To explore the genetics of cancer, CSHL scientists are pursuing several novel approaches for detecting mutations in both primary and metastatic tumors and for creating mutations or gene silencing constructs that reveal a role for particular genes in tumorigenesis. These approaches include DNA microarray-based methods for scanning whole genomes to detect genetic lesions in cancer cells, high-throughput DNA sequencing technologies, and RNA interference tools to establish stable, heritable, and reversible gene silencing to drive numerous functional explorations of cancer biology.

Greg Hannon - Growth control in mammalian cells, post-transcriptional gene silencing
Robert Lucito - Genome microarrays, copy number fluctuation, cancer genomics, amplification, deletion; oncogene, tumor suppressor
Richard McCombie - Genome structure; DNA sequencing; computational molecular biology; Human Genome Project
Scott Powers - Cancer gene discovery; cancer diagnostics and therapeutics; cancer biology
Michael Wigler - Genomics; cancer genes; signal transduction; yeast genetics; bioinformatics