CSHL Menu
Molly Gale Hammell

Molly Gale Hammell

Associate Professor
Cancer Center Member

Ph.D., Dartmouth College, 2003

mhammell@cshl.edu | 516-367-5009

Gale Hammell Lab Website   Faculty Profile

To ensure that cells function normally, tens of thousands of genes must be turned on or off together. To do this, regulatory molecules—transcription factors and non-coding RNAs—simultaneously control hundreds of genes. My group studies how the resulting gene networks function and how they can be compromised in aging associated diseases, such as neurodegeneration and cancer.

Human development requires the regulated activity of thousands of genes in hundreds of distinct cell types throughout life. One requirement for this process is that each cell must contain an intact, functional genome free from mutations. One type of mutation can arise from the activation of transposable elements (TEs). These viral-like parasites lay dormant within our genomes, but have the capacity to hop into new genomic locations, causing mutations as they break the surrounding DNA sequence. Mounting evidence has implicated transposon activity in a host of human diseases, with particular evidence for TE activation in neurodegenerative diseases, such as Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD), and cancer.

See all Gale Hammell news

All Publications

Cell environment shapes TDP-43 function with implications in neuronal and muscle disease

5 Apr 2022 | Communications Biology | 5(1):314
Šušnjar, Urša, Škrabar, Neva, Brown, Anna-Leigh, Abbassi, Yasmine, Phatnani, Hemali, NYGC ALS Consortium, Cortese, Andrea, Cereda, Cristina, Bugiardini, Enrico, Cardani, Rosanna, Meola, Giovanni, Ripolone, Michela, Moggio, Maurizio, Romano, Maurizio, Secrier, Maria, Fratta, Pietro, Buratti, Emanuele

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

23 Feb 2022 | Nature | 603(7899):131-137
Brown, Anna-Leigh, Wilkins, Oscar, Keuss, Matthew, Hill, Sarah, Zanovello, Matteo, Lee, Weaverly, Bampton, Alexander, Lee, Flora, Masino, Laura, Qi, Yue, Bryce-Smith, Sam, Gatt, Ariana, Hallegger, Martina, Fagegaltier, Delphine, Phatnani, Hemali, NYGC ALS Consortium, Newcombe, Jia, Gustavsson, Emil, Seddighi, Sahba, Reyes, Joel, Coon, Steven, Ramos, Daniel, Schiavo, Giampietro, Fisher, Elizabeth, Raj, Towfique, Secrier, Maria, Lashley, Tammaryn, Ule, Jernej, Buratti, Emanuele, Humphrey, Jack, Ward, Michael, Fratta, Pietro

NOS1AP is a novel molecular target and critical factor in TDP-43 pathology

1 Jan 2022 | Brain Communications | 4(5)
Cappelli, S, Spalloni, A, Feiguin, F, Visani, G, Šušnjar, U, Brown, A, De Bardi, M, Borsellino, G, Secrier, M, Phatnani, H, Romano, M, Fratta, P, Longone, P, Buratti, E, Phatnani, H, Kwan, J, Sareen, D, Broach, J, Simmons, Z, Arcila-Londono, X, Lee, E, Van Deerlin, V, Shneider, N, Fraenkel, E, Ostrow, L, Baas, F, Zaitlen, N, Berry, J, Malaspina, A, Fratta, P, Cox, G, Thompson, L, Finkbeiner, S, Dardiotis, E, Miller, T, Chandran, S, Pal, S, Hornstein, E, MacGowan, D, Heiman-Patterson, T, Hammell, M, Patsopoulos, N, Butovsky, O, Dubnau, J, Nath, A, Bowser, R, Harms, M, Aronica, E, Poss, M, Phillips-Cremins, J, Crary, J, Atassi, N, Lange, D, Adams, D, Stefanis, L, Gotkine, M, Baloh, R, Babu, S, Raj, T, Paganoni, S, Shalem, O, Smith, C, Zhang, B, Harris, B, Broce, I, Drory, V, Ravits, J, McMillan, C, Menon, V

