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Relationship between incorrect chromosome number and cancer is reassessed

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number. Today in the journal Cancer Cell, Cold Spring Harbor Laboratory (CSHL) Fellow Jason Sheltzer, Ph.D., and colleagues at CSHL and MIT report surprising results of experiments intended to explore the consequences of having too many or too few chromosomes, a phenomenon that biologists call aneuploidy (AN-you-ploid-ee).