Cold Spring Harbor Laboratory  
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NeuroscienceCSHL neuroscientists focus on understanding how neural connections in the brain translate into behavior. Their research provides insights into the circuitry underlying complex cognitive processes such as decision-making and attention, as well as developing tools to map circuit disruptions associated with neurological disorders, like Alzheimer's disease, autism, schizophrenia and depression.
Neuroscience research at CSHL is centered on three broad themes: sensory processing, cognition, and mental disorders. Sensory processing research explores how sensory experiences, like sound, smell, and sight, are integrated with decision-making. The cognition group uses the tools of modern neuroscience (genetic, molecular, physiology and imaging) to study the neural circuitry that underlies attention, memory, and decision-making. Researchers also study cognitive disorders, defining the genetic basis of diseases like autism and schizophrenia and identifying the neural circuits that are disrupted in these disorders. In addition, there is an effort to develop new anatomical methods to improve our understanding of brain circuits, connectivity, and function.
Much of the work is highly collaborative and interdisciplinary. Many neuroscientists apply physics, math, and engineering principles to the study of cognition, including research funded by the Swartz Foundation. The Stanley Center for Cognitive Genomics integrates genetics and neuroscience to form a dual-strategy aimed at improving the diagnosis and treatment of schizophrenia, bipolar disorder, depression and other cognitive disorders.
Dinu Florin
Dinu Florin Albeanu - Associate Professor

Works to understand how the brain builds adaptive internal models of the world and how underlying neuronal circuits decode information from the environment and are shaped by attention, context and sensory experience. Specific focus on connections within the olfactory system.
Anne Churchland - Associate Professor

Investigates the neural circuits that support decision-making in humans and animals. In particular, the lab studies circuits that allow organisms to integrate multiple sources of information for decisions. These include sights, sounds, and even memories of previous decisions.
Tatiana Engel - Assistant Professor

Investigates how perception and cognition arise from changes in neural activity. Her lab develops and applies computational methods to discover dynamic patterns in large-scale neural activity recordings and creates mathematical models to explain how these activity changes emerge from signaling between neurons, ultimately driving behavior.
Hiro Furukawa - Professor

Performs structural and functional studies to determine the molecular mechanisms involved in synaptic transmission and plasticity. Focuses on genetic mutations in N-methyl-D-aspartate receptors (NMDARs) as well as other synaptic receptors, channels, transporters, and enzymes.
Z. Josh
Z. Josh Huang - Professor

Studies the development and organization of neural circuits in the mouse cerebral cortex. His team uses an integrated approach to identify neuronal cell types and discover how they interact to process information and guide behavior, focusing on the motor cortex that controls forelimb movement. His studies of inhibitory interneurons, such as chandelier cells, have implications for understanding schizophrenia and autism.
Adam Kepecs - Professor

Studies cognition and decision-making in rodents, with the goal of uncovering the neural basis of complex behavior that will inform the development of next generation therapies for schizophrenia, major depression and Alzheimer's disease. Also using computational approaches to develop data-driven, quantitative classification methods for psychiatric disorders.
Alexei Koulakov - Professor

Applies methods from theoretical physics, machine learning, and mathematics to study how neurons process information, how brain networks assemble during development, and how brain architecture evolved to facilitate its function. His work has generated robust theoretical models of visual and olfactory neural circuits.
Bo Li - Professor

Seeks to understand the link between neural circuits and behavior. By probing and manipulating specific circuits in the rodent brain, the lab aims to identify synaptic and circuit mechanisms underlying associative learning and reinforcement learning, as well as cognitive dysfunctions related to mental disorders, including depression, anxiety disorders, and autism.
Gholson Lyon - Assistant Professor

Studies the pathophysiology of severe neurodevelopmental disorders. Uses next generation sequencing, induced pluripotent stem cells and mouse models to perform detailed functional studies of rare genetic mutations in families with increased prevalence of facial dysmorphology, intellectual disability, and/or autism.
Partha Mitra - Professor

Combines theoretical, computational and experimental approaches to study complex biological systems, focusing on neurobiological questions; also a lead organizer of the Brain Architecture Project, a collaborative effort to produce a comprehensive draft of the connectivity patterns of the human brain.
Pavel Osten - Associate Professor

Studies how genetic mutations affect neural circuits in cognitive disorders. Developed advanced imaging methods to draw the first whole-brain activation map in mice and is now applying the technology to study changes in brain activity in mouse models of autism and schizophrenia.  
Stephen Shea - Associate Professor

Studies the neural circuits underlying innate behaviors using genetics, electrophysiology and behavioral analysis. Examining how disruptions in these circuits can lead to inappropriate use of social information, as in Autism Spectrum Disorders.
Jessica Tollkuhn - Assistant Professor

Seeks to understand how transient events during development exert lasting effects on the brain and behavior. The lab studies how steroid hormones establish and regulate sexually dimorphic neural circuits. The goal is to provide a mechanistic link between the epigenetic events mediated by hormone receptors, and the consequent sex differences in social circuitry and behavior.
Linda Van Aelst - Professor

Elucidating pathogenic mechanisms underlying neurodevelopmental and neurological disorders that impact cognition and behavior. Using a multidisciplinary approach to investigate the molecular, cellular, and circuit basis of these disorders, with a particular focus on the characterization of Rho-linked genes associated with human diseases.
Anthony Zador - Professor

Studies how neural circuitry in the brain gives rise to complex behaviors, and how disruption of this circuitry in neuropsychiatric disorders like autism and schizophrenia can cause behavioral deficits. The lab is also developing a novel technology that uses "next-gen" sequencing technology to determine the wiring diagram of the brain at the resolution of individual neurons.