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

19 Nov 2021 | iScience | 24(11):103221
Phatnani, H, Kwan, J, Sareen, D, Broach, J, Simmons, Z, Arcila-Londono, X, Lee, E, Van Deerlin, V, Shneider, N, Fraenkel, E, Ostrow, L, Baas, F, Zaitlen, N, Berry, J, Malaspina, A, Fratta, P, Cox, G, Thompson, L, Finkbeiner, S, Dardiotis, E, Miller, T, Chandran, S, Pal, S, Hornstein, E, MacGowan, D, Heiman-Patterson, T, Hammell, M, Patsopoulos, N, Butovsky, O, Dubnau, J, Nath, A, Bowser, R, Harms, M, Poss, M, Phillips-Cremins, J, Crary, J, Atassi, N, Lange, D, Adams, D, Stefanis, L, Gotkine, M, Baloh, R, Babu, S, Raj, T, Paganoni, S, Shalem, O, Smith, C, Zhang, B, Harris, B, Broce, I, Drory, V, Ravits, J, McMillan, C, Menon, V, Wu, L, Altschuler, S, Li, J, Lim, R, Kaye, J, Dardov, V, Coyne, A, Wu, J, Milani, P, Cheng, A, Thompson, T, Ornelas, L, Frank, A, Adam, M, Banuelos, M, Casale, M, Cox, V, Escalante-Chong, R, Daigle, J, Gomez, E, Hayes, L, Holewenski, R, Lei, S, Lenail, A, Lima, L, Mandefro, B, Matlock, A, Panther, L, Patel-Murray, N, Pham, J, Ramamoorthy, D, Sachs, K, Shelley, B, Stocksdale, J, Trost, H, Wilhelm, M, Venkatraman, V, Wassie, B, Wyman, S, Yang, S, Van Eyk, J, Lloyd, T, Finkbeiner, S, Rothstein, J, Svendsen, C

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

3 Feb 2021 | Neuron | 109(3):448-460.e4
Dewan, R, Chia, R, Ding, J, Hickman, R, Stein, T, Abramzon, Y, Ahmed, S, Sabir, M, Portley, M, Tucci, A, Ibáñez, K, Shankaracharya, F, Keagle, P, Rossi, G, Caroppo, P, Tagliavini, F, Waldo, M, Johansson, P, Nilsson, C, Adeleye, A, Alba, C, Bacikova, D, Hupalo, D, Martinez, E, Pollard, H, Sukumar, G, Soltis, A, Tuck, M, Zhang, X, Wilkerson, M, Smith, B, Ticozzi, N, Fallini, C, Gkazi, A, Topp, S, Kost, J, Scotter, E, Kenna, K, Miller, J, Tiloca, C, Vance, C, Danielson, E, Troakes, C, Colombrita, C, Al-Sarraj, S, Lewis, E, King, A, Calini, D, Pensato, V, Castellotti, B, de Belleroche, J, Baas, F, ten Asbroek, A, Sapp, P, McKenna-Yasek, D, McLaughlin, R, Polak, M, Asress, S, Esteban-Pérez, J, Muñoz-Blanco, J, Stevic, Z, D'Alfonso, S, Mazzini, L, Comi, G, Del Bo, R, Ceroni, M, Gagliardi, S, Querin, G, Bertolin, C, van Rheenen, W, Diekstra, F, Rademakers, R, van Blitterswijk, M, Boylan, K, Lauria, G, Duga, S, Corti, S, Cereda, C, Corrado, L, Sorarù, G, Williams, K, Nicholson, G, Blair, I, Leblond-Manry, C, Rouleau, G, Hardiman, O, Morrison, K, Veldink, J, van den Berg, L, Al-Chalabi, A, Pall, H, Shaw, P, Turner, M, Talbot, K, Taroni, F, García-Redondo, A, Wu, Z, Gellera, C, Ratti, A, Brown, R

Editorial Overview: Endogenous Retroviruses in Development and Disease

16 Dec 2020 | Viruses | 12(12)
Gale Hammell, M, Rowe, H

Ten Simple Rules for Running a Successful women-in-STEM Organization on an Academic Campus

7 May 2020 | PLoS Computational Biology | 16(5):e1007754
Rupert, D, Nowlan, A, Tam, O, Hammell, M

Mobile Genomics: Tools and Techniques for Tackling Transposons

30 Mar 2020 | Philosophical Transactions of the Royal Society B: Biological Sciences | 375(1795)
O'Neill, K, Brocks, D, Hammell, M

Methods for Running a Successful Women-in-STEM Organization on an Academic Campus

23 Feb 2020 | bioRxiv
Rupert, Deborah, Nowlan, Alexandra, Tam, Oliver, Hammell, Molly

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

29 Oct 2019 | Cell Reports | 29(5):1164-1177.e5
Tam, O, Rozhkov, N, Shaw, R, Kim, D, Hubbard, I, Fennessey, S, Propp, N, Fagegaltier, D, Harris, B, Ostrow, L, Phatnani, H, Ravits, J, Dubnau, J, Gale Hammell, M

See more publications