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Cold Spring Harbor Scientists Are Part of Consortium
That Sequences Platypus Genome, Unlocking Secrets of Evolution
May 8, 2008
Bruce Stillman, Ph.D., President of CSHL Elected to American Academy of Arts and Sciences
May 2, 2008
Scientists Find Stem Cells For the First Time in the Pituitary
April 28, 2008
The Don Monti Foundation Awards $500,000 Grant to Cold Spring Harbor Laboratory
April 25, 2008
Scientists Clarify a Mechanism of Epigenetic Inheritance
April 22, 2008
Scientists Discover a Mechanism
That Can Send Cells on the Road to Cancer
April 22, 2008
Watson School of Biological Sciences Culminates Commencement Weekend Conferring Degrees on Its Fifth Graduating Class
April 21, 2008
Oliver Sacks, Eric Kandel and Paul G. Allen to Receive Honorary
Degrees at Watson School of Biological Sciences’ Commencement
April 11, 2008
Scientists Find a Fingerprint of Evolution
Across the Human Genome
April 8, 2008
iPlant Kickoff Conference at Cold Spring Harbor Laboratory Begins Tackling Plant Biology's Grand Challenges
April 4, 2008
Cold Spring Harbor Laboratory Scientists
Devise Potential Approach To Treat Spinal Muscular Atrophy
April 4, 2008
Cold Spring Harbor Laboratory Scientists
Identify A Mechanism That Helps Fruit Flies Lock-In Memories
March 28, 2008
CSHL Scientists Part of Multi-Institution Team That Discovers Role of Rare Gene Mutations in Schizophrenia
March 28, 2008
Cold Spring Harbor Laboratory Opens Doors to Public
February 29, 2008
CSHL Ranks In Top One Percent Of Institutions
Impacting Future Biomedical Diagnoses and Treatments
February 25, 2008
Scientists at CSHL Discover New Details of a Gene-Regulatory Network Governing Metabolism
February 22, 2008
Scientists at Cold Spring Harbor Laboratory Hone Method To Selectively Target Cancer Genes and Cells
February 21, 2008
CSHL To Play Central Role Addressing Key Questions In Plant Biology
January 30, 2008
Scientists At Cold Spring Harbor Laboratory Make Progress
In Determining How The Brain Selectively Interprets Sound
January 29, 2008
Christina Renna Foundation Presents Inaugural Grant To CSHL for Pediatric Cancer Research
January 29, 2008
CSHL Researchers Race Against Time To Save Tasmanian Devils
January 28, 2008
New Leadership at CSHL’s Swartz Center for Computational Neuroscience
January 28, 2008
New York State Supports CSHL Expansion and Stem-cell Research
January 11, 2008
Scientists at Cold Spring Harbor Laboratory Identify Cells That Promote Formation of Lethal Lung Metastases
January 10, 2008
Cold Spring Harbor Laboratory’s Innovative Lung Cancer Research Program Awarded $100,000 Grant
January 9, 2008
Joni Gladowsky Breast Cancer Foundation Funds Innovative Breast Cancer Research at Cold Spring Harbor Laboratory
January 8, 2008
Unexpected Sensitivity of Brain Circuits Is Revealed by Neuroscientists at Cold Spring Harbor Laboratory
January 8, 2008
Saturday DNA! Program Unravels Genetic Mysteries for Children and Adults
January 3, 2008
Cold Spring Harbor Laboratory Scientists Report Ability to
Identify and Repress Breast Cancer Stem Cells in Mouse Tissue
December 17, 2007
Brain Stem Cells Sensitive to Space Radiation
December 11, 2007
CSHL Scientist Recognized for Accelerating Cancer Gene Research
December 6, 2007
$3.1 Million Raised at Cold Spring Harbor Laboratory’s 2007 Double Helix Medals Dinner
November 21, 2007
NIH Awards Grant to Cancer Education Program At Cold Spring Harbor Laboratory’s Dolan DNA Learning Center
November 14, 2007
Team of Scientists Develops Non-Invasive Method to Track Nerve-Cell Development in Live Human Brain
November 8, 2007
Cold Spring Harbor Scientists Devise Novel, Low-Cost Method of Sifting Genome’s High-Value Regions
November 6, 2007
Dr. James D. Watson Retires as Chancellor of Cold Spring Harbor Laboratory
October 25, 2007
Statement by Cold Spring Harbor Laboratory Board of Trustees and President Bruce Stillman, Ph.D.
Regarding Dr. Watson’s Comments in The Sunday Times on October 14, 2007
October 18, 2007
Statement by Cold Spring Harbor Laboratory Board of Trustees and President Bruce Stillman, Ph.D.
Regarding Dr. Watson’s Comments in The Sunday Times on October 14, 2007
October 17, 2007
Nobel Laureates and Laurel Hollow Mayor participate in Groundbreaking Ceremony for Expanded Library and Archives
October 16, 2007
Gregory Hannon Wins 2007 Paul Marks Prize for Contributions to Understanding and Treating Cancer
October 12, 2007
Researchers Discover Three New Genes That Cause Lung Cancer
October 08, 2007
CSHL Awarded Highest Independent Rating for Sound Fiscal Management
August 8, 2007
CSHL, DuPont Join Forces to
Boost Crop Yields, Meet Global Demand
July 31, 2007
New Model for Autism Suggests Women Carry the Disorder and Explains Age as a Risk Factor
July 23, 2007
CSHL, CompuCyte Corporation Establish Regional Quantitative Imaging Cytometry Center
June 29, 2007
Watson Genotype Viewer Now On Line
June 28, 2007
Cold Spring Harbor Laboratory Announces New Dean
June 25, 2007
Psychiatric Genomics Center Established
at CSHL with $25 million gift from the Stanley Medical Research Institute
June 22, 2007
CSHL Awarded Pre-College Science Education Grant
by Howard Hughes Medical Institute
June 21, 2007
CSHL Scientists Successfully Target Tumor Microenvironment to Stop Cancer Growth
June 15, 2007
Study Shows Big Power of Small RNAs, Not Just Proteins,
in Halting Cancer
June 6, 2007
James Watson receives personal genome in ceremony at Baylor College of Medicine
May 31, 2007
Cold Spring Harbor Laboratory Links Activity in Brain Synapses and Developmental Abnormalities with Schizophrenia Gene
May 24, 2007
CSHL Selected for modENCODE Data Coordination Center
May 15, 2007
CSHL Announces An Additional Cultural Series Lecture on Autism
May 15, 2007
Cold Spring Harbor Laboratory President Wins Curtin Medal
May 3, 2007
DNA Learning Center Launches DNA Today Podcast Series
May 2, 2007
April 25 is National DNA Day
April 20, 2007
2007 Cold Spring Harbor Laboratory Science Walking Tours
March 21, 2007
CSHL Scientists Confirm Genetic Distinction Between Heritable and Sporadic Cases of Autism
March 15, 2007
CSHL Shows Correcting RNA Splicing May Help Treat Spinal Muscular Atrophy
March 12, 2007
Cold Spring Harbor Laboratory Announces 2007 Cultural Series
March 6, 2007
CSHL Research Ties Harmless Viruses to Cancer
February 22, 2007
CSHL Researchers Show RNA Splicing Factor May Be New Target for Cancer Therapy
February 18, 2007
CSHL Scientists Discover New Gene That Prevents Multiple Types of Cancer
February 8, 2007
CSHL Collaboration Suggests New Strategy to Treat Resistant Cancers
January 24, 2007
James D. Watson Sets the Record Straight on January 2007 Esquire Interview
January 19, 2007
Science Soirees: Conversations on Science and Society
Launched to Inspire Non-Scientists
January 19, 2007
CSHL molecular biologist honored by National Academy of Sciences
January 17, 2007
Genomic ‘firestorms’ underlie aggressive breast cancer progression
December 1, 2006
Waltz of the Polypeptides Joins Cold Spring Harbor Laboratory's Art of Science Collection
November 21, 2006
CSHL Raises $2.5 Million at Inaugural Double Helix Medals Event
November 9, 2006
CSHL Receives Nanomedicine Center Grant
October 23, 2006
Starr Foundation Launches Multi-Institutional Cancer Consortium
September 21, 2006
Former CSHL Scientist Wins Lasker Award
September 17, 2006
Masthead Cove Yacht Club Raises Sails (and Funds) for Ovarian Cancer Research
August 27, 2006
How
the Brain Combines Economic and Spatial Information
August
17,
2006
Lumera
Debuts ProteomicProcessor
June
30 , 2006
New Clues
To Liver Cancer
June
30 , 2006
OSI
Pharmaceuticals Foundation Awards Grant to DNALC
June
23 , 2006
Two
Post-Docs Receive NARSAD Young Investigator Awards
June
23 , 2006
Women’s
Partnership for Science Luncheon Has Fifth Successful Year
June
23 , 2006
Cold
Spring Harbor Laboratory Press Launches CSH Protocols
June
19 , 2006
William
Tansey Honored by the LLS
June
7 ,
2006
Prozac's Target Revealed
May 15 , 2006
Scott
Livingston Joins DNALC Board
April
18, 2006
WSBS Commencement Scheduled for April 30
April 12, 2006
Genentech
Donates $2.5 Million to CSHL
April
5,
2006
Spring
Saturday DNA!
March
31, 2006
Stopping
Mad Cow Disease with RNA Interference
March
20, 2006
Faster,
Stronger…Genetically Modified?
March
13, 2006
2006
Cultural Series
March
7,
2006
CSHL
Earns Unprecedented Ranking
January
12,
2006
Why
the Brain Has "Gray Matter"
December
30,
2005
Scott
Lowe Wins Paul Marks Prize
November
17, 2005
Bird
Flu and the Global Threat of Emerging Respiratory Diseases
November
16, 2005
Dr.
David Mu Researches Lung Cancer In Women
November
11, 2005
CSHL
Named a 2006 Beneficiary of the Long Island 2 Day Walk
November
11, 2005
NIH
and Advocacy Groups Fund Autism Research
November
8, 2005
Common
Viruses May Cause Cancer
November
7, 2005
DNALC
to Produce Content for BiosciEdNet
November
7,
2005
Catalog
of Human Genetic Variation Speeds Disease Research
October
27, 2005
New
Gene Regulation Mechanism Discovered
October
20, 2005
"Gramene"
Database Facilitates Agricultural Research
October
13, 2005
Smokey
Robinson to Perform at Benefit for the Brain
September
29, 2005
Dr.
Holly Cline Receives 2005 NIH Director's Pioneer Award
September
29, 2005
CSHL
Receives NSF Funding for Semantic Web Development
September
29, 2005
Six Local
Students Partner with CSHL
September
13, 2005
Gene Loss
Accelerates Aging
August
16, 2005
Rice Genome Sequence
Completed
August
11,
2005
Harrison's Heart
Foundation's September Gala toBenefit CSHL
August
1, 2005
Structural Basis
of Malaria Infection
July
28, 2005
Genetic Origins
of Corn on the Cob
July
24, 2005
Libraries and
Archives Hosts "Memories Under the Moonlight"
July
21, 2005
Simons Donates
$11 million Towards Landmark Autism Initiative
July
20,
2005
Nassau County Senate
Delegation Breaks Ground for Biotechnology
July
14,
2005
Small RNA's Play
Big Role In Cancer
June
9, 2005
Father Tom Funds
Parkinson's Research at CSHL
May
9, 2005
Two CSHL Researchers
Win NARSAD Awards
May
17, 2005
Good Vibes Resound
at JAZZ at the LAB
May
4, 2005
Legacy of Barbara
McClintock Immortalized by the USPS
May
2, 2005
2005
AACR Award for Outstanding Achievement in Cancer Research
April
27, 2005
Zachary
Lippman, 2005 Watson School Graduate, Lives a "Larger-Than" Life
April
17, 2005
LI 2 Day Walk
April Training Schedule
April
5, 2005
Second WSBS Class Graduates
on April 17, 2005
April
4, 2005
CSHL and Farmingdale State
University of New York Juxtapose Music, Art and Science
April
4, 2005
Harold M. Weintraub Award Winner
March
22, 2005
CSH Main Street Association
Paints the Town Pink
March
22, 2005
HHMI
Taps Two LI Researchers
March
21, 2005
Researchers Uncover Scaffolds
in the Brain's Wiring Diagram
March
1, 2005
Second Annual “Long
Island 2 Day Walk
to Fight Breast Cancer”
Scheduled for June 4-5
March
1, 2005
New Clues to the Mechanism of Short-Term Memory
February
18, 2005
Sleep First Hinders,
Then Helps Vocal Learning
February
17, 2005
1
in 9 and Michael's Haven Present Grants to CSHL
February
3,
2005
DNALC Grant Will Connect
Research, Education and Technology
February
1,
2005
The World is a Song
January
24th,
2005
New York Academy of Sciences
Launches "Science Alliance"
January
7th,
2005
New Officers Elected to Board
December
8th,
2004
Father Tom and Dr. Watson Announce
Partnership
October
25th,
2004
Benefit for the Brain, October
30
October
1st,
2004
"Immediately Open Access" Option for Genome Research Papers
September
27th, 2004
NARSAD awards
$200,000 in Research Grants
September
23rd, 2004
$5 Million NSF Grant Supports
Plant Research
September 20th,
2004
CSHL Scientist Named to "Brilliant Ten" List
September
20th,
2004
Alzheimer’s Symposium Meets
Demand on Long Island
August 23rd,
2004
LIABC Serves Up Another
Successful Tennis Tournament
August 20th,
2004
SMA Foundation Brings Experienced
Researcher to CSHL
July 30th,
2004
RNAi Breakthrough
July 28th,
2004
Surprising Variation in the
Human Genome
July 22nd,
2004
Third Time's a Charm: Women's
Partnership for Science Luncheon Successful Again
July 20th,
2004
CSHL Press Textbooks Required
for Purdue University's New H.O.T. Biology Lab Courses
July 9th,
2004
New Appointments at WSBS Mark Second Generation of Leadership
July 1st,
2004
Founding Dean of Watson School
of Biological Sciences Resigns To Pursue Research
July 1st,
2004
Congresswoman McCarthy Observes
Appropriations In Use At Cold Spring Harbor Laboratory
June 30th,
2004
US Rice Genome Consortia Awarded by USDA Secretary
June 25th,
2004
NARSAD Funds Two Cold Spring Harbor Laboratory Researchers
June 23rd,
2004
Stillman Receives Alfred
P. Sloan, Jr. Prize
June 10th,
2004
International Consortium Launches
New Web-Based Tool: Reactome
June 2nd,
2004
Sabin Vaccine Institute Honors
DNA Scientist James Watson
May 14th,
2004
First Watson School Students
to Graduate on April 25, 2004
April 15th,
2004
Human RNA Interference
Library Spurs Biotech and Pharma Research
March 24th,
2004
Combination Therapy
for Cancer Shows Promise
March 17th,
2004
Visualizing
the Central Dogma
March
5th,
2004
2004 Cultural
Series Celebrating A Century of Genetic Research
March
1st,
2004
DNA
Interactive Wins Academy Award
March
1st,
2004
Metlife Foundation Recognizes
Alzheimer's Disease Research
February
23rd,
2004
Swartz Foundation Establishes Computational Neuroscience Center
February
12th,
2004
2004 Benjamin Franklin Award Laureate
February
12th,
2004
AACR-National Foundation For
Cancer Research
February
11th,
2004
Institute of the Year
January 14th,
2004
International HapMap Project
December 17th
,
2003
Corn Genome Deciphered
December 28th
,
2003
Bruce Stillman Named President
December
1st , 2003
Grant Increase Understanding of
Fragile X
November
26th, 2003
NSF Plant Genome Grants Fund Three Projects
November
26th, 2003
Cold Spring Harbor, A 2004 Calendar On Sale
November
19th, 2003
Course to the Prize
October
23th, 2003
The Speed of Smell
October
20th, 2003
Collaborative Grant
Propels Leukemia Research
October
5th, 2003
Revealing the Genetic
Basis of Cancer
September 16th,
2003
Fashion As Unique As Your DNA
September
5th, 2003
Nitric Oxide Regulates
Cell Division in the Adult Brain
July 28th, 2003
Unique Collaboration Offers A Rare Opportunity To Spend A Day With DNA
July 27th, 2003
New York Women Become Mentors To Local Scientists
July 27th, 2003
Silent DNA Architecture Blocks Cancer Cell Growth
June 13th, 2003
"Origins" Project Features CSHL
May 28th, 2003
Howard Hughes Medical Institute Renews Support for CSHL Postgraduate Courses
May 15th, 2003
New York Public Library Exhibit Now Open
May 11th, 2003
Cold Spring Harbor Laboratory's 2003 Cultural Series Honors DNA Discovery
May 8th, 2003
Researchers Discover New Breast Cancer Gene
March 26th, 2003
Dolan DNA Learning Center Launches DNA Interactive Website
February 28th, 2003
"Pavlov's Flies" Reveal New Memory Genes
February 17th, 2003
RNAi in Stem Cells
February 2nd, 2003
CSHL Ranked #1 in Survey of Research Impact
February 1st, 2003
Researchers Achieve Germline Transmission of RNAi "Gene Knockdown" in Mice
January 19th, 2003
Designer Molecules Correct RNA Splicing Defects
January 12th, 2003
"Breakthrough of the Year" Recognition Goes to CSHL Scientists
December 19th, 2002
Researchers Reveal New Secrets of the Brain
December 18th, 2002
Mouse Genome Published: Medical Research to Benefit
December 4th, 2002
Researchers Discover New Breast Cancer Gene
October 6th, 2002
New Clues to Brain Development
October 2nd, 2002
"The Genes We Share" Exhibit Opens to the Public
September 16th, 2002
All in the Family: Alumni Association Founded
September 16th, 2002
Dr. Hollis Cline Appointed Associate Director for Research
August 27th, 2002
Dr. Winship Herr steps down as Assistant Director to devote his efforts to
the Watson School of Biological Sciences
August 27th, 2002
Cold Spring Harbor Laboratory Teams with Singapore's Ministry of
Education to Improve Life Sciences Education in Singapore
August 27th, 2002
Cancer Genetics & Tumor Suppressor Genes Meeting
August 14th, 2002
Scientists and Cold Spring Harbor Laboratory Press Fight HIV/AIDS in Africa
July 9th, 2002
Scientific American 2002 Awards
June 14th, 2002
Scientific American 2002 Science and Technology Web Award
Bioterrorism
June 4th, 2002
Bioterrorism Panel Discussion at Cold Spring Harbor Laboratory
67th Symposium
May 28th, 2002
2002 CSHL Symposium Focuses on Cardiovascular System
Retrovirologists Gather at CSHL
May 20th, 2002
Nobel Laureate to Deliver Keynote Address at Cold Spring Harbor Laboratory:
May 13th, 2002
"Cell Cycle" Meeting Attracts Two of Three 2001 Nobel Laureates in Physiology or Medicine
Top Genome Researchers Gather at Cold Spring Harbor
May 7th, 2002
Some 500 of the top genome scientists from around the world meet at Cold Spring Harbor Laboratory this week for the annual Genome Sequencing & Biology meeting.
Scientists Report Efficient "Gene Silencing" Strategy
April 14th, 2002
Treatments for cancer, AIDS and a host of other diseases may lie in scraps of hairpin-shaped RNA.
New Clue to Understanding Fundamental Brain Mechanism
March 26th, 2002
Researchers have found that they can enhance memory in fruit flies by boosting the level of a protein called PKM.
New Technique Speeds Gene Research in Mammalian Cells
January 29th, 2002
CSHL scientist Gregory Hannon and his colleagues report a new technique for carrying out genetic analysis directly in mammalian cells. The technique has the potential to greatly simplify gene manipulation and gene discovery for many biomedical applications.
Scientists Reveal Key Trigger of Fat Cell Development
January 1st, 2002
Researchers led by scientists at Harvard Medical School and Pfizer Inc. have independently discovered a gene that controls fat cell development. Their studies, published in the January 1 issue of Genes & Development, are significant because obesity affects approximately 1 in 4 adults and 1 in 5 children in the United States alone.
New Book Distills Essence of Gene Regulation (and more)
December 18th, 2001
In a new book, Genes & Signals (Cold Spring Harbor Laboratory Press, 2002), Mark Ptashne of Memorial Sloan-Kettering Cancer Center and Alexander Gann of Cold Spring Harbor Laboratory provide a lucid description of a fundamental gene regulation mechanism that we now know is found throughout biology. Moreover, Ptashne and Gann describe how a similar mechanism underlies not only gene regulation, but also other molecular processes within cells, including signal transduction, protein degradation and pre-mRNA splicing.
Neuroscientist Receives Grand Prize at Nobel Ceremony
December 5, 2001
Song-Hai Shi, a 2000 graduate of the joint Genetics Program at Cold Spring Harbor Laboratory and SUNY Stony Brook, is the winner of the 2001 Amersham Biosciences & Science Prize for work he carried out in the laboratory of CSHL neuroscientist Roberto Malinow. Shi received this prestigious award for young researchers at the Centennial Nobel Prize ceremony in Stockholm, Sweden, on December 5th. He was the Grand Prize Winner among a group of six finalists from Sweden, Germany, New York (2), Japan and Israel.
Finding Genes in the Human Genome:
New Computer Program Detects Overlooked Gene Segments
November 28, 2001
In order to study genes for a wide variety of research, diagnostic, or therapeutic purposes, scientists use computer programs that analyze DNA sequences. These programs indicate where pieces of genes are located within what is frequently a vast and complex genetic landscape. Although conventional programs detect many parts of genes with ease, they fail when it comes to detecting two important elements-the very first pieces of genes, and the nearby "on" switches of genes called promoters. Researchers in the bioinformatics group at Cold Spring Harbor Laboratory have now developed a computer program that is especially good at finding these first segments and "on" switches of genes. The program is tailored toward detecting these features in the human genome sequence, but it will also be useful for annotating other mammalian genomes.
Scientists Reveal Role for Nitric Oxide During Brain Development
November 14, 2001
Scientists at Cold Spring Harbor Laboratory have found that experimentally altering nitric
oxide levels in the developing brain of tadpoles significantly affects brain size and the
number of brain cells. The study is significant because it is the first definitive demonstration
of the essential role of nitric oxide during vertebrate brain development.
"Histone Code" Joins Genetic Code as Critical Determinant of Chromosomal Inheritance:
Study RevealsKey Properties of Silent versus Active DNA
August 9, 2001
Until recently, proteins called "histones" have been the Rodney Dangerfields ("I don't get no respect!") of the biochemical world. Histones bind to DNA and wrap the genetic material into "beads on a string" in which DNA (the string) is wrapped around small blobs of histones (the beads) at regular intervals. In the past, many researchers believed that histones played a passive role in chromosome architecture and little role in specifically switching genes on and off. Now, scientists who remained true to histone research are basking in the glow of renewed respect for the dynamic role that these proteins are being found to play in the inheritance of specialized chromosome structures and the control of gene activity.
Rescuing Cells from the Brink of Death (or Pushing Them Over It):
Implications for Neurodegenerative Disease, Stroke Recovery, and Cancer
July 11, 2001
Multicellular life is a balance between cell survival and cell death. The genetically programmed death of cells is a normal part of embryonic development and occurs throughout the lifetime of organisms to rid abnormal (e.g. pre-cancerous) and surplus cells from the body. Research at Cold Spring Harbor Laboratory now reveals that under special circumstances, cells programmed to die during nervous system development can be brought back from the brink of death. This finding has important implications for the treatment of neurodegenerative disease, stroke, and cancer.
Scientists Switch Memory Recall On and Off in Fruit Flies
May 23, 2001
Scientists at Cold Spring Harbor Laboratory have used a genetic strategy in fruit flies to switch electrical activity in the insect brain on and off at will. In doing so, they have made the surprising discovery that switching off electrical activity in the brain blocks memory recall, but not initial formation of memory.
Cold Spring Harbor Laboratory Scientist Elected Fellow of Royal Society
May 14, 2001
On May 14, the Royal Society of London announced the election of new Fellows to its ranks in recognition of their distinguished achievements in scientific research. Nicholas K. Tonks of Cold Spring Harbor Laboratory was among these newly elected Fellows of the Royal Society. Dr. Tonks is recognized internationally for his studies of a diverse family of enzymes called protein tyrosine phosphatases. In 1997, Tonks and his colleagues at Cold Spring Harbor Laboratory and Columbia University were among the first scientists to demonstrate that abnormalities in the function of a protein tyrosine phosphatase can lead to cancer.
RNA Splicing Study Aids Understanding of Breast Cancer,
Cystic Fibrosis and Other Diseases
April 16, 2001
Mutations in the breast cancer susceptibility gene BRCA1 are responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. Certain "nonsense" mutations in the BRCA1 gene are known to cause RNA splicing defects ("exon skipping"), which lead to the production of abnormal BRCA1 proteins that are missing a particular segment. Until now, scientists have lacked a clear understanding of this phenomenon, which they term nonsense-associated altered splicing, or NAS.
New Clue for Diagnosis and Treatment of Malignant Melanoma
January 10, 2001
Malignant melanoma is an aggressive, deadly cancer that does not respond to conventional chemotherapy. Other aggressive, chemoresistant cancers - and approximately half of all cancers - are characterized by mutations in the p53 tumor suppressor gene. Malignant melanomas, however, do not typically display mutations in the p53 gene.
To explore the origins of malignant melanoma, and to identify potential targets and strategies for therapy, Scott Lowe and his colleagues at Cold Spring Harbor Laboratory have examined the status of other genes known to function downstream of p53 in a pathway leading to "apoptosis" or "programmed cell death." In a study published today in Nature, Lowe and his colleagues report that malignant melanomas often lose a key trigger of programmed cell death - a protein called Apaf-1 (apoptosis activation factor-1).
Scientists Report First Complete Genome Sequence of a Plant
December 13, 2000
An international effort to sequence the entire genome of the plant
species Arabidopsis thaliana is now complete. This first-ever complete
genome sequence from a plant has many implications for biology,
medicine, agriculture, and the environment because it will enable
detailed studies of the entire genetic structure of plants to be carried
out. Such studies will yield a great deal of new information about the
gene products that are involved in many aspects of plant growth and
development, and how these gene products carry out their functions.
Scientists Reveal Details of Brain Cell Communication:
Implications for Learning & Memory
November 29, 2000
Forget gigabytes. Even the most powerful computers available today are mere playthings compared to the complexity, efficiency, and information
processing capacity of the human brain. Underlying the brain's far superior design are the billion-million or so connections between brain cells-called
synapses-that form vast neural networks in which brain cells, or neurons, are each connected to thousands of other neurons. These networks-and their
ability to be shaped by experience-enable us to receive, process, store, and retrieve all manner of information about our world. Unfortunately, the
extremely tiny size of synapses and the limitations of conventional experimental techniques have hampered detailed studies of these essential structures.
(One trillion synaptic compartments, or "dendritic spines," could fit into a thimble). Now, scientists at Cold Spring Harbor Laboratory have overcome these
technical obstacles to gain an extremely close look at the properties of dendritic spines and synapses that govern brain function.
The silence of the clones: new link between
DNA replication and 'silent' chromosome architecture
November 8, 2000
As genetically identical cells (such as those in an embryo) multiply, different sets of genes are switched on, and
others off, giving rise to cells and tissues with distinctive properties (e.g. liver
versus muscle). Such differential gene expression is determined in part by the large-scale architecture or chromatin structure of DNA. "Silent" regions of DNA are tightly
packaged into forms of chromatin that are less accessible to transcriptional activators, the proteins that switch genes on. Now, Bruce Stillman and his colleagues at Cold Spring Harbor Laboratory have demonstrated how a set of proteins work in concert to duplicate
both the basic sequence of DNA as well as silenced states of chromatin structure. The findings, published tomorrow in Nature, provide the first detailed
mechanism to explain how both DNA sequences and their associated states of gene
expression are coordinately passed on to future generations of cells.
Scientists Issue Telomerase Caution
June 14, 2000
The enzyme telomerase has received a great deal of attention since 1998
when researchers showed that expressing this enzyme in human tissue
culture cells significantly extended the life-span of the cells.
Telomerase expression was immediately recognized as a useful strategy
for growing the large number of cells required for cell-based
therapeutic procedures. Now, however, scientists report that using
telomerase to extend the life-span of human tissue culture cells is
associated with activation of the c-myc oncogene and thus may present
some level of cancer risk if the cells are intended for therapeutic use
in humans.
Director of Cold Spring Harbor Laboratory
Elected to National Academy of Sciences
May 4, 2000
Today, the National Academy of Sciences elected 60 new members and 15 foreign associates to its ranks in recognition of their distinguished achievements in scientific research. Bruce Stillman, director of Cold Spring Harbor Laboratory, was among these newly elected members of the Academy. This year's election, at the 137th annual meeting of the Academy in Washington, D.C., brings its number of active members to 1,843 and Cold Spring Harbor Laboratory's share of this membership to three: In addition to Dr. Stillman, James Watson (elected in 1962), and Michael Wigler (elected in 1989) are members of the National Academy of Sciences currently working at Cold Spring Harbor Laboratory (CSHL).
Movies of Intact Brain Reveal How
Sensory Experience Shapes Neural Connections
April 20, 2000
Rats, mice, and other rodent denizens of the shadows use their whiskers to explore their surroundings by feel. Now, researchers at Cold Spring Harbor Laboratory have captured time-lapse images that show how neurons in a young rat's brain change as the animal experiences its world through its whiskers for the first time. The study is reported in today's issue of Nature.
New Link Uncovered in Nerve Cell Mechanism
Thought to Power Learning and Memory
March 23, 2000
Researchers at Cold Spring Harbor Laboratory have uncovered a significant new link in the molecular chain of events thought to underlie learning and memory. By using a novel electrophysiological method for measuring synaptic activity, Roberto Malinow and his colleagues have demonstrated that strengthening of nerve cell connections in the brain—believed to occur during learning and memory consolidation—can be largely explained by the movement of proteins called AMPA receptors into synapses. The study is reported in today's issue of Science.
Maternal Genes Rule During Early Development:
Possible Mechanism to Filter Deleterious Mutations
March 3, 2000
For many years, scientists studying gene expression in plants assumed
that genes inherited from both male and female parental sources
contribute equally to development after fertilization. A new study by
scientists working at Cold Spring Harbor Laboratory challenges this
view, and instead indicates that the first few days of embryonic
development are controlled largely if not exclusively by the maternal
genome.
Web Site Opens Window on Dark Episode in American Science
February 11, 2000
Today, Cold Spring Harbor Laboratory’s DNA Learning Center opened its
Image Archive on the American Eugenics Movement web site to the public
(http://vector.cshl.org/eugenics/). The Archive contains over 1,200 photographs and documents chronicling the early 20th century American
eugenics movement - a movement dedicated to improving the genetic stock
of Americans through "better breeding."
Press Releases Archive
