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CSHL Research Highlights 1990 to 1999
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1999
Scott Lowe shows that tumors with a normal p53 gene can develop if another
segment of the p53 pathway is inactivated. Schmitt et al., Genes Dev 1999
Oct 15;13(20):2670-7
abstract
press
release
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1998
Nouria Hernandez demonstrates in molecular detail
how a transcriptional activator makes direct contact with the basal
transcriptional apparatus to stimulate transcription. Ford et al., Genes
Dev. 1998 Nov 15;12(22):3528-40.
abstract
Nicholas Tonks and colleagues show that PTEN
is a "dual specificity" phosphatase. Myers et al., Proc Natl
Acad Sci U S A 1998 Nov 10;95(23):13513-8.
abstract
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1997
Michael Wigler and colleagues use RDA to identify
the PTEN tumor suppressor gene. They find that this gene is mutated
in a large percentage of sporadic breast, prostate, and brain tumors.
Li, J et al., Science 275: 1943–1947.
abstract
Tatsuya Hirano discovers condensins and, the
following year, cohesions. These related protein complexes modulate
chromosome structure in preparation for cell division.Hirano
et al., Cell 1997 May 16;89(4):511-21; Losada et al., Genes Dev 1998
Jul 1;12(13):1986-97.
condensin
abstract cohesin
abstract
Scott Lowe and colleagues discover that certain
tumors become resistant to chemotherapy through alterations in apoptotic
pathways. McCurrach et al., Proc Natl Acad Sci U S A 1997 Mar 18;94(6):2345-9.
abstract
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1996
Former and future CSHL faculty Amar Klar and Shiv
Grewal show that in some instances, the stable inheritance of genetic
traits depends not only on DNA, but rather on DNA plus associated proteins.
Grewal & Klar, Cell 1996 Jul 12;86(1):95-101.
abstract
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1995
Yi Zhong discovers a role for the RAS oncogene
in learning and memory. Zhong Y. Nature 1995 Jun 15;375(6532):588-92.
abstract
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1994
Bruce Stillman and his colleagues complete a 10-year
effort to reconstitute DNA replication with purified human proteins.
Waga et al., J Biol Chem 1994 Apr 8;269(14):10923-34.
abstract
David Barford and Nicholas Tonks determine the structure of the enzyme
protein tyrosine phosphatase, which leads to novel strategies for identifying
cellular targets of phosphatase action. Barford et al., Science 1994
Mar 11;263(5152):1397-404.
abstract
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1993
Richard Roberts wins the Nobel
Prize for his 1977 co-discovery of “split genes.” This
prize was shared with Philip Sharp (MIT).
Michael Wigler and Nikolai Lisitsyn develop Representational Difference
Analysis (RDA), a powerful tool for "cloning the differences"
between any two sets of DNA (e.g.normal v. tumor cell DNA). Lisitsyn et
al., Proc Natl Acad Sci U S A 1995 Jan 3;92(1):151-5.
abstract
Richard Roberts and Xiaodong Cheng discover "base flipping"
when they determine the structure of DNA–methyl transferase bound
to DNA. Cheng et al., Cell 1993 Jul 30;74(2):299-307.
abstract
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1992
Grigori Enikolopov and colleagues initiate a series
of discoveries that reveals how nitric oxide instructs cells to stop
dividing, enabling them to differentiate into specialized cell types.
These discoveries lead to a strategy that uses regulators of Nitric
Oxide Synthase to control proliferation of hematopoeitic stem cells
for use in bone marrow transplantation protocols. Peunova & Enikolopov,
Nature 1993 Jul 29;364(6436):450-3.
abstract
Carol Greider, Bruce Futcher, and their colleagues show an association
between telomere shortening and cell aging. Harley at el., Nature 1990
May 31;345(6274):458-60
abstract
Bruce Stillman and his colleagues purify a protein complex (ORC) that
is required to trigger DNA replication in complex organisms including
humans. Fien & Stillman, Mol Cell Biol 1992 Jan;12(1):155-63.
abstract
Robert Martienssen and colleagues devise a "gene-trap"
system for the plant Arabidopsis that employs Barbara McClintock's transposable
elements. |
