out the genetic roadmaps of plants.

Cryptic mutation is cautionary tale for crop gene editing

May 6, 2019

Unexpected interactions between mutations can be a thorn in the side for plant breeders. Scientists unveil what drove one infamous “cryptic” mutation.

Andrea Schorn zooms in on small RNAs in the cell

April 29, 2019

Dr. Andrea Schorn joins CSHL faculty as research assistant professor. Her focus is exploring transposable elements in the genome of mammalian cells.

Cold Spring Harbor Laboratory announces exclusive license with plant breeding start-up Inari

April 16, 2019

CSHL announced a licensing agreement with partner Inari, a company that is advancing plant breeding by tapping nature’s genetic diversity.

To protect stem cells, plants have diverse genetic backup plans

April 15, 2019

Experts discover how an essential genetic circuit found in all flowering plants, regardless of species, is protected in startlingly different ways.

Crop yield in maize influenced by unexpected gene ‘moonlighting’

April 1, 2019

Yield of the maize plant is tied to activity of a gene called RAMOSA3, but new evidence suggests the gene performs other unexpected functions

One experiment: Observing cancer’s progress in a mouse prostate

March 14, 2019

Using a technique originally designed for mapping brains, two CSHL labs have worked together to image cancer progression in a mouse prostate.

New cell subtypes classified in mouse brain

March 12, 2019

To map a brain, an intuitive system for classifying neuron types is necessary. Now, a promising approach reveals new cell subtypes in the mouse brain.

Genetic ‘usual suspects’ identified in researchers’ new list

March 4, 2019

An exhaustive ranked list of “usual suspect” genes involved in disease may prove invaluable for future research and drug discovery.

Chandelier neuron requires ‘Velcro-like’ molecule to form connections

March 4, 2019

How do brain cells network? Researchers have discovered an essential ingredient that facilitates one type of neuron’s many neighborly connections.

Detailed new primate brain atlas could lead to disease insights

March 1, 2019

An international effort has mapped the marmoset brain at an unprecedented level of detail, which brings us closer to understanding the human brain.

How does math help us understand the brain?

January 31, 2019

An exploration of how computational neuroscientist Tatiana Engel uses math to understand how the brain makes decisions.

Targeting ‘hidden pocket’ for treatment of stroke and seizure

January 18, 2019

Researchers have identified a hidden molecular “pocket” in a special neuron receptor, which could lead to better treatments for stroke and seizures.