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Cancer research at Cold Spring Harbor Laboratory represents a comprehensive approach at the molecular level. Scientists here are deeply involved in the process of discovery, studying the structure and function of genes and proteins involved in cancer. Below is a list of research areas, each scientist's name followed by his or her specific focus. CSHL is one of 60 US institutions funded by the Cancer Centers Program of the NCI.
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Greg Hannon - Growth control in mammalian cells; post-transcriptional gene silencing |
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Tatsuya Hirano - Chromosome structure and function; cell cycle control;
Xenopus cell-free system |
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Adrian Krainer - Posttranscriptional regulation of gene expression; pre-mRNA splicing mechanisms; alternative splicing; RNA-protein interactions; cell-free systems |
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Jacek Skowronski - HIV pathogenesis; nef gene; signal transduction; protein sorting;
animal models |
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Arne Stenlund - Viral transformation and tumor formation in papillomavirus; cancer; DNA replication |
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Bruce Stillman - DNA replication; chromatin assembly; biochemistry; yeast genetics; cancer; cell cycle |
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William Tansey - Oncogene regulation; transcription; protein destruction; cell cycle |
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Nicholas Tonks - Posttranslational modification; phosphorylation; phosphatases;
signal transduction; protein structure and function |
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Linda Van Aelst - Signal transduction; Ras and Rac proteins; tumorigenesis; metastasis |
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Michael Wigler - Cancer; genomics; oncogenes; signal transduction; Ras; yeast genetics |
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Scott Lowe - Modulation of apoptosis, chemosensitivity, and senescence by cancer genes |
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Michael Wigler - Cancer; genomics; oncogenes; signal transduction; Ras; yeast genetics |
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Yuri Lazebnik - Apoptosis; caspases; cancer chemotherapy; proteases |
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Scott Lowe - Modulation of apoptosis, chemosensitivity, and senescence by cancer genes |
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Richard McCombie - Genome structure; DNA sequencing; computational molecular biology; Human Genome Project
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Michael Zhang - Computational genomics; nucleic acid pattern recognition; gene expression |
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Leemor Joshua-Tor - Structural biology; X-ray crystallography; molecular recognition; transcription; proteases |
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David Spector - Cell biology; nuclear structure; microscopy; pre-mRNA splicing |
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Lincoln Stein - Genome informatics; bioinformatics; mapping; software; World Wide Web |
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Michael Zhang - Computational genomics; nucleic acid pattern recognition; gene expression |
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