let's say The SMN Gene generates RNA
copies made up of introns and exons like
this normal RNA splicing would delete
the introns the gibberish letters in
blue and leave only the exons the red
letters generating the following message
draw a big house on the corner of the
wide
Street in SMA it turns out that during
RNA splicing the seventh Exxon of smn2
is skipped by the Machinery that edits
RNA skipping of xon 7 generates a faulty
message draw a big house on the of the
wide
Street just like removing word number
seven in the sentence leads to a
statement that makes no sense removing
exon7 in the RNA results in a defective
protein remember that SMA patients have
to rely solely on the sn2 gene to
produce the survival of motor neuron
protein but due to Exon skipping not
enough usable protein is made to support
normal muscle